CAS: 6123-63-3; 1-(5-Methyl-1-Phenyl-1H-Pyrazol-4-yl)Ethanone

该化合物是有机化合物,其特点是配有双氮原子的五人环形环状结构,由五人组成,含有两个氮原子,该化合物具有配有配有丙烯的氯酮功能组(乙酮),有助于其反应性及有机合成的潜在应用,甲基组和苯组的存在增强了其疏水特性,影响其在有机溶剂中的溶解性.通常,此类化合物可能表现出生物活动,使其对药用化学感兴趣.分子结构允许各种相互作用,包括氢结扎和欧元堆叠,这可能会影响其在不同环境中的行为.其合成往往涉及在受管制条件下的适当前体的反应,并可能用于开发药品或农用化学品.与许多有机化合物一样,处理和储存安全数据以及潜在环境影响.

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98700-50-6 5078-57-9 671181-66-1

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上下游产品

4-acetyl-5-methyl-1-phenylpyrazole phenylhydrazone ethoxylideneacetylacetone phenylhydrazine acetyl-5 dimethyl-2,4 pyrimidine 2-(5-Methyl-1-phenyl-1H-pyrazol-4-yl)-1-pyrrolidin-1-yl-ethanethione 1-(5-Methyl-1-phenyl-1H-pyrazol-4-yl)-2-pyrrolidin-1-yl-2-thioxo-ethanone 2-(5-Methyl-1-phenyl-1H-pyrazol-4-yl)-1-piperidin-1-yl-ethanethione 1-(5-Methyl-1-phenyl-1H-pyrazol-4-yl)-2-piperidin-1-yl-2-thioxo-ethanone

合成工艺路线路线简述

    📜3-O-Phenetidinomethylene-Pentane-2,4-Dione置于盐酸体系中,化学反应生成 4-乙酰基-5-甲基-1-苯基吡唑
    参考文献:Dains; Harger,Journal Of The American Chemical Society,1918,Vol. 40,P. 566
    标题:Dains; Harger,Journal Of The American Chemical Society,1918,Vol. 40,P. 566

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    专利信息


    专利号:US-6552018-B1
    优先权日:1997-01-27
    标 题:Pyrazole derivatives
    发明人：EJIMA AKIO; OHSUKI SATORU; OHKI HITOSHI; NAITO HIROYUKI
    权利人:DAIICHI SEIYAKU CO
    摘要:The present invention relates to cis- and trans-forms of pyrazole derivatives, salts thereof, or agents containing the same, and represented by the general formula (I): n wherein G represents a nitrogen containing saturated heterocyclic structure represented by the following formula: n These compounds exhibit anti-tumor activity on 5-FU-resistant tumors and effects on P glycoprotein expressing, multiple-drug resistant tumors. An example of a pyrazole derivative which demonstrates 50% inhibition of tumor cell growth is 3-[4-(3-chloro-5-fluorophenyl)- 1 piperazinyl]-1-[1-(3-chloro-2-pyridyl)-5-methyl-4-pyrazolyl)-1-trans-propene hydrochloride. Synthesis of the compounds represented by formula (I) can be prepared by any one of various routes such as a Mannich reaction, a Wittig reaction, reductive amination or substitution by allylation.

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    主要参考文献

    参考标题:2-Bromo-1-(1H-Pyrazol-4-Yl)Ethanone: Versatile Precursor For Novel Mono- And Bis[pyrazolylthiazoles]
    作者:Mostafa E. Salem,Ahmed F. Darweesh,Ahmed E. M. Mekky,Ahmad M. Farag,Ahmed H. M. Elwahy |发布日期:2017.1
    摘要:The Synthesis Of Novel Bis(Thiazoles) 20A, 20B, 20C And 23A, 23B, 23C Is Reported. Thus, Reaction Of 2‐bromo‐1‐(5‐methyl‐1‐phenyl‐1H‐pyrazol‐4‐yl)Ethanone (6) With The Corresponding Thioamide Derivatives 7A,7B, In Refluxing Etoh In The Presence Of Triethylamine, Afforded 4‐pyrazolylthiazoles 8A, 8B In Good Yields. On The Other Hand, The Novel Bis(Thiazoles) 20A, 20B, 20C And 23A, 23B, 23C Were Obtained

    合成参考文献


    摘要:Götzinger, A. C.; Müller, T. J. J., Science of Synthesis Knowledge Updates, (2017) 3, 117.
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