CAS: 462-43-1; 3-Fluoropropan-1-Ol

相似化合物

461-56-3 372-93-0 461-52-9

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CAS号627-30-5 3-氯-1-丙醇 | CAS号71742-12-6 1-(3-hydroxypro... | CAS号614-50-6 3-Fluoropropyl=... | CAS号504-63-2 1,3-丙二醇 | CAS号352-91-0 1-溴-3-氟丙烷 | CAS号461-56-3 3-氟丙酸 | CAS号462-40-8 3-氟-1-碘代丙烷 | CAS号312-68-5 3-氟丙基 4-甲基苯磺酸酯 | CAS号71-23-8 正丙醇 | CAS号372-04-3 3-氟甲烷磺酸丙酯 | CAS号77063-66-2 3-氟丙醛

((3-氟丙氧基)甲基)苯置于palladium 10% On Activated Carbon,氢气体系中,用 二氯甲烷 作为反应溶剂,化学反应 5.5H,反应生成 3-氟丙醇
参考文献:部分氟化的n-烷基取代的哌啶-2-羧酰胺对药理学性质的影响
标题:部分氟化的n-烷基取代的哌啶-2-羧酰胺对药理学性质的影响
摘要:通过选择性地将1-3个氟原子引入n-丙基和n中,研究了n-烷基-哌啶-2-羧酰胺的药理相关特性的调节局部麻醉药罗哌卡因和左旋布比卡因的叔丁基侧链.附近氟取代基对碱的调节本质上是加和的,并且表现出随氟与碱中心之间的拓扑距离而变的指数衰减.中性哌啶衍生物的固有亲脂性显示出对连接至中性杂芳基系统的部分氟化烷基的特征响应.但是,附近的氟取代基引起的碱度降低会影响中性ph值的亲脂性,因此所有部分氟化的衍生物的亲脂性都比其未氟化的母体相似或更高.发现水溶性与亲脂性成反比,并且与晶体堆积能有很大关系,如熔点温度的变化所示.发现所有氟化衍生物在人肝微粒体中都更容易被氧化,降解速率与亲脂性增加相关.因为哌啶-2-羧酰胺核心是手性的,所以与对映异构体配对n-烷基是非对映异构的.虽然对于碱性或亲脂性几乎观察不到对这种立体异构的反应,但是对于熔点温度和氧化降解观测到更明显的变化.
DOI:10.1002/cmdc.201600325

专利信息

专利号:US-2003162992-A1
优先权日:2001-12-14
标 题 :Preparation of intermediates useful in the synthesis of antiviral nucleosides
发明人：WATANABE KYOICHI A; DU JINFA
摘要:The present invention is an efficient process for the manufacture of α-acyloxyacetaldehyde, a key intermediate in the synthesis of 1,3-oxathiolane and 1,3-dioxolane nucleosides.

专利号:US-2013184465-A1
优先权日:2010-09-30
标 题:Process for the synthesis of thio-triazolo-group containing compounds
发明人：DOCHNAHL MAXIMILIAN; KEIL MICHAEL; GEBHARDT JOACHIM; VOGELBACHER UWE JOSEF; RACK MICHAEL
权利人:DOCHNAHL MAXIMILIAN; KEIL MICHAEL; GEBHARDT JOACHIM; VOGELBACHER UWE JOSEF; RACK MICHAEL; BASF SE
摘要:The present invention relates to a process using specific magnesium reagents for providing thio-triazolo group-containing compounds and for the synthesis of precursors therefor. The invention furthermore relates to intermediates and to their preparation.

专利号:US-2003232996-A1
优先权日:2001-04-20
标题:Regioselective synthesis of 3,4-di{(carboclyl or heterocyclyl)thiophenes
发明人：BROWN DAVID L; LUDWIG CINDY L
摘要:A novel process for preparing 3,4-di(carbocyclyl or heterocyclyl)thiophenes comprising reacting a compound of Formula IV with a ring cyclizing reagent to form the compound of Formula V to yield a compound of Formula V wherein R 1 , R 2 and R 3 are as defined in the specification.

专利号:WO-8911470-A1
优先权日:1988-05-27
标题 :Dihalogeno-3,3 fluoro-2 propenols-1, preparation method and utilization for the synthesis of fluoro-2 acrylic and dihalogeno-3,3 fluoro-2 acrylic acids and their derivatives
发明人：WAKSELMAN CLAUDE; NGUYEN THOAI; MOLINES HUGUETTE
权利人:CENTRE NAT RECH SCIENT
摘要:The invention relates to dihalogeno-3,3 fluoro-2 propenol-1 having the formula X?1X?2C=CF-CH2?OH (I), wherein X?1 and X?2, which may be identical or different, represent a fluorine, a chlorine or a bromine atom providing that X?1 and X?2 do not represent both a chlorine atom. These compounds may be prepared by reaction of an alcohol having the formula HCH?1X?2-CFX?3-CH2?OH (II), X?1 and X?2 have the meaning given hereabove and X?3 is a fluorine, chlorine or bromine atom, similar to or different from X?1 and/or X?2, with an organolithian compound. They may be used to prepare halides of the fluoro-2 acrylic acid and of the dihalogeno-3,3 fluoro-2 acrylic acids or their esters.

专利号:US-6600052-B1
优先权日:2000-04-25
标题:Regioselective synthesis of 3,4-di(carbocyclyl or heterocyclyl)thiophenes
发明人：BROWN DAVID L; LUDWIG CINDY L
权利人:PHARMACIA CORP
摘要:A novel process for preparing 3,4-di(carbocyclyl or heterocyclyl)thiophenes comprising reacting a compound of Formula IV:with a ring cyclizing reagent to form the compound of Formula V to yield a compound of Formula V:wherein R1, R2 and R3 are as defined in the specification.

专利号:US-7759497-B2
优先权日:2002-05-24
标 题:Synthesis of diaryl pyrazoles
发明人：LETENDRE LEO J; MCGHEE WILLIAM D; SNODDY CYNTHIA; KLEMM GEORGE; GAUD HENRY T
权利人:PFIZER
摘要:A process for the qualitative preparation of 3-haloalkyl-1H-pyrazoles suitable for efficient, high payload commercial application.