CAS: 302348-51-2; (4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-yl)Phenyl)Methanol

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CAS号76-09-5 频哪醇 | CAS号59016-93-2 4-(羟甲基)苯硼酸 | CAS号18282-51-4 4-碘苄醇 | CAS号73183-34-3 双戊酰二硼 | CAS号873-75-6 4-溴苄醇 | CAS号128376-64-7 4-甲酰基苯硼酸频哪醇酯 | CAS号1225050-00-9 2-[4'-(4'',4'',... | CAS号87199-17-5 4-甲酰基苯硼酸 | CAS号938043-30-2 4-(4-甲基-1-哌嗪甲基)... | CAS号884507-39-5 4-(吡咯烷-1基甲基)苯基硼酸频那醇酯 | CAS号859833-22-0 4-(哌啶甲基)苯硼酸频那醇酯 | CAS号1029439-56-2 N-(4-(4,4,5,5-四... | CAS号138500-85-3 4-溴甲基苯硼酸频哪酯 | CAS号138500-88-6 4-(氨甲基)苯基硼酸频哪醇酯 | CAS号138500-87-5 2-(4-(4,4,5,5-四... | CAS号18282-51-4 4-碘苄醇

📜2-[4'-(4'',4'',5'',5''-Tetramethyl-1'',3'',2''-Dioxaborolan-2''-yl)-Benzyloxy]Tetrahydrofuran置于aluminum (Iii) Chloride体系中,用 乙醇 作为反应溶剂,以67%的收率获得产物4-(羟甲基)苯硼酸频哪醇酯
参考文献:Caged Mitochondrial Uncouplers That Are Released In Response To Hydrogen Peroxide
标题:Caged Mitochondrial Uncouplers That Are Released In Response To Hydrogen Peroxide
摘要:Caged Versions Of The Most Common Mitochondrial Uncouplers (Proton Translocators) Have Been Prepared That Sense The Reactive Oxygen Species (Ros) Hydrogen Peroxide To Release The Uncouplers 2,4-Dinitrophenol (Dnp) And Carbonylcyanide P-Trifluoromethoxyphenylhydrazone (Fccp) From Caged States With Second Order Rate Constants Of 10 (+/-0.8) M(-1) S(-1) And 64.8 (+/-0.6) M(-1) S(-1),Respectively. The Trigger Mechanism Involves Conversion Of An Arylboronate Into A Phenol Followed By Fragmentation. Hydrogen Peroxide-Activated Uncouplers May Be Useful For Studying The Biological Process Of Ageing. (C) 2010 Elsevier Ltd. All Rights Reserved.
DOI:10.1016/j.Tet.2010.01.103

专利信息

专利号:US-9919064-B2
优先权日:2012-08-10
标 题 :Compositions, methods, and systems for the synthesis and use of imaging agents
发明人：CESATI RICHARD R; RADEKE HEIKE S; PANDEY SURESH K; PUROHIT AJAY; ROBINSON SIMON P
权利人:LANTHEUS MEDICAL IMAGING INC
摘要:The present invention provides compounds with imaging moieties for imaging a subject. The present invention also relates to systems, compositions, and methods for the synthesis and use of imaging agents, or precursors thereof. An imaging agent precursor may be converted to an imaging agent using the methods described herein. In some cases, a composition or plurality of imaging agents is enriched in 18 F. In some cases, an imaging agent may be used to image an area of interest in a subject, including, but not limited to, the heart, cardiovascular system, cardiac vessels, brain, and other organs.

专利号:US-9333264-B2
优先权日:2013-03-06
标 题:Biocompatible polymeric nanoparticles degrade and release cargo in response to biologically relevant levels of hydrogen peroxide
发明人：ALMUTAIRI ADAH; DE GRACIA LUX CAROLINE
权利人:UNIV CALIFORNIA
摘要:Disclosed are compositions and synthesis methods that pertain to biocompatible polymeric capsules capable of undergoing backbone degradation and cargo release upon exposure to biologically relevant concentrations of hydrogen peroxide (50-100 μM of H 2 O 2 ). In the invention, bio-responsive polyester bearing boronic ester triggers groups that degrade upon exposure to low concentrations of H 2 O 2 . The degradation is induced by transformation of a boronic ester to a phenol, which undergoes a quinone methide rearrangement to break down the polyester backbone.

专利号:US-9839642-B2
优先权日:2014-05-09
标 题:Beta-tetrazolyl-propionic acids as metallo-beta-lactamase inhibitors
发明人：TANG HAIFENG; YANG SHU-WEI; MANDAL MIHIR; SU JING; LI GUOQING; PAN WEIDONG; TANG HAIQUN; DEJESUS REYNALDA; PAN JIANPING; HAGMANN WILLIAM; DING FA-XIANG; XIAO LI; PASTERNAK ALEXANDER; HUANG YUHUA; DONG SHUZHI; YANG DEXI
权利人:MERCK SHARP & DOHME
摘要:The present invention relates to compounds of formula I that are metallo-β-lactamase inhibitors, the synthesis of such compounds, and the use of such compounds for use with β-lactam antibiotics for overcoming resistance.

专利号:US-11773130-B2
优先权日:2018-12-19
标 题 :3′ protected nucleotides
发明人：BERGMANN FRANK; CRISALLI PETER; HEINDL DIETER; KHAKSHOOR OMID; TAING MENG
权利人:ROCHE SEQUENCING SOLUTIONS INC
摘要:The present disclosure provides 3′ protected nucleotides, including those 3′ protected nucleotides having a detectable tag. Systems and methods of sequencing nucleic acids using the 3′ protected nucleotides are also disclosed, such as the sequencing of a nucleic acid using a nanopore or the sequencing of a nucleic acid via sequencing-by-synthesis.

专利号:US-2018318456-A1
优先权日:2012-08-10
标题:Compositions, methods, and systems for the synthesis and use of imaging agents

专利号:US-2020230264-A1
优先权日:2012-08-10
标 题 :Compositions, methods, and systems for the synthesis and use of imaging agents