📜4-异丙基甲苯置于间氯过氧苯甲酸体系中,用 氯仿 作为反应溶剂,化学反应 3.0H,以20.8%的收率获得产物百里醌 参考文献:Efficient Preparation Of Some Biologically Active Substances From Natural And Nonnatural Aromatic Compounds By M-Chloroperbenzoic Acid Oxidation 标题:Efficient Preparation Of Some Biologically Active Substances From Natural And Nonnatural Aromatic Compounds By M-Chloroperbenzoic Acid Oxidation 摘要: DOI:10.1021/jo00258A010
专利号:US-12419872-B2 优先权日:2020-03-05 标 题:Low-temperature synthesis of thymoquinone and harmaline compounds 发明人:ZAID GENE H; WOLF BETH ANN; ROPP RACHEL ELIZABETH; DONAVALLI KRISHNA MOHAN; VERMA RAJNI 权利人:ANKH LIFE SCIENCES LTD 摘要:Low-temperature syntheses of thymoquinone/harmaline compounds which are useful for the treatment of human diabetes and cancers, and the derivatives, solvates, prodrugs, isomers, and tautomers of such compounds.
专利号:US-11358963-B2 优先权日:2020-03-05 标 题 :Low-temperature synthesis of thymoquinone and harmaline compounds 发明人:ZAID GENE H; WOLF BETH ANN; ROPP RACHEL ELIZABETH 权利人:ANKH LIFE SCIENCES LTD 摘要:Low-temperature syntheses of thymoquinone/harmaline compounds are provided which give increased yields of desirable products having molecular weights of from about 360-380. The syntheses involve carrying out reactions between thymoquinone and harmaline and a non-interfering solvent at a temperature of less than about 10° C.
专利号:US-11724244-B2 优先权日:2021-02-26 标题:Semiconductor chip devices and methods for polynucleotide synthesis 发明人:MERRIMAN BARRY; DE RIDDER RYAN; HOLDEN MATTHEW T; GEISER TIM 权利人:AVERY DIGITAL DATA INC 摘要:Systems and methods for polynucleotide synthesis utilize electrochemical deprotection and novel redox chemistries compatible with advanced CMOS nodes, for highly reliable and massively scalable parallel construction of polynucleotide segments having a desired sequence or sequences. Via use of these exemplary techniques, low-cost and large-scale polynucleotide synthesis is facilitated, for example for data storage and retrieval applications.
专利号:US-7674934-B2 优先权日:2004-08-05 标题:Stabilizers for use in NVP synthesis 发明人:HOEFER FRANK; BRAND ALEXANDRA; BOETTCHER ARND; BAUMANN KATRIN; VOGELSANG REGINA 权利人:BASF AG 摘要:A process for preparing N-alkenyl compounds by reacting the corresponding NH compounds with alkynes in the liquid phase in the presence of a catalyst, wherein the reaction is carried out in the presence of at least one stabilizer, and the use of stabilizers for increasing the selectivity in a process for preparing N-alkenyl compounds by reacting the corresponding NH compounds with alkynes in the liquid phase in the presence of a catalyst.
专利号:US-4459227-A 优先权日:1981-03-02 标 题:Para-hydroxyphenylhydrazines as in situ precursors of iminoquinones and quinones 发明人:SAHMEL REINHARDT O; GRAHAM DOYLE G 权利人:UNIV DUKE 摘要:Iminoquinone precursors having the formula wherein R1 represents hydrogen or an enzymatically hydrolyzable group; R2 and R3 independently represent hydrogen, a non-electron-withdrawing organic substituent or an enzymatically hydrolyzable group except that when R1 is hydrogen, R2 must be an enzymatically hydrolyzable group and R3 must not inhibit the hydrolysis of R2; R4 represents hydrogen or an electron-withdrawing or non-electron-withdrawing organic substituent, except that if R1 is hydrogen, R4 may not inhibit the hydrolysis of R2; W, X, Y and Z independently represent hydrogen or an electron-withdrawing or non-electron-withdrawing organic substituent, or any one of X and W, Y and Z, or X and R4 taken together represents a cyclic or heterocyclic ring having 5 to 6 ring atoms; and wherein said enzymatically hydrolyzable group is selected so that a hydrolysis product is biologically benign for the biological system in which said precursor is present is produced by hydrolysis of the hydrolyzable group. Also disclosed are methods of synthesis and methods of use of these compounds.
专利号:US-2022160685-A1 优先权日:2020-03-05 标题 :Low-temperature synthesis of thymoquinone and harmaline compounds
1: Karaca G, Aydin O, Pehlivanli F, Altunkaya C, Uzun H, Güler O. Effectiveness of thymoquinone, zeolite, and platelet-rich plasma in model of corrosive oesophagitis induced in rats. Ann Surg Treat Res. 2017 Jun;92(6):396-401. doi: 10.4174/astr.2017.92.6.396. Epub 2017 May 29. 2: Alobaedi OH, Talib WH, Basheti IA. Antitumor effect of thymoquinone combined with resveratrol on mice transplanted with breast cancer. Asian Pac J Trop Med. 2017 Apr;10(4):400-408. doi: 10.1016/j.apjtm.2017.03.026. Epub 2017 Apr 7. doi: 10.1016/j.pharep.2017.02.021. [Epub ahead of print] doi: 10.1186/s12906-017-1786-0. 6: Ebrahimi SS, Oryan S, Izadpanah E, Hassanzadeh K. Thymoquinone exerts neuroprotective effect in animal model of Parkinson's disease. Toxicol Lett. 2017 Jul 5;276:108-114. doi: 10.1016/j.toxlet.2017.05.018. Epub 2017 May 17. doi: 10.1016/j.pharep.2017.03.002. [Epub ahead of print] doi: 10.2174/1389202917666160803151752. Review.
合成参考文献
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