专利号:US-11548898-B2 优先权日:2017-07-06 标题 :Synthesis of halichondrins 发明人:KISHI YOSHITO; AI YANRAN; YE NING; WANG QIAOYI; YAHATA KENZO; ISO Kentaro; NAINI SANTHOSH REDDY; YAMASHITA SHUJI; LEE JIHOON; OHASHI ISAO; FUKUYAMA TAKASHI 权利人:HARVARD COLLEGE; EISAI R&D MAN CO LTD 摘要:The present invention provides methods for the synthesis of ketones involving a Ni/Zr-mediated coupling reaction. The Ni/Zr-mediated ketolization reactions can be used in the synthesis of halichondrins (e.g., halichondrin A, B, C; homohalichondrin A, B, C; norhalichondrin A, B, C), and analogs thereof. Therefore, the present invention also provides synthetic methods useful for the synthesis of halichondrins, and analogs thereof. Also provided herein are compounds (i.e., intermediates) useful in the synthesis of halichondrins, and analogs thereof. In particular, the present invention provides methods and compounds useful in the synthesis of compound of Formula (H3-A).
专利号:US-7615169-B2 优先权日:2004-09-20 标题 :Method for synthesis of colloidal nanoparticles 发明人:STROUSE GEOFFREY FIELDING; GERBEC JEFFREY A; MAGANA DONNY 权利人:UNIV CALIFORNIA 摘要:A method for synthesis of high quality colloidal nanoparticles using comprises a high heating rate process. Irradiation of single mode, high power, microwave is a particularly well suited technique to realize high quality semiconductor nanoparticles. The use of microwave radiation effectively automates the synthesis, and more importantly, permits the use of a continuous flow microwave reactor for commercial preparation of the high quality colloidal nanoparticles.
专利号:US-7927516-B2 优先权日:2004-09-20 标题 :Method for synthesis of colloidal nanoparticles 发明人:STROUSE GEOFFREY F; GERBEC JEFFREY A; MAGANA DONNY 权利人:UNIV CALIFORNIA 摘要:A method for synthesis of high quality colloidal nanoparticles using comprises a high heating rate process. Irradiation of single mode, high power, microwave is a particularly well suited technique to realize high quality semiconductor nanoparticles. The use of microwave radiation effectively automates the synthesis, and more importantly, permits the use of a continuous flow microwave reactor for commercial preparation of the high quality colloidal nanoparticles.
专利号:WO-2024201393-A1 优先权日:2023-03-29 标 题:Methods for the synthesis of nucleoside analogues and nucleosides analogues derived therefrom 发明人:BRITTON ROBERT; Muir Garrett; ANKETELL MATTHEW JAMES; HUXLEY COHAN; BAIKABI SUPING 权利人:UNIV FRASER SIMON 摘要:The present invention relates to methods for the synthesis of nucleoside analogues. More specifically, the present invention relates to methods for the synthesis of C4' substituted nucleoside analogues via the reaction of a soft nucleophile with a halohydrin ketone.
专利号:WO-2022034429-A1 优先权日:2020-08-10 标 题 :PROCESS OF SYNTHESIS OF β-6'SULFOQUINOVOSYL DIACYLGLYCEROLS 发明人:MANZO EMILIANO; FONTANA ANGELO; ZIACO MARCELLO 权利人:BIOSEARCH S R L 摘要:The present invention relates to a synthesis process of β-6-sulfoquinovosyl-diacylglycerols. In particular, said process is for the synthesis of the compounds 1,2-O-distearoyl-3-O-(β- sulfoquinovosyl)- R/S -glycerol, 1,2-O-distearoyl-3-O-(β-sulfoquinovosyl)- R -glycerol or 1,2- O-distearoyl-3-O-(β-sulfoquinovosyl)- S -glycerol, named respectively Sulfavant A, Sulfavant R and Sulfavant S.
专利号:US-10011580-B2 优先权日:2016-04-21 标题:Diastereoselective synthesis of (±)-epianastrephin, (±)-anastrephin and analogs thereof 发明人:WALSE SPENCER S; KUZMICH DANIEL 权利人:US AGRICULTURE 摘要:A process for the synthesis of trans-fused γ-lactones having Formula (IV) from substituted cyclic ketones having Formula (I). A diastereoselective synthesis of (±)-epianastrephin (1) (wherein: R 1 is ethenyl, R 2 and R 3 is methyl, and n is 1), (±)-anastrephin (2) (wherein: R 2 is ethenyl, R 1 and R 3 is methyl and n is 1), and analogs thereof (wherein: R 1 is H, C 1-5 alkyl, C 2-6 alkenyl or C 2-6 alkynyl, R 2 is H, C 1-5 alkyl, C 2-6 alkenyl or C 2-6 alkynyl, R 1 and R 2 together with the carbon atom they are attached form a C 3-6 cycloalkyl ring, R 3 is C 1-5 alkyl and n is 0-2):
参考标题:Methylindium Dialkylamido Compounds: Mono- And Bis-Dialkylamides Involving Four- And Five-Co-Ordinated Indium(III). X-Ray Crystal Structures Of {me2In[n(Ch2)2N(Me)Ch2Ch2]}2, Mein[menc(Ch)4N]2, And Mein{[men(Ch2)2Nme]Inme2}2 作者:Atta M. Arif,Donald C. Bradley,Helen Dawes,Dario M. Frigo,Michael B. Hursthouse,Bilquis Hussain 摘要:(Me2Inl)2[l = [graphic Omitted]H2(1), N(C6H11)2(2), And [graphic Omitted]Hme (3)] Is Reported. The X-Ray Crystal Structure Of (1) Shows An Amido-Bridged Dimer; All The Compounds Appear As Dimers In The Mass Spectra. Variable-Temperature 1H N.M.R. Of (3) Shows That It Exists As Two Conformational Isomers Which Do Not Interconvert At Room Temperature. The Synthesis Of Mein[men[graphic Omitted]]2(4) And
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