CAS: 207291-76-7; Fmoc-Ala-Oh H2O

该化合物是一种受保护的氨酸衍生物,广泛用于peptide合成.该化合物的特点是Fmoc(9-氟烯烃-碳基)组,该组是矿功能的临时保护组,能够在温和的基本条件下有选择地进行保护.它的手势(2S)配置确保了peptide链组装的立体化学完整性.水合形式增强了稳定性和处理能力.该试剂因其纯度高,与固相聚聚物的兼容性和高效组合性而特别受重视.该试剂的强大保护组将侧面反应最小化,从而成为在研究和制药应用中建造复杂的peptide和改良的氨酸序列的可靠选择.

结构式图片

相似化合物

35661-39-3 884880-37-9 1142-20-7

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    专利信息


    专利号:US-9284348-B2
    优先权日:2005-09-20
    标 题:Method for synthesis of peptide using a carrier
    发明人:CHIBA KAZUHIRO; KIM SHOKAKU; KONO YUSUKE
    权利人:JITSUBO CO LTD
    摘要:Disclosed are a carrier for use for separation purpose and a method for separation of a compound which enable a chemical reaction to be performed in a liquid phase, enable a compound of interest to be separated from the liquid phase after the completion of the reaction readily, enable the separated compound to be evaluated by structural analysis or the like while the compound being bound to the carrier, and enable the compound to be separated from the carrier readily. A carrier for separation which has a reaction site capable of reacting with other compound on a benzene ring, and a long-chain group having a specified carbon atom(s) at each of the ortho-position and the para-position of the reaction site through an oxygen atom.

    专利号:US-2010029904-A1
    优先权日:2005-09-20
    标题 :Carrier for Separation, Method for Separation of Compound, and Method for Synthesis of Peptide Using the Carrier

    专利号:US-8633298-B2
    优先权日:2005-09-20
    标 题 :Carrier for separation, method for separation of compound, and method for synthesis of peptide using the carrier

    专利号:US-2014107319-A1
    优先权日:2005-09-20
    标 题 :Carrier for separation, method for separation of compound, and method for synthesis of peptide using the carrier

    专利号:DK-1927584-T3
    优先权日:2005-09-20
    标 题:CARRIER FOR SEPARATION, PROCEDURE FOR SEPARATION OF CONNECTION AND PROCEDURE FOR SYNTHESIS OF PEPTIDE USING THE CARRIER

    专利号:WO-2024101431-A1
    优先权日:2022-11-10
    标 题:Method for synthesizing peptide
    发明人:YANO SHINYA
    权利人:SEKISUI MEDICAL CO LTD
    摘要:The purpose of the present invention is to provide a method for synthesizing a peptide or a long-chain peptide that uses amino acids including an amino acid containing a certain number of hydrophobic amino acids and an amino acid with a functional group on a side chain, the method not including the addition of additional solvents and not reducing the efficiency of Fmoc amino acid condensation reactions or Fmoc removal reactions. Provided is a method for synthesizing a peptide, the peptide containing one or more amino acids with a functional group on a side chain, 50% or more of a hydrophobic amino acid, and 10% or less of an amino acid in which an α amino group is a secondary amino group; or a peptide with 21 or more residues and containing one or more amino acids with a functional group on a side chain. The method comprises introducing a carrier for peptide synthesis expressed by the general formula (1) below into the side chain of the amino acid with the functional group on a side chain.
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    合成参考文献


    参考文献:10.1007/s00726-021-02989-7
    摘要:Schmutzler S, Knappe D, Marx A, Hoffmann R. Solid-phase synthesis of d-fructose-derived Heyns peptides utilizing Nα-Fmoc-Lysin[Nε-(2-deoxy-d-glucos-2-yl),Nε-Boc]-OH as building block. Amino Acids. 2021 May 02;53(6):881–91. doi: 10.1007/s00726-021-02989-7.
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