2,2-二氯-5-甲基苯并[d][1,3]二氧杂环戊烯置于盐酸,N-溴代丁二酰亚胺(Nbs),Potassium Bromide,过氧化苯甲酰体系中,用 1,4-二氧六环,四氯化碳,Ice-Water,水 作为反应溶剂,化学反应生成 (2,2-二氟-苯并[1,3]二氧代l-5-基)-乙腈 参考文献:Insecticidal And Acaricidal M-Phenoxybenzyl Esters Of 标题:Insecticidal And Acaricidal M-Phenoxybenzyl Esters Of 摘要:这项发明涉及2,2-二氟-1,3-苯并二氧杂环戊烷-5-(α-烷基)乙酸的新型m-苯氧基苄酯,其制备方法,以及利用这些化合物控制昆虫和螨虫的方法.
专利号:EP-3835297-B1 优先权日:2010-03-25 标题:Synthesis and intermediates of (r)-1(2,2 -difluorobenzo[d][1,3]dioxol-5yl)-n-(1-(2,3-dihydroxypropyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2yl)-1h-indol-5yl)cyclopropanecarboxamide 发明人:KESHAVARZ-SHOKRI ALI; ZHANG BEILI; ALCACIO TIM EDWARD; LEE ELAINE CHUNGMIN; ZHANG YUEGANG; KRAWIEC MARIUSZ 权利人:VERTEX PHARMA
专利号:US-4405639-A 优先权日:1978-08-28 标 题:Combating arthropods with fluorine-containing phenylacetic acid esters 发明人:FUCHS RAINER; KLAUKE ERICH; HAMMANN INGEBORG; HOMEYER BERNHARD; BEHRENZ WOLFGANG; STENDEL WILHELM; LANTZSCH REINHARD; MARHOLD ALBRECHT 权利人:BAYER AG 摘要:Fluorine-containing phenylacetic acid esters of the formula (I) in which R represents the radical of an alcohol customary in the case of pyrethroids, R1 represents C2-4-alkyl, C2-4-alkenyl or cyclopropyl, X represents H, halogen, alkyl, alkoxy, OCHF2, SCHF2, SCClF2 or SCF3 and X1 can vary widely or form a fused ring with X, the overall compound necessarily containing a fluorine atom, which compounds possess arthropodicidal properties. Intermediates therefor and an overall synthesis from an alcohol of the formula ROH and a toluene of the formula are also shown.
专利号:EP-3835297-A1 优先权日:2010-03-25 标题 :Synthesis and intermediates of (r)-1(2,2 -difluorobenzo[d][1,3]dioxol-5yl)-n-(1-(2,3-dihydroxypropyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2yl)-1h-indol-5yl)cyclopropanecarboxamide