📜2,6-二硝基甲苯置于盐酸,Ammonium Sulfide,Tin(Ll) Chloride体系中,化学反应 0.0H,反应生成 3-氟-2-甲基苯胺 参考文献:Evidences For The Direct Field Effect. Ii.1 The Alkaline Rearrangement Of Fluorosubstituted α-Diketones2 标题:Evidences For The Direct Field Effect. Ii.1 The Alkaline Rearrangement Of Fluorosubstituted α-Diketones2 摘要: DOI:10.1021/ja01486A022
专利号:EP-3103803-B1 优先权日:2008-10-27 标 题 :Intermediates for the synthesis of mtor kinase inhibitors
专利号:US-5998595-A 优先权日:1996-11-05 标题:Azidohalogenobenzyl derivatives, sugar compounds and protection of hydroxy groups 发明人:KUSUMOTO SHOICHI; FUKASE KOICHI 权利人:WAKO PURE CHEM IND LTD 摘要:Azidohalogenobenzyl derivatives of the formula (I) ##STR1## wherein A is a halogen atom, B is a halogen atom or a hydrogen atom, and X is a group reactive with a hydroxy group, methods of protecting hydroxy group(s) using said derivatives, and sugar compounds wherein a hydrogen atom of at least one hydroxy group is substituted by an azidohalogenobenzyl group. According to the present invention, there are provided novel derivatives capable of introducing a group into a compound having hydroxy group(s), which group is useful as a stable hydroxy-protecting group even in solid phase synthesis for the purpose of the extension of sugar chain under continuous acidic conditions and of being removed under mild conditions; sugar compounds protected by using said derivatives; and methods of protecting hydroxy group(s) using said derivatives.
专利号:US-2023104311-A1 优先权日:2020-02-17 标题:Novel 6-substituted 7-deazapurines and corresponding nucleosides as medicaments 发明人:HERDEWIJN PIET; GROAZ ELISABETTA; QINGFENG LI 权利人:UNIV LEUVEN KATH 摘要:The present invention relates to the synthesis of 6-substituted 7-deazapurines and their corresponding nucleosides by coupling aryl or alkyl Grignard reagents with halogenated purine nucleosides in the presence of iron or an iron/copper mixture such as Fe(acac)3/CuI. The present invention also relates to pharmaceutical compositions comprising said compounds and the use of said pharmaceutical compositions to treat or prevent viral infections.
专利号:EP-3660020-A1 优先权日:2008-10-27 标题 :Process for the synthesis of mtor kinase inhibitors
专利号:BR-112016017679-B1 优先权日:2014-02-21 标题 :5-BENZYLISOQUINOLINE DERIVATIVE COMPOUNDS FOR THE TREATMENT OF CARDIOVASCULAR DISEASES, PROCESS FOR THE SYNTHESIS OF SUCH COMPOUNDS AND PHARMACEUTICAL COMPOSITION CONTAINING THEM
专利号:ES-2794012-T3 优先权日:2008-10-27 标题 :Intermediaries for the synthesis of mTOR kinase inhibitors
[参考文献]: I Achiwa, Et Al. Synthesis And Mutagenicity Of A New Mutagen, 2-Amino-1,7,9-Trimethylimidazo[4,5-G]Quinoxaline, And Its Analog. Chem Pharm Bull (Tokyo). 1994 Feb;42(2):408-9.
合成参考文献
摘要:Silva, V. L. M.; Pinto, D. C. G. A.; Santos, C. M. M.; Rocha, D. H. A., Science of Synthesis Knowledge Updates, (2022) 3, 300.