CAS: 656820-32-5; N6-Cyclohexyl-N2-(4-Morpholinophenyl)-9H-Purine-2,6-Diamine

上下游产品

N6-Cyclohexyl-2-Fluoroadenine 852231-88-0
2-Chloro-N-Cyclohexyl-9H-Purin-6-Amine 39639-45-7

📜2-氟-6-氯嘌呤置于n,N-二异丙基乙胺体系中,用 乙醇,正丁醇 作为反应溶剂,化学反应 36.0H,反应生成 N6-环己基-N2-(4-吗啉苯基)-9H-嘌呤-2,6-二胺
参考文献:Dedifferentiation Of Lineage-Committed Cells By A Small Molecule
标题:Dedifferentiation Of Lineage-Committed Cells By A Small Molecule
摘要:Combinatorial Libraries Were Screened For Molecules That Induce Mouse Myogenic Lineage Committed Cells To Dedifferentiate In Vitro. A 2,6-Disubstituted Purine,Reversine,Was Discovered That Induces Lineage Reversal Of C2C12 Cells To Become Multipotent Progenitor Cells Which Can Redifferentiate Into Osteoblasts And Adipocytes. This And Other Such Molecules Are Likely To Provide New Insights Into The Molecular Mechanisms That Control Cellular Dedifferentiation And May Ultimately Be Useful To In Vivo Stem Cell Biology And Therapy.
DOI:10.1021/ja037390K

专利信息

专利号:US-9023385-B2
优先权日:2011-06-01
标题 :Pharmaceutical use of 2-(4-morpholinoaniline)-6-cyclohexyl aminopurine and/or salt thereof for improving liver functioning
发明人：LEE KA HO KENNETH; CHEN RUOHAN; HOU ZHIBO; PAN QUANWEI
权利人:LEE KA HO KENNETH; CHEN RUOHAN; HOU ZHIBO; PAN QUANWEI; ZHANGZHOU PIEN TZE HUANG PHARM
摘要:A method of treating a patient to improve liver functioning includes providing a drug composed of at least one of pharmaceutical 2-(4-morpholinoaniline)-6-cyclohexyl aminopurine and a pharmaceutically acceptable salt thereof; and administering the drug to the patient in a manner and dosage effective to improve liver functioning. The 2-(4-morpholinoaniline)-6-cyclohexyl aminopurine can inhibit the activated hepatic stellate cells from synthesizing and expressing collagens and other extracellular matrix proteins including MMPs and TIMPs, and so it can inhibit liver fibrosis. In the liver, it can inhibit collagen synthesis and expression, and therefore reverse and treat hepatitis and liver cirrhosis effectively. Also discloses is a method for preparing drugs for treating infective hepatitis, non-infectious hepatitis, liver injury, liver cirrhosis, liver cancer and liver fibrosis, and improving t liver functioning, in which the compound and/or salt thereof is used optionally or in combination with a target molecule or carrier comprising a vitamin A-coupled liposome.

专利号:US-2023271983-A1
优先权日:2020-07-29
标题 :Functionalized isonitriles and products, preparation and uses thereof
发明人：SOTELO PÉREZ EDDY; AZUAJE GUERRERO JHONNY ALBERTO; MAJELLARO MARIA
权利人:UNIV SANTIAGO COMPOSTELA
摘要:The present invention relates to functionalized isonitrile compounds, formed by means of multicomponent environmentally friendly reactions, suitable for coupling to functional molecules such as biomolecules, APIs, chromophore and fluorophore molecules. The invention also relates to conjugates between said isonitrile compounds and functional molecules, which are useful in the synthesis of pharmaceutic drugs or tools, fluorescent molecules and labels, polymeric smart materials. The invention furthermore provides a kit for the in-vitro preparation of the functionalized isontrile compounds and conjugates. The invention also contemplates the medical use of said compounds and conjugates.

专利号:CN-119530189-A
优先权日:2024-11-22
标 题 :Recombinant omega-aminotransferase catalyst, encoding gene thereof and application of recombinant omega-aminotransferase catalyst in catalytic synthesis of cyclohexylamine