CAS: 1628530-38-0; N-(4-((6,7-Dimethoxyquinolin-4-yl)Oxy)Phenyl)-N-(4-Fluoro-2-Hydroxyphenyl)Cyclopropane-1,1-Dicarboxamide

英文名称N-(4-((6,7-Dimethoxyquinolin-4-yl)Oxy)Phenyl)-N-(4-Fluoro-2-Hydroxyphenyl)Cyclopropane-1,1-Dicarboxamide
中文名称卡博替尼杂质65
IUPAC名称N-(4-((6,7-dimethoxyquinolin-4-yl)oxy)phenyl)-N-(4-fluoro-2-hydroxyphenyl)cyclopropane-1,1-dicarboxamide
其它别名N-[4-[(6,7-Dimethoxy-4-Quinolinyl)Oxy]Phenyl]-N'-(4-Fluoro-2-Hydroxyphenyl)-1,1-Cyclopropanedicarboxamide; Cabozantinib Impurity Dx2; Cabozantinib Impurity 65; 1,1-Cyclopropanedicarboxamide, N-[4-[(6,7-Dimethoxy-4-Quinolinyl)Oxy]Phenyl]-N'-(4-Fluoro-2-Hydroxyphenyl)-; N-(4-((6,7-Dimethoxyquinolin-4-yl)Oxy)Phenyl)-N-(4-Fluoro-2-Hydroxyphenyl)Cyclopropane-1,1-Dicarboxamide; Cabozantinib Metabolite M9; Cabozantinib Impurity 78; Tributyl Acetylcitrate Impurity 1 (Tributyl Acetylcitrate Ep Impurity A)
CAS编号1628530-38-0
MFCD编号:MFCD34473108
FDA UNII编号:XU28OQ19RG
分子式:C28H24FN3O6分子量:517.51
产品CID: 824660
产品分类分析化学 → 标准品 → 药典标准品和杂质标准品

相似结构搜索
InChIKey: IMBCTWUTGHKFAD-UHFFFAOYSA-N
InChI=1S/C28H24FN3O6/c1-36-24-14-19-21(15-25(24)37-2)30-12-9-23(19)38-18-6-4-17(5-7-18)31-26(34)28(10-11-28)27(35)32-20-8-3-16(29)13-22(20)33/h3-9,12-15,33H,10-11H2,1-2H3
计算化学: 氢键受体数8.0氢键供体数3.0可旋转键数8.0

MSDS等安全信息

警示词Warning
危险描述H302-H315-H319-H335-
防范说明P261-P264-P270-P271-P280-P301+P312-P304+P340-P305+P351+P338-P330-P332+P313-P337+P313-P362-P403+P233-P405-P501-

上下游产品

1-({4-[(6,7-dimethoxyquinolin-4-yl)oxy]phenyl}carbamoyl)cyclopropane-1-carboxylic acid 2-amino-5-fluorophenol cyclopropane-1,1-dicarboxylic acid 1-(chlor°Carbonyl)cyclopropane-1-carboxylic acid

合成工艺路线路线简述

📜1,1-环丙基二羧酸置于氯化亚砜,1-羟基苯并三唑,三乙胺体系中,用四氢呋喃,乙腈用作溶剂,化学反应 16.0H,反应生成卡博替尼杂质65
参考文献: Dosing Of Cabozantinib Formulations[fr] Dosage De Préparations De Cabozantinib
标题: Dosing Of Cabozantinib Formulations[fr] Dosage De Préparations De Cabozantinib
摘要:该发明涉及对n-(4-{[6,7-双(甲氧基)喹啉-4-基]氧基}苯基)-N'-(4-氟苯基)环丙烷-1,1-二甲酰胺(卡博替尼)及其代谢物的各种药物制剂的管理,以实现理想的药代动力学和药效学效果.