CAS: 703-80-0; 3-Acetylindole

该化合物是多用途有机化合物,其特点是其不道德和氯酮功能.该化合物具有高度纯度和稳定性,适合各种合成应用.其独特的结构允许有效参与有机转化,为合成复杂分子提供了广阔的空间.该化合物在不同等级的可用性确保了研究和开发工作的灵活性.

结构式图片

欧盟法规

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上下游产品

3-(1H-吲哚-3-基)-3-氧丙腈 3-(1H-Indol-3-yl)-3-Oxo-Propionitrile 20356-45-0
(3-(3-Methyl-1-Oxo-2-Butenyl))-1H-Indole 50615-00-4
1,3-二(1H-吲哚-3-基)丙烷-1,3-二酮 1,3-Di(1H-Indol-3-yl)Propane-1,3-Dione 871889-42-8
3-(1H-吲哚-3-基)-3-氧丙酸乙酯 Ethyl 3-(1H-Indol-3-yl)-3-Oxopropanoate 52816-02-1
3-异丙基-1H-吲哚 3-Isopropyl Indole 16886-00-3
1-(1H-吲哚-3-基)-乙醇 1-(1H-Indol-3-yl)Ethan-1-Ol 103205-15-8
1-(3-氯丙基)-3-乙酰基吲哚 1-(3-Chloropropyl)-3-Acetylindole 156237-49-9
3-Chloroacetyl-1-Methoxyindole 98258-81-2
1-(1-苄基-1H-吲哚-3-基)乙酮 3-Acetyl-1-Benzyl-1H-Indole 93315-38-9
1,3-二乙酰基吲哚 1,3-Diacetyl-1H-Indole 17537-64-3

合成工艺路线路线简述

    4-(2-Azido-Phenyl)-But-3-En-2-One置于bis{rhodium[3,3'-(1,3-Phenylene)Bis(2,2-Dimethylpropanoic Acid)]}体系中,用 甲苯 作为反应溶剂,化学反应 16.0H,以65%的收率获得产物3-乙酰吲哚
    参考文献:Rh2(II)-Catalyzed Nitro-Group Migration Reactions: Selective Synthesis Of 3-Nitroindoles From β-Nitro Styryl Azides
    标题:Rh2(II)-Catalyzed Nitro-Group Migration Reactions: Selective Synthesis Of 3-Nitroindoles From β-Nitro Styryl Azides
    摘要:Rhodium Carboxylate Complexes (1 Mol %) Catalyze The Migration Of Electron-Withdrawing Groups To Selectively Produce 3-Substituted Indoles From Beta-Substituted Styryl Azides. The Relative Order Of Migratorial Aptitude For This Transformation Is Ester << Amide < H < Sulfonyl < Benzoyl << Nitro.
    DOI:10.1021/ja111060Q

    海关参考信息

    专利信息


    专利号:US-6951878-B2
    优先权日:1998-03-12
    标 题:Benzo[b]thiophenyl or tetrahydro-benzo[b]thiophenyl modulators of protein tyrosine phosphatases (PTPases)
    发明人:MOELLER NIELS PETER HUNDAHL; ANDERSEN HENRIK SUNE; IVERSEN LARS FOGH; OLSEN OLE HVILSTED; BRANNER SVEN; HOLSWORTH DANIEL DALE; BAKIR FARID; JUDGE LUKE MILBURN; AXE FRANK URBAN; JONES TODD KEVIN; RIPKA WILLIAM CHARLES; GE YU; UYEDA ROY TERUYUKI
    权利人:NOVO NORDISK AS
    摘要:The present invention provides novel compounds, novel compositions, methods of their use, and methods of their manufacture, where such compounds are pharmacologically useful inhibitors of Protein Tyrosine Phosphatases (PTPase's) such as PTP1B, CD45, SHP-1, SHP-2, PTPα, LAR and HePTP or the like. n The compounds are useful in the treatment of type I diabetes, type II diabetes, impaired glucose tolerance, insulin resistance, obesity, immune dysfunctions including autoimmunity diseases with dysfunctions of the coagulation system, allergic diseases including asthma, osteoporosis, proliferative disorders including cancer and psoriasis, diseases with decreased or increased synthesis or effects of growth hormone, diseases with decreased or increased synthesis of hormones or cytokines that regulate the release of/or response to growth hormone, diseases of the brain including Alzheimer's disease and schizophrenia, and infectious diseases.

    专利号:US-7737287-B2
    优先权日:2002-03-28
    标 题 :Anomeric derivatives of monosaccharides
    发明人:MEUTERMANS WIM; WEST MICHAEL LEO; GIANG THANH LE; ADAMSON GEORGE; SCHAFER KARL; ABBENANTE GIOVANNI
    权利人:ALCHEMIA LTD
    摘要:This invention relates to combinatorial libraries of potentially biologically active mainly monosaccharide compounds and to methods of preparing same. These compounds are variously functionalized, with a view to varying lipid solubility, size, function and other properties, with the particular aim of discovering a drug or drug-like compound, or compounds with useful properties. The invention provides intermediates, processes and synthetic strategies for the solution or solid phase synthesis of monosaccharides, variously functionalized about the sugar ring, including the addition of aromaticity and charge, and the placement of amino acid and peptide side chain units of isosteres thereof.

    专利号:US-2009227701-A1
    优先权日:2004-08-19
    标题:Water-soluble, radiation-curable products and use thereof
    发明人:KRUEGER CHRISTIAN; BRUCHMANN BERND; HEES ULRIKE; KLUGE MICHAEL; DIELEMAN CEDRIC; WEISER JUERGEN
    权利人:BASF AG
    摘要:Water soluble radiation curable products (A) obtainable by mixingn mixing with or without reaction of at least one hyperbranched polyurethane (a) with at least one photoinitiator (b) or by synthesis of at least one hyperbranched polyurethane (a) in the presence of at least one photoinitiator (b),n nare used to produce aqueous inks for the ink jet process.

    专利号:CA-2506422-A1
    优先权日:2002-11-22
    标题 :Enzymatic synthesis of polyol acrylates

    专利号:EP-1565563-B1
    优先权日:2002-11-22
    标题:Enzymatic synthesis of polyol acrylates
    发明人:PAULUS WOLFGANG; HAUER BERNHARD; HAERING DIETMAR; DIETSCHE FRANK
    权利人:BASF SE

    专利号:US-2006030013-A1
    优先权日:2002-11-22
    标题 :Enzymatic synthesis of polyol acrylates
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    主要参考文献


    1: Billes F, Podea PV, Mohammed-Ziegler I, Toşa M, Mikosch H, Irimie DF. Formyl- and acetylindols: vibrational spectroscopy of an expectably pharmacologically active compound family. Spectrochim Acta A Mol Biomol Spectrosc. 2009 Dec;74(5):1031-45. doi: 10.1016/j.saa.2009.08.044. Epub 2009 Aug 28. doi: 10.1016/j.bmcl.2010.04.132. Epub 2010 May 18. doi: 10.1016/j.saa.2014.06.043. Epub 2014 Jun 14. doi: 10.1107/S0108270108017733. Epub 2008 Jun 21. doi: 10.1039/c2ob25348h. Epub 2012 Apr 3.

    合成参考文献


    摘要:Joule, J. A., Science of Synthesis Knowledge Updates, (2010) 2, 186.
    摘要:Joule, J. A., Science of Synthesis Knowledge Updates, (2010) 2, 244.
    摘要:Joule, J. A., Science of Synthesis Knowledge Updates, (2018) 2, 157.
    摘要:Harris, P. A., Science of Synthesis Knowledge Updates, (2021) 3, 18.
    摘要:Joule, J. A., Science of Synthesis Knowledge Updates, (2018) 2, 265.
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