CAS: 98946-18-0; Tert-Butyl Trichloroacetimidate

相似化合物

99418-52-7 2533-69-9 51479-73-3

上下游产品

CAS号545-06-2 三氯乙腈 | CAS号75-65-0 叔丁醇 | CAS号865-47-4 叔丁醇钾 | CAS号14437-51-5 z-thr(tbu)-otbu | CAS号72289-51-1 z-thr-otbu | CAS号2109-72-0 1-叔丁氧基-4-硝基苯 | CAS号2901-11-3 Benzeneacetic a... | CAS号301180-04-1 1-Benzyl 3-tert... | CAS号24356-14-7 tert-butyl 2-br... | CAS号97347-28-9 Nα,Nε-双-双-b°C-L... | CAS号5292-43-3 溴乙酸叔丁酯 | CAS号594-65-0 2,2,2-三氯乙酰胺

三氯乙腈,叔丁醇置于sodium T-Butanolate体系中,用 正庚烷 作为反应溶剂,化学反应 2.0H,反应生成 叔丁基三氯乙酰亚胺酯
参考文献:具挑战性的对转异构hiv整合酶抑制剂的简洁实用的不对称合成.
标题:具挑战性的对转异构hiv整合酶抑制剂的简洁实用的不对称合成.
摘要:已经完成了一种实用有效的合成方法,用于合成复杂的手性阻转异构hiv整合酶抑制剂.铜催化的酰化与bi-Dime配体的结合使配体可控的suzuki交叉偶联以及前所未有的双(三氟甲烷)磺酰胺催化的叔丁基化相结合,使该复杂分子的合成稳定,安全且经济.此外,相对于嵌入的阻转异构体,以不对称和非对映选择性的方式进行整体合成.
DOI:10.1002/anie.201501575

专利信息

专利号:EP-3515880-B1
优先权日:2017-03-17
标题:Methods and compositions for synthesis of encoded libraries
发明人：LI JIN; MORGAN BARRY A; Wan jinqiao; DOU DENGFENG; LIU GUANSAI; CHANG YONG; CHEN QIUXIA; WANG XING; XU YANSHAN; HU DONGYAN; LIU JIAN; CHENG XUEMIN
权利人:HITGEN INC

专利号:US-10017481-B2
优先权日:2012-03-17
标 题 :Conformationally constrained, fully synthetic macrocyclic compounds
发明人：OBRECHT DANIEL; ERMERT PHILIPP; OUMOUCH SAID; PIETTRE ARNAUD; GOSALBES JEAN-FRANÇOIS; THOMMEN MARC
权利人:POLYPHOR AG
摘要:The conformationally restricted, spatially defined macrocyclic ring system of formula (I) is constituted by three distinct molecular parts: Template A, conformation Modulator B and Bridge C. Macrocycles described by this ring system I are readily manufactured by parallel synthesis or combinatorial chemistry in solution or on solid phase. They are designed to interact with a variety of specific biological target classes, examples being agonistic or antagonistic activity on G-protein coupled receptors (GPCRs), inhibitory activity on enzymes or antimicrobial activity. In particular, these macrocycles show inhibitory activity on endothelin converting enzyme of subtype 1 (ECE-1) and/or the cysteine protease cathepsin S (CatS), and/or act as antagonists of the oxytocin (OT) receptor, thyrotropin-releasing hormone (TRH) receptor and/or leukotriene B4 (LTB4) receptor, and/or as agonists of the bombesin 3 (BB3) receptor, and/or show antimicrobial activity against at least one bacterial strain. Thus they are showing great potential as medicaments for a variety of diseases.

专利号:US-8722014-B2
优先权日:2009-05-01
标题 :1 H-[1, 2, 3] triazole substituted amino acids and uses thereof
发明人：MACH ROBERT H; MCCONATHY JONATHAN
权利人:MACH ROBERT H; MCCONATHY JONATHAN; UNIV WASHINGTON
摘要:Tracers for cationic amino acid transport systems and methods of synthesis are disclosed, including compounds comprising a 1H-[1,2,3]triazole moiety. Further disclosed are uses of the analogues, including in vivo imaging of tumors by Positron emission tomography (PET) or Single Photon Emission Computed Tomography (SPECT).

专利号:US-2025108123-A1
优先权日:2021-12-17
标 题:Compound-linker constructs comprising novel compounds useful as sting agonists and uses thereof
发明人：YE YANG; LI XIUWEI; YANG GUIQUN; WANG HONGLING; FANG XIONG; CUI YANKAI; YAN FASHUN; SONG BINHUA
权利人:JACOBIO PHARMACEUTICALS CO LTD
摘要:Provided herein are compound-linker constructs and antibody-drug-conjugates of compounds of formula (Y-1), (Y-2), (Y-3), (A), (B), (C), I, II, III, IV or V that are useful as modulators of STING (Stimulator of Interferon Genes). Also provided are synthesis, compositions and uses of such compound-linker constructs and antibody-drug-conjugates.

专利号:CN-120574133-A
优先权日:2025-05-27
标题 :Synthesis method of tert-butyl 4-bromobutyrate

专利号:CN-106957357-A
优先权日:2017-04-01
标 题:A kind of scorpion toxin polypeptide and its synthesis method