CAS: 73575-54-9; 2,2',3,6,6'-Pentachlorobiphenyl

该化合物是一种多氯联苯(PCB)同族体,其特征是:在双苯结构的2,2',3,6,6和6位置上,有5种氯替代物,该化合物主要用于研究和分析应用,因其持久性和生物累积性,作为环境与毒理学研究的参考标准.其定义明确的氯化模式使得它对于色谱校准和多氯联苯污染分析很有价值.该化合物的稳定性和降解耐受性使得实验室环境能够保持连续性,有利于对多氯联苯行为,代谢途径和环境影响的研究. 妥善处理由于其潜在的毒性和监管限制,是至关重要的.

英文名称2,2',3,6,6'-Pentachlorobiphenyl
中文名称2,2’,3,6,6’-戊氯联苯
IUPAC名称1,2,4-trichloro-3-(2,6-dichlorophenyl)benzene
其它别名2,2',3,6,6'-Pentachlorobiphenyl; PCB 96
CAS编号73575-54-9
MFCD编号:MFCD00661149
FDA UNII编号:K42VE4HVAP
分子式:C12H5Cl5分子量:326.43
产品CID: 1722986
产品分类分析化学 → 食品安全 → 二噁英，多氯联苯，呋喃

相似结构搜索
产品信息参考;;;;
InChIKey: QQFGAXUIQVKBKU-UHFFFAOYSA-N
1S/C12H5Cl5/c13-6-2-1-3-7(14)10(6)11-8(15)4-5-9(16)12(11)17/h1-5H
计算化学: 氢键受体数*氢键供体数*可旋转键数1.0

MSDS等安全信息

危险描述Not Classified
Reported as not meeting GHS hazard criteria by 3 of 3 companies. For more detailed information, please visit ECHA C&L website.
安全声明The mechanism of action varies with the specific PCB. Dioxin-like PCBs bind to the aryl hydrocarbon receptor, which disrupts cell function by altering the transcription of genes, mainly be inducing the expression of hepatic Phase I and Phase II enzymes, especially of the cytochrome P450 family. Most of the toxic effects of PCBs are believed to be results of Ah receptor binding. Other PBCs are believed to interfere with calcium channels and/or change brain dopamine levels. PCBs can also cause endocrine disurption by altering the production of thyroid hormones and binding to estrogen receptors, which can stimulate the growth of certain cancer cells and produce other estrogenic effects, such as reproductive dysfunction. They will bioaccumulate by binding to receptor proteins such as uteroglobin. (A3, A4, A30, A66)

上下游产品

2,2',3,3',6,6'-hexachlorobiphenyl 2,2',6,6'-tetrachlorobiphenyl

合成工艺路线路线简述

📜2,6-二氯苯胺置于三氯化铝,磺酰氯,硫酸,铜,Potassium Iodide,Sodium Nitrite体系中,用二氯甲烷作为反应溶剂,化学反应 290.42H,反应生成 2,2',3,6,6'-戊氯联苯
参考文献:Improved Syntheses Of 2,2',3,3',6,6'-Hexachlorobiphenyl
标题:Improved Syntheses Of 2,2',3,3',6,6'-Hexachlorobiphenyl
摘要:
DOI:10.1080/00304949709355248