CAS: 58481-10-0; 2-Iodopyridine-4-Carboxylic Acid

相似化合物

134579-47-8 114821-24-8 1308677-83-9

上下游产品

CAS号6313-54-8 2-氯异烟酸

📜2-氯异烟酸置于氢碘酸,Sodium Iodide体系中,用 丁酮 作为反应溶剂,化学反应 6.0H,反应生成 2-碘吡啶-4-羧酸
参考文献:Ep1612204
标题:Ep1612204

专利信息

专利号:WO-2011110511-A1
优先权日:2010-03-11
标题:Spect imaging agents of amyloid plaques
发明人：SCHMITT-WILLICH HERIBERT; HEINRICH TOBIAS; BROCKSCHNIEDER DAMIAN
权利人:Bayer Pharma AG; SCHMITT-WILLICH HERIBERT; HEINRICH TOBIAS; BROCKSCHNIEDER DAMIAN
摘要:The invention relates to novel iodine -radiolabeled compounds useful for diagnosing Alzheimer's desease, to respective novel precursors for the synthesis of such compounds, and to the process of manufacturing said imaging agent of the following Formula (I), wherein Q is a six membered aromatic ring, either carbocycle or heterocycle with one N- atom, wherein X 1 , X 2 , X 3 , X 4 and X 5 are independently selected from N or C, and wherein zero or one of X 1 ( X 2 , X 3 , X 4 or X 5 is N and the remaining ones are C; A is either Sn(alkyl)3, I, l-123, l-124, l-125, l-131, Br; wherein alkyl comprises methyl, ethyl, propyl, butyl, pentyl and hexyl, Y is C or N; with the proviso that if X 1 ( X 2 , X 3 , X 4 or X 5 has the meaning of N, substitution by A in that position is excluded; or a pharmaceutically acceptable salt thereof.

专利号:WO-2011095593-A1
优先权日:2010-02-08
标 题 :Iodo precursor for a pet imaging agent of amyloid plaques
发明人：SCHMITT-WILLICH HERIBERT; HEINRICH TOBIAS; BROCKSCHNIEDER DAMIAN
权利人:BAYER SCHERING PHARMA AG; SCHMITT-WILLICH HERIBERT; HEINRICH TOBIAS; BROCKSCHNIEDER DAMIAN
摘要:The invention relates to a precursor for a [ 18 F]-labeled PET tracer for imaging of Alzheimer's Disease, its synthesis and the process for preparing the respective [ 18 F]-labeled PET tracer.