CAS: 121776-33-8; 2,2-Dichloro-1-(5-(Furan-2-yl)-2,2-Dimethyloxazolidin-3-yl)Ethan-1-One

该化合物是其在有机溶剂中的中等溶性以及水溶性有限,这可能会影响其生物利用率和治疗效力. Furilazole已经研究其行动机制,其中可能涉及煽动途径的调制和和特定酶的抑制.此外,其安全特征和潜在副作用是其临床使用发展的重要考虑因素.与许多制药化合物一样,有必要进一步研究以充分阐明其药理学,药理动力学和治疗应用.

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CAS号2745-22-4 2-氨基-1-呋喃-2-乙醇 | CAS号79-36-7 二氯乙酰氯

合成工艺路线路线简述

  • 合成目标产物 Furilazole 主要起始原料 2-Amino-1-Furan-2-Yl-Ethanol
  • (文献来源)合成步骤主要原料 2-Amino-1-Furan-2-Yl-Ethanol
📜2-氨基-1-呋喃-2-基-乙醇置于sodium Hydroxide体系中,用 苯 用作溶剂,化学反应生成解草噁唑
参考文献:N-二氯乙酰基-5-芳基-1,3-恶唑烷的便捷一锅合成和生物活性
标题:N-二氯乙酰基-5-芳基-1,3-恶唑烷的便捷一锅合成和生物活性
摘要:摘要 通过芳基取代的羟烷基胺 1 与醛或酮 2 的环加成反应,然后酰化,无需分离中间产物 3,合成了新的 N-二氯乙酰基-5-芳基-1,3-恶唑烷 4. 化合物 4 的结构通过光谱和元素分析确定.4B 的结构是通过 X 射线晶体学分析确定的.生物测定结果表明,这些化合物可以减轻氯磺隆对玉米的损伤.
Doi:10.1515/hc-2013-0042

海关参考信息

专利信息


专利号:US-2021386068-A1
优先权日:2018-11-07
标题 :Compositions comprising pyridine carboxylate herbicides and very long chain fatty acid (vlcfa) synthesis inhibitor herbicides
发明人:KISTER JEREMY; SATCHIVI NORBERT M
权利人:CORTEVA AGRISCIENCE LLC
摘要:Disclosed herein are compositions comprising (a) a pyridine carboxylate herbicide or an agriculturally acceptable N-oxide, salt, or ester thereof and (b) a VLCFA synthesis inhibitor herbicide. Also disclosed herein are methods of controlling undesirable vegetation, comprising applying to vegetation or an area adjacent the vegetation or applying in soil or water to control the emergence or growth of vegetation (a) a pyridine carboxylate herbicide or an agriculturally acceptable N-oxide, salt, or ester thereof, and (b) a VLCFA synthesis inhibitor herbicide.

专利号:US-2021352899-A1
优先权日:2018-11-07
标题 :Compositions comprising pyridine carboxylate herbicides and fatty acid and lipid synthesis inhibitor herbicides
发明人:KISTER JEREMY; SATCHIVI NORBERT M
权利人:CORTEVA AGRISCIENCE LLC
摘要:Disclosed herein are compositions comprising (a) a pyridine carboxylate herbicide or an agriculturally acceptable N-oxide, salt, or ester thereof and (b) a fatty acid and lipid synthesis inhibitor (FA/LSI) herbicide, an agriculturally acceptable salt or ester thereof, or mixtures thereof. Also disclosed herein are methods of controlling undesirable vegetation, comprising applying to vegetation or an area adjacent the vegetation or applying in soil or water to control the emergence or growth of vegetation (a) a pyridine carboxylate herbicide or an agriculturally acceptable N-oxide, salt, or ester thereof and (b) a fatty acid and lipid synthesis inhibitor (FA/LSI) herbicide, an agriculturally acceptable salt or ester thereof, or mixtures thereof.

专利号:ES-2717283-T3
优先权日:2012-07-24
标 题:Herbicidal compositions comprising 4-amino-3-chloro-5-fluoro-6- (4-chloro-2-fluoro-3-methoxyphenyl) pyridine-2-carboxylic acid or a derivative thereof and herbicides inhibitors of VLCFA synthesis and synthesis of fatty acids / lipids

专利号:TW-I655905-B
优先权日:2012-07-24
标题 :Contains 4-amino-3-chloro-5-fluoro-6-(4-chloro-2-fluoro-3-methoxyphenyl)pyridine-2-carboxylic acid or a derivative thereof and very long chain fatty acid (VLCFA) Synthesis of herbicidal compositions with fatty acid/fat synthesis inhibiting herbicides

专利号:US-9644469-B2
优先权日:2012-07-24
标题 :Herbicidal compositions comprising 4-amino-3-chloro-5-fluoro-6-(4-chloro-2-fluoro-3-methoxyphenyl) pyridine-2-carboxylic acid or a derivative thereof and VLCFA and lipid synthesis inhibiting herbicides
发明人:YERKES CARLA N; MANN RICHARD K; SHIRAISHI IKUO; YANAGIYAMA SHINGO; SATCHIVI NORBERT M
权利人:DOW AGROSCIENCES LLC
摘要:A synergistic herbicidal composition containing (a) a compound of formula (I): n nor an agriculturally acceptable salt or ester thereof and (b) VLCFA and fatty acid/lipid synthesis inhibiting herbicides, including but not limited to, acetochlor, alachlor, anilofos, benfuresate, cafenstrole, dimethenamid-P, fentrazamide, indanofan, flufenacet, mefenacet, s-metolachlor, molinate, pethoxamid, pretilachlor, prosulfocarb, pyroxasulfone, thenylchlor and thiobencarb, or a salt or ester thereof, provide synergistic weed control of undesirable vegetation in direct-seeded, water-seeded and transplanted rice, cereals, wheat, barley, oats, rye, sorghum, corn or maize, sugarcane, sunflower, oilseed rape, canola, sugar beet, soybean, cotton, pineapple, pastures, grasslands, rangelands, fallowland, turf, tree and vine orchards, aquatics, plantation crops, vegetables, industrial vegetation management (IVM) or rights-of-way (ROW).

专利号:US-9999223-B2
优先权日:2008-05-21
标 题 :Herbicidal composition comprising glyphosate, glufosinate or their salts
发明人:SIEVERNICH BERND; MOBERG WILLIAM KARL; SIMON ANJA; WALTER HELMUT; EVANS RICHARD R
权利人:BASF SE
摘要:The present invention relates to a herbicidal composition which comprises:n a) at least one herbicide A selected from glyphosate, glufosinate and their salts, and b) a herbicide B which is 3-[5-(difluoromethoxy)-1-methyl-3-(trifluoromethyl)pyrazol-4-ylmethylsulfonyl]-4,5-dihydro-5,5-dimethyl-1,2-oxazole [common name: pyroxasulfone]. nn The present invention relates in particular to a herbicidal composition comprising:n a) at least one herbicide A selected from glyphosate, glufosinate and their salts, b) a herbicide B which is 3-[5-(difluoromethoxy)-1-methyl-3-(trifluoromethyl)pyrazol-4-ylmethylsulfonyl]-4,5-dihydro-5,5-dimethyl-1,2-oxazole [common name: pyroxasulfone], and c) at least one further herbicide C, which is selected from the herbicide groups C.1 to C.8:n C.1 herbicides of the group of acetolactate synthase inhibitors (ALS inhibitors), C.2 herbicides of the group of protoporphyrinogen oxidase inhibitors (PPO inhibitors), C.3 herbicides of the group of auxines, C.4 herbicides of the group of 4-hydroxyphenyl-pyruvate-dioxygenase inhibitors (HPPD inhibitors), C.5 herbicides of the group of phytoene desaturase inhibitors (PDS inhibitors), C.6 herbicides of the group of photosystem II inhibitors (PSII inhibitors), C.7 herbicides of the group of microtubulin inhibitors, and C.8 herbicides of the group of inhibitors of the synthesis of very long chain fatty acids (VLCFA inhibitors).

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✅ COA系统入驻 | 共享模式

合成参考文献


参考文献:10.3103/s106836742307039x
摘要:Zorkina OV, Sukhova EA, Agapova OO, Nefedieva EE, Gribust IR, Kolotova OV. Compositions of Fungicides with Growth Regulators That Reduce the Retarding Effect of Crop Protectants. Russ. Agricult. Sci. 2023 Dec;49(S1):S118–24. doi: 10.3103/s106836742307039x.
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