专利号:US-2011319644-A1 优先权日:2006-11-02 标 题:Process for production of 1-hydroxy-19-norcyclovitamin d derivative and intermediate for the production 发明人:TOYODA ASAKO; NAGAI HAZUKI; KONUKI KANAME; TSUCHIDA TOSHIO 权利人:TOYODA ASAKO; NAGAI HAZUKI; KONUKI KANAME; TSUCHIDA TOSHIO 摘要:A cyclovitamin D derivative produced from 25-hydroxyvitamin D is reacted with osmium tetraoxide or a permanganic acid salt to produce a 10,19-diolcyclovitamin D derivative. The 10,19-diolcyclovitamin D derivative is reacted with a perhalogenic acid salt or lead tetraacetate to produce a 10-oxocyclovitamin D derivative. A 1-hydroxycyclovitamin D derivative is produced from the 10-oxocyclovitamin D derivative via a cyclovitamin D derivative and a 1,10-olefincyclovitamin D derivative. The 1-hydrocyclovitamin D derivative is subjected to solvolysis, thereby producing a 1-hydroxy-19-norviatmin D derivative. Thus provided are a novel process for production of 1-hydroxy-19-norcyclovitamin D derivative that is utilizable as an intermediate in the synthesis of 1-hydroxy-19-norvitamin D derivative which is useful as a pharmaceutical agent; and an intermediate for the production.
专利号:WO-2014093723-A2 优先权日:2012-12-12 标 题 :Group-assistant-purification (gap) synthesis of velcade, dimeric analogs, and amino compounds 发明人:LI GUIGEN 权利人:NANJING UNIVERSITY OF TECHNOLOGY
专利号:US-3113132-A 优先权日:1961-03-17 标 题:Synthesis of chlorinated alkylpyrazines 发明人:BAXTER GEORGE E; LEVIS JR WILLIAM W 权利人:WYANDOTTE CHEMICALS CORP
专利号:US-2008176865-A1 优先权日:2005-06-15 标 题:Substituted arylpyrazoles 发明人:BILLEN DENIS; BOYLE JESSICA; CRITCHER DOUGLAS JAMES; GETHIN DAVID MORRIS; HALL KIM THOMAS; KYNE GRAHAM MICHAEL 权利人:PFIZER LTD 摘要:This invention relates to a range of 1-aryl-4-cyclopropylpyrazoles in which the cyclopropyl ring is substituted at the angular position, and pharmaceutically acceptable salts and solvates thereof, to compositions comprising such compounds, processes to their synthesis and their use as parasiticides.
专利号:CN-107827827-A 优先权日:2017-12-13 标题:A kind of synthesis technique of 2,5-dimethylol-3,6-dimethylpyrazine
专利号:US-7968584-B2 优先权日:2005-06-15 标 题:Substituted arylpyrazoles 发明人:BILLEN DENIS; BOYLE JESSICA; CRITCHER DOUGLAS JAMES; GETHIN DAVID MORRIS; HALL KIM THOMAS; KYNE GRAHAM MICHAEL 权利人:PFIZER; PFIZER PROD INC 摘要:This invention relates to a range of 1-aryl-4-cyclopropylpyrazoles in which the cyclopropyl ring is substituted at the angular position, and pharmaceutically acceptable salts and solvates thereof, to compositions comprising such compounds, processes to their synthesis and their use as parasiticides.
摘要:Toxicology and Applied Pharmacology., 17(244), 1970 [] 参考文献:10.1007/s10886-021-01324-4 摘要:Bohman B, Tan MMY, Flematti GR, Peakall R. Drakolide Structure-activity Relationships for Sexual Attraction of Zeleboria Wasp Pollinator. Journal of Chemical Ecology. 2022 Jan 31;48(3):323–36. doi: 10.1007/s10886-021-01324-4.