CAS: 443-86-7; 3-Fluoro-2-Methylaniline

该化合物是属于类类的有机化合物,是芳香胺,其特点是氟原子和亚麻碱苯环的甲基组,具体分别在3和2个位置上;该化合物一般无色至黄色液体或固体,取决于其纯度和温度;已知该化合物在水中的中等溶解度和有机溶解度良好,因此在各种化学反应和应用中有用;氟原子的存在可增强该化合物的再活动性并影响其物理特性,例如沸点和熔点;3-Fluoro-2-甲基碘因其功能组而经常用于染料,药品和农用化学品合成,因为其功能组可进一步进行化学修改;与许多一样,它可能构成健康风险,因此需要在实验室和工业环境中谨慎处理和采取适当的安全措施.

结构式图片

欧盟法规

ECHA物质ECHA物质C&L通报REACH预注册

上下游产品

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合成工艺路线路线简述

  • 合成目标产物 3-Fluoro-2-Methylaniline 主要起始原料 2-Methyl-3-Nitroaniline
  • (文献来源)合成步骤主要原料 2-Methyl-3-Nitroaniline
📜2,6-二硝基甲苯置于盐酸,Ammonium Sulfide,Tin(Ll) Chloride体系中,化学反应 0.0H,反应生成 3-氟-2-甲基苯胺
参考文献:Evidences For The Direct Field Effect. Ii.1 The Alkaline Rearrangement Of Fluorosubstituted α-Diketones2
标题:Evidences For The Direct Field Effect. Ii.1 The Alkaline Rearrangement Of Fluorosubstituted α-Diketones2
摘要:
DOI:10.1021/ja01486A022

海关参考信息

专利信息


专利号:EP-3103803-B1
优先权日:2008-10-27
标 题 :Intermediates for the synthesis of mtor kinase inhibitors

专利号:US-5998595-A
优先权日:1996-11-05
标题:Azidohalogenobenzyl derivatives, sugar compounds and protection of hydroxy groups
发明人:KUSUMOTO SHOICHI; FUKASE KOICHI
权利人:WAKO PURE CHEM IND LTD
摘要:Azidohalogenobenzyl derivatives of the formula (I) ##STR1## wherein A is a halogen atom, B is a halogen atom or a hydrogen atom, and X is a group reactive with a hydroxy group, methods of protecting hydroxy group(s) using said derivatives, and sugar compounds wherein a hydrogen atom of at least one hydroxy group is substituted by an azidohalogenobenzyl group. According to the present invention, there are provided novel derivatives capable of introducing a group into a compound having hydroxy group(s), which group is useful as a stable hydroxy-protecting group even in solid phase synthesis for the purpose of the extension of sugar chain under continuous acidic conditions and of being removed under mild conditions; sugar compounds protected by using said derivatives; and methods of protecting hydroxy group(s) using said derivatives.

专利号:US-2023104311-A1
优先权日:2020-02-17
标题:Novel 6-substituted 7-deazapurines and corresponding nucleosides as medicaments
发明人:HERDEWIJN PIET; GROAZ ELISABETTA; QINGFENG LI
权利人:UNIV LEUVEN KATH
摘要:The present invention relates to the synthesis of 6-substituted 7-deazapurines and their corresponding nucleosides by coupling aryl or alkyl Grignard reagents with halogenated purine nucleosides in the presence of iron or an iron/copper mixture such as Fe(acac)3/CuI. The present invention also relates to pharmaceutical compositions comprising said compounds and the use of said pharmaceutical compositions to treat or prevent viral infections.

专利号:EP-3660020-A1
优先权日:2008-10-27
标题 :Process for the synthesis of mtor kinase inhibitors

专利号:BR-112016017679-B1
优先权日:2014-02-21
标题 :5-BENZYLISOQUINOLINE DERIVATIVE COMPOUNDS FOR THE TREATMENT OF CARDIOVASCULAR DISEASES, PROCESS FOR THE SYNTHESIS OF SUCH COMPOUNDS AND PHARMACEUTICAL COMPOSITION CONTAINING THEM

专利号:ES-2794012-T3
优先权日:2008-10-27
标题 :Intermediaries for the synthesis of mTOR kinase inhibitors

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品牌试剂参考报价(招募中)

📌 第三方产品分析报告

✅ COA系统入驻 | 共享模式

主要参考文献

[参考文献]: I Achiwa, Et Al. Synthesis And Mutagenicity Of A New Mutagen, 2-Amino-1,7,9-Trimethylimidazo[4,5-G]Quinoxaline, And Its Analog. Chem Pharm Bull (Tokyo). 1994 Feb;42(2):408-9.

合成参考文献


摘要:Silva, V. L. M.; Pinto, D. C. G. A.; Santos, C. M. M.; Rocha, D. H. A., Science of Synthesis Knowledge Updates, (2022) 3, 300.
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