CAS: 6240-90-0; (R)-Heptan-2-Amine

相似化合物

34566-05-7 693-16-3 101689-06-9

欧盟法规

[ECHA物质

上下游产品

2-heptylamine 2-(2'-heptylamino)-2-phenylethanol methylamine ethyl 4-chloro-3-hydroxybutanoate (S)-(+)-2-benzylaminoheptane 2-heptylamine (R)-2-heptylamine

📜异庚胺置于(S)-ω-Transaminase,(R)-Amine Dehydrogenase体系中,用 二甲基亚砜 作为反应溶剂,化学反应 24.0H,以99%的收率获得产物
参考文献:外消旋胺通过ω-转氨酶和胺脱氢酶的生物催化级联反应脱去对映体纯的(R)-和(S)-胺
标题:外消旋胺通过ω-转氨酶和胺脱氢酶的生物催化级联反应脱去对映体纯的(R)-和(S)-胺
摘要:据报道,α-手性胺的一锅法除气策略包括对相应的酮进行对映选择性脱氨,然后通过对映体互补生物催化剂进行立体选择性胺化.值得注意的是,使用ω-转氨酶和胺脱氢酶的级联反应仅通过控制由它们催化的反应方向就可以访问(R)-和(S)-胺产物.获得了多种(R)和(S)胺,它们具有出色的转化率(> 80%)和对映体过量(> 99%ee).最后,制备规模的合成导致获得对映纯(R)‐和(S)‐13 分离产率分别为53%和75%.
DOI:10.1002/cctc.201900080

专利信息

专利号:US-8084630-B2
优先权日:2007-05-31
标 题 :Process for the synthesis of ramelteon and its intermediates
发明人：KANSAL VINOD KUMAR; MISTRY DHIRENKUMAR N; VASOYA SANJAY L; RAFILOVICH MICHAL; MOHA-LERMAN ELENA BEN; LIFSHITZ-LIRON REVITAL
权利人:KANSAL VINOD KUMAR; MISTRY DHIRENKUMAR N; VASOYA SANJAY L; RAFILOVICH MICHAL; MOHA-LERMAN ELENA BEN; LIFSHITZ-LIRON REVITAL; TEVA PHARMA
摘要:The present invention provides processes and intermediates for the synthesis of ramelteon.

专利号:US-2001047100-A1
优先权日:2000-04-26
标 题:Chiral imidazoyl intermediates for the synthesis of 2-(4-imidazoyl)-cyclopropyl derivatives
发明人：KJAERSGAARD HANS JOERGEN; PHILLIPS JIM; ALI SYED M
摘要:Novel intermediates useful in the preparation of optically active H 3 histamine receptor antagonist 2-(4-imidazoyl)-cyclopropyl derivatives are disclosed.

专利号:US-2009281176-A1
优先权日:2007-11-01
标题:Process for the synthesis of ramelteon and its intermediates
发明人：KANSAL VINOD KUMAR; MISTRY DHIRENKUMAR N; VASOYA SANJAY L; PATEL RAKESH; JADAV ARPAN M
权利人:KANSAL VINOD KUMAR; MISTRY DHIRENKUMAR N; VASOYA SANJAY L; PATEL RAKESH; JADAV ARPAN M
摘要:A process for the preparation of ramelteon and intermediates useful in the process. The process suitable for industrial scale provides increased yield and/or greater purity with fewer process steps.

专利号:US-9085511-B2
优先权日:2011-04-04
标题:Atropisomeric 1,8-bisphenolnapthalenes and their use in enantioselective recognition and asymmetric synthesis
发明人：WOLF CHRISTIAN; GHOSN MARWAN
权利人:WOLF CHRISTIAN; GHOSN MARWAN; UNIV GEORGETOWN
摘要:This invention related to atropisomeric 1,8-bisphenolnaphthalenes and derivatives thereof of the general formula (I): n nwhich are useful in resolution of enantiomers, enantioselective recognition and asymmetric synthesis.

专利号:WO-2009056993-A2
优先权日:2007-11-01
标题 :A process for the synthesis of ramelteon and its intermediates

专利号:US-2009069581-A1
优先权日:2007-05-31
标题:Process for the synthesis of ramelteon and its intermediates