专利号:US-9409879-B2 优先权日:2011-03-29 标 题 :Total synthesis of redox-active 1.4-naphthoquinones and their metabolites and their therapeutic use as antimalarial and schistomicidal agents 发明人:DAVIOUD-CHARVET ELISABETH; LANFRANCHI DON ANTOINE; JOHANN LAURE; WILLIAMS DAVID LEE; CESAR RODO ELENA 权利人:DAVIOUD-CHARVET ELISABETH; LANFRANCHI DON ANTOINE; JOHANN LAURE; WILLIAMS DAVID LEE; CESAR RODO ELENA; CENTRE NAT RECH SCIENT 摘要:Naphthoquinones, azanaphthoquinones and benxanthones, their process of synthesis and methods of their use as antimalarial or antischistosomal agents.
专利号:US-2004110228-A1 优先权日:2002-04-01 标 题:Combinatorial organic synthesis of unique biologically active compounds 发明人:MCALPINE SHELLI R; TAYLOR RACHEL E; BOLLA MEGAN L; SEGALL ANCA M 摘要:The invention provides a method for making a combinatorial library of cyclic compounds, such as Holliday junction-trapping compounds, comprising the steps of (a) obtaining a plurality of trimers according to the generic structure X 1- X 2- X 3 , wherein X 1 , X 2 and X 3 can be independently any naturally or nonnaturally occurring amino acids or peptidomimetics thereof; (b) optionally coupling a spacer S to the trimer at either end; (c) cyclizing two trimers or trimer-spacer conjugates in a head-to-tail orientation; thereby obtaining a combinatorial library of compounds, wherein the library does not include an unmodifed or naturally occurring Holliday Junction-trapping compounds. The invention additionally provides methods macrocyclic compounds that are synergimycin derivatives.
专利号:US-9725392-B2 优先权日:2015-08-27 标 题:Efficient scalable syntheses of abscisic acid, 8′-acetylene abscisic acid and 8′-cyclopropyl abscisic acid 发明人:JHEENGUT Vishal; NELSON KEN M; ABRAMS SUZANNE R 权利人:NAT RES COUNCIL CANADA 摘要:Methods are provided for synthesis of abscisic acid and 8′ analogues thereof (including an enantiopure 8′-acetylene analogue) including methods wherein the previously reported first step of oxidation of 2,6-dimethylphenol (VI) to 2,6-dimethylbenzoquinone, mono ketal (VII) is replaced by a novel two step process comprising (i) oxidation of 2,6-dimethylphenol (VI) using potassium peroxymonosulfate with a catalytic amount of iodobenzene to produce 2,6-dimethylbenzoquinone (XVI) and (ii) ketalization of 2,6-dimethylbenzoquinone (XVI) using ethylene glycol, trimethylorthoformate with a catalytic amount of p-toluenesulfonic acid to produce 2,6-dimethylbenzoquinone, mono ketal (VII).
专利号:US-9051656-B2 优先权日:2009-07-23 标题 :Electrochemical synthesis of aryl-alkyl surfacant precursor 发明人:BHAVARAJU SAI; KARANJIKAR MUKUND; CHITTA PALLAVI 权利人:BHAVARAJU SAI; KARANJIKAR MUKUND; CHITTA PALLAVI; CERAMATEC INC 摘要:An aryl-alkyl (R—Ar) hydrocarbon is prepared by an electrosynthesis process in an electrolytic cell having an alkali ion conductive membrane positioned between an anolyte compartment configured with an anode and a catholyte compartment configured with a cathode. An anolyte solution containing an alkali metal salt of an alkyl carboxylic acid and an aryl compound is introduced into the anolyte compartment. The aryl compound may include an alkali metal salt of an aryl carboxylic acid, an arene (aromatic) hydrocarbon, or an aryl alkali metal adduct (Ar − M + ). The anolyte solution undergoes electrolytic decarboxylation to form an alkyl radical. The alkyl radical reacts with the aryl compound to produce the aryl-alkyl hydrocarbon.
专利号:US-5670698-A 优先权日:1996-08-19 标 题:Synthesis of 1-acetoxy-2-methylnaphthalene 发明人:LIM MU-ILL; PAN YUH-GUO; STASAITIS LINAS; ANDERSON JAMES 权利人:BRISTOL MYERS SQUIBB CO 摘要:A one pot process is provided in which a Mannich base of the formula 5 is reacted with acetic anhydride to produce a diacetate derivative. Without any intermediate isolation, the derivative is hydrogenated to produce a reaction mixture containing 1-acetoxy-2-methylnaphthalene which is readily precipitated from the reaction mixture by addition of water. ##STR1##
专利号:RU-2196764-C2 优先权日:2001-03-26 标 题:Method of synthesis of substituted quinones, catalyst for its realization and method of catalyst synthesis
参考标题:Ruthenium-Catalyzed Aromatization Of Enediynes Via Highly Regioselective Nucleophilic Additions On A π-Alkyne Functionality. A Useful Method For The Synthesis Of Functionalized Benzene Derivatives 作者:Arjan Odedra,Chang-Jung Wu,Taduri Bhanu Pratap,Chun-Wei Huang,Ying-Fen Ran,Rai-Shung Liu |发布日期:2005.3.1 摘要:Tpru(Pph3)(Ch3Cn)2 Pf6 (10 Mol %) Catalyst Effected The Nucleophilic Addition Of Water, Alcohols, Aniline, Acetylacetone, Pyrroles, And Dimethyl Malonate To Unfunctionalized Enediynes Under Suitable Conditions (100 Degrees C, 12-24 H) And Gave Functionalized Benzene Products In Good Yields. In This Novel Cyclization, Nucleophiles Very Regioselectively Attack The Internal C1' Alkyne Carbon Of Enediynes
合成参考文献
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