CAS: 367514-88-3; Lurasidonhydrochloride

上下游产品

CAS号14166-28-0 顺式-2,3-降冰片烷二羧酸酐 | CAS号14805-29-9 (3aR,4S,7R,7aS)... | CAS号173658-50-9 (1S,2S)-cyclohe... | CAS号3205-34-3 (1S,2S)-环己烷-1,2-二甲醇 | CAS号542-92-7 环戊二烯 | CAS号2746-19-2 顺-5-降冰片烯-外型-2,3-二甲酸酐 | CAS号186204-37-5 (3aR,7aR)-4'-(1...

((1R,2R)-Cyclohexane-1,2-Diyl)Dimethanol置于盐酸,水,四丁基硫酸氢铵,Potassium Carbonate,三乙胺体系中,用 二氯甲烷,水,N,N-二甲基甲酰胺,丙酮 作为反应溶剂,化学反应 6.5H,反应生成 盐酸鲁拉西酮
参考文献:一种盐酸鲁拉西酮的制备方法
标题:一种盐酸鲁拉西酮的制备方法
摘要:本发明公开了一种盐酸鲁拉西酮的制备方法,它是以trans-1,2-环己烷二甲酸(Sm-1)为原料经过拆分,甲酯化,还原,甲磺酰化,缩合,重结晶和成盐,最后得到盐酸鲁拉西酮.该方法大大降低了生产成本,具有产品收率高,易于操作,毒性低,适于工业化大规模生产的特点.

专利信息

专利号:US-9518047-B2
优先权日:2013-10-17
标题 :Process for the industrial synthesis of lurasidone
发明人：ANGELINI TOMMASO; BETTONI PIERGIORGIO; ROLETTO JACOPO; PAISSONI PAOLO
权利人:PROCOS SPA
摘要:Disclosed is a process for the industrial synthesis of Lurasidone from (1R,2R)-cyclohexane-1,2-diyldimethanol (1), 3-(piperazin-1-yl)benzo[d]isothiazole (3) and (3aR,4R,7R,7aS)-3a,4,7,7a-tetrahydro-4,7-methanoisobenzofuran-1,3-dione (6).). Said process is optimised to obtain Lurasidone with high yields and high purities by preparing highly pure synthesis intermediates, using critical raw materials and reagents in amounts close to the stoichiometric amounts, increasing productivity and reducing the costs and environmental impact of the process.

专利号:US-10196400-B2
优先权日:2015-01-08
标 题:Process for the preparation of lurasidone and its intermediate
发明人：GHARPURE MILIND; TIWARI SHASHI KANT; WAGH GANESH; REVANAPPA GALGE; WARPE MANIKRAO; ZALTE YOGESH; KRISHNMURTHY DHILEEPKUMAR
权利人:PIRAMAL ENTPR LTD
摘要:The present invention provides an improved process for preparation of the substantially pure (3aR,7aR)-4′-(benzo[d]isothiazol-3-yl)octahydrospiro[isoindole-2,1′-piperazin]-1′-ium methanesulfonate (referred to as compound-II), which is useful as a key intermediate for the synthesis of lurasidone ((3aR,4S,7R,7aS)-2-{(1R,2R)-2-[4-(1,2-benzisothiazol-3-yl)piperazin-1ylmethyl]cyclohexylmethyl}hexahydro-4,7-methano-2H-isoindole-1,3-dione). The process comprises reaction of the compound-III (as described herein) with the compound-IV (as described herein) in the presence of a solvent mixture selected from an alcohol and water; and a base The improved process for the preparation of compound II provides the product with total amount of unreacted compound-IV as impurity in less than 0.06% and the product with HPLC purity as ≥99.8%. The process further refers purification of Lurasidone hydrochloride, wherein the product contains the residual acetone <5000 ppm.

专利号:JP-2016533359-A
优先权日:2013-10-17
标题:Process of industrial synthesis of lurasidone

专利号:US-8853395-B2
优先权日:2013-02-22
标 题 :Process for the preparation of lurasidone hydrochloride
发明人：ZACCHE MATTEO; Gerli Fulvio; GATTI PIERANDREA
权利人:EDMOND PHARMA SRL
摘要:Disclosed is a new and efficient process for the synthesis with high yields and purity of lurasidone hydrochloride, a medicament which is useful as a psychotropic substance. The process involves the preparation of lurasidone base in a reaction system not containing inorganic salts, followed by conversion of the latter to an addition salt with an organic carboxylic acid, which is finally converted to lurasidone hydrochloride.

专利号:IT-MI20131737-A1
优先权日:2013-10-17
标 题 :PROCESS FOR THE INDUSTRIAL SYNTHESIS OF LURASIDONE

专利号:ES-2637744-T3
优先权日:2013-10-17
标题 :Process for the industrial synthesis of lurasidone