CAS: 16357-69-0; 4-Aminopyrimidine-5-Carbonitrile

相似化合物

20737-41-1 16357-83-8 109831-70-1

上下游产品

thi°Carboxamide sodium ethanolate aminomethylene-malononitrile ethanol 4-aminopyrimido(5,5-d)pyrimidine 4-Amino-5-aminomethyl-pyrimidin 4-amino-pyrimidin-5-carboxylic acid 4-aminopyrimidine-5-carbothioamide

📜3-Cyanamino-2-Cyanopropenenitrile Sodium Salt置于5% Pd On Active Carbon 盐酸,氢气,三乙胺体系中,用 甲醇 用作溶剂,25.0 °C,206.84 Kpa 条件下,反应 3.83H,反应生成4-氨基嘧啶-5-甲腈
参考文献:Schmidt,Hans-Werner; Koitz,Gerald; Junek,Hans,Journal Of Heterocyclic Chemistry,1987,Vol. 24,P. 1305-1307
标题:Schmidt,Hans-Werner; Koitz,Gerald; Junek,Hans,Journal Of Heterocyclic Chemistry,1987,Vol. 24,P. 1305-1307

专利信息

专利号:WO-2011116933-A1
优先权日:2010-03-24
标 题 :Process for the preparation of 2-substituted 4-amino-5-cyanopyrimidines
发明人：DICK VIKTOR; HANSELMANN PAUL; KRAMER RAINER; LADNAK VIKTOR
权利人:LONZA AG; DICK VIKTOR; HANSELMANN PAUL; KRAMER RAINER; LADNAK VIKTOR
摘要:A compound of the formula (I), wherein R 1 is C 1-4 alkyl or phenyl, is prepared by reacting a dicyanomethanide of the formula: M r n + [CH(CN) 2 ] rÌ… n (II), wherein M is an alkali or alkaline earth metal and r is 1 or 2, with carbon monoxide to obtain a dicyanoethenolate of the formula: M r n + [(NC) 2 C=CH–O] rÌ… (III), which is acylated to obtain an acyloxymethylenemalononitrile of the formula: (NC) 2 C=CH–OCOR 2 (IV), wherein R 2 is C 1-4 alkyl, which in turn is reacted with an amidine of the formula (V) to obtain the 4-amino-5-cyanopyrimidine of the formula (I). The compound of formula (I), wherein R is methyl, is an intermediate in a synthesis of thiamin (vitamin B 1 ).