专利号:US-2023286918-A1 优先权日:2020-07-02 标 题:Manufacturing process for 3,5-dichloropicolinonitrile for synthesis of vadadustat 发明人:JURKAUSKAS VALDAS; JUNG YOUNG CHUN; KWON TAESOO; KANNAN ARUNACHALAM; GONDI VIJAYA BHASKER 权利人:AKEBIA THERAPEUTICS INC 摘要:Disclosed herein are methods and processes of preparing vadadustat or a pharmaceutically acceptable salts thereof, and intermediates (e.g., a compound of Formula (I), (I-F), (II), or (IV), or a pharmaceutically acceptable salts thereof) useful for the synthesis of vadadustat.
专利号:US-9586984-B2 优先权日:2007-04-09 标题:One-pot synthesis of alpha/beta-O-glycolipids 发明人:GERVAY-HAGUE JACQUELYN; DU WENJUN; KULKARNI SUVARN S; SCHOMBS MATTHEW 权利人:UNIV CALIFORNIA 摘要:The present invention provides a one-pot method of preparing an unprotected α-O-glycolipid. The first step involves contacting a protected α-iodo sugar with a catalyst and a lipid comprising a hydroxy group, under conditions sufficient to prepare a protected α-O-glycolipid. The second step involves deprotecting the protected α-O-glycolipid under conditions sufficient to prepare the unprotected α-O-glycolipid, wherein the contacting and deprotecting steps are performed in a single vessel. The present invention also provides a one-pot method of preparing an unprotected β-O-glycolipid following the steps for the preparation of the unprotected α-O-glycolipid.
专利号:WO-2024013736-A1 优先权日:2022-07-12 标题 :Process for preparing substituted benzamides 发明人:HAMIRANI BHAVINKUMAR; MAHESH GANDHAM; SREEDEVI MANNAM; PILLAI BIJUKUMAR GOPINATHAN 权利人:ADAMA MAKHTESHIM LTD 摘要:The present invention relates to new intermediates for the preparation of pyridylmethylbenzamides via substituted hydroxyiminopyridines or acetamidopyridines, and their innovative preparation processes. The invention discloses, in particular, the total synthesis of fluopicolide fungicide. The preparation of the main substances of the fluopicolide synthesis, specifically, substituted pyridine-2-ylmethanamine or its salt, is disclosed via two different synthesis routes, comprises two novel substances.
专利号:US-2008214386-A1 优先权日:2004-03-01 标题:Catalyst for Cyclic Carbonate Synthesis 发明人:TAKAHASHI TOSHIKAZU; WATAHIKI TSUTOMU; YASUDA HIROYUKI; SAKAKURA TOSHIYASU 权利人:TAKAHASHI TOSHIKAZU; WATAHIKI TSUTOMU; YASUDA HIROYUKI; SAKAKURA TOSHIYASU 摘要:Provided are a solid catalyst which gives a cyclic carbonate at a high yield and a high selectivity, which is stable and which may be readily separated after reaction; and a method of industrially advantageous, inexpensive and safe production of a cyclic carbonate by the use of the catalyst. The catalyst contains an inorganic solid substance having a surface modified with an ionic substance containing a Group 15 element; or contains an ionic substance containing a Group 15 element, and an inorganic solid substance. The modifying group for surface modification of an inorganic solid substance is an ionic substance containing a Group 15 element. The ionic substance containing a Group 15 element is at least one substance selected from organic phosphonium salts, organic ammonium salts, organic arsonium salts and organic antimonium salts.
专利号:WO-2008124729-A1 优先权日:2007-04-09 标题 :One-pot synthesis of alpha/beta-o-glycolipids
专利号:CA-2464107-A1 优先权日:2001-11-26 标 题:Process for the synthesis of amine ethers from secondary amino oxides and uses
参考文献:10.1007/bf00616959 摘要:Apraskin SP, Granskii PV, Denisov GS. Studies on the influence of the electric field on the band of charge transfer of tetraoctylammonium iodide by modulation spectroscopy. Journal of Applied Spectroscopy. 1974 Dec;21(6):1658–60. doi: 10.1007/bf00616959.