CAS: 183586-34-7; 6-Methyl-1H-Pyrrolo[3,2-C]Pyridine

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860362-26-1 1082040-98-9 271-34-1

📜2,5-二甲基吡啶置于硫酸,硝酸,铁粉,溶剂黄146,间氯过氧苯甲酸体系中,用 氯仿,N,N-二甲基甲酰胺 用作溶剂,化学反应 11.0H,反应生成6-甲基-1H-吡咯并[3,2-C]吡啶
参考文献:6-(Azaindol-2-yl)Pyridine-3-Sulfonamides As Potent And Selective Inhibitors Targeting Hepatitis C Virus Ns4B
标题:6-(Azaindol-2-yl)Pyridine-3-Sulfonamides As Potent And Selective Inhibitors Targeting Hepatitis C Virus Ns4B
摘要:A Structure-Activity Relationship Investigation Of Various 6-(Azaindol-2-yl)Pyridine-3-Sulfonamides Using The Hcv Replicon Cell Culture Assay Led To The Identification Of A Potent Series Of 7-Azaindoles That Target The Hepatitis C Virus Ns4B. Compound 2Ac,Identified Via Further Optimization Of The Series,Has Excellent Potency Against The Hcv 1B Replicon With An Ec50 Of 2 Nm And A Selectivity Index Of >5000 With Respect To Cellular Gapdh Rna. Compound 2Ac Also Has Excellent Oral Plasma Exposure Levels In Rats,Dogs And Monkeys And Has A Favorable Liver To Plasma Distribution Profile In Rats. (C) 2015 Elsevier Ltd. All Rights Reserved.
Doi:10.1016/j.Bmcl.2014.12.093