CAS: 2623-86-1; 3-Bromobutanoic Acid

该化合物是一种卤化的碳酸,其特点是四碳丁酸链的第三碳中含有溴原子,其分子式为C4H7BRO2,其成分为碳酸性,其成分为碳酸性,其成分为碳酸性,其成分为碳酸性功能组(-COOH),该化合物一般是无色的,可粉黄黄色液体,有刺鼻味,在水和有机溶剂中溶解,可多种化学反应. 3-溴酸经常用作有机合成的中间体,特别是用于制备药,农用化学品和其他溴化化合物.溴的成分增加了其活性,使其能够参与核分裂替代反应.此外,它可以作为合成更复杂的分子的建筑块.在处理该物质时,应当采取安全防范措施,因为它可能会刺激皮肤和眼睛,并且应当保持适当的储存条件,以确保稳定性.

结构式图片

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7425-49-2 6089-12-9 1932379-45-7

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ECHA物质C&L通报REACH预注册

上下游产品

but-3-enoic acid crotononitrile (E)-but-2-enoic acid but-3-enenitrile methyl 3-bromopropionic acid methyl ester ethyl 3-bromobutanoate (E)-but-2-enoic acid 3-Brom-buttersaeure-trimethylsilylester

合成工艺路线路线简述

    📜反式-巴豆腈(含有约20的顺式同分异构体)置于氢溴酸体系中,化学反应生成3-溴丁酸
    参考文献:Brule,Bulletin De La Societe Chimique De France,1909,Vol. <4> 5,P. 1022
    标题:Brule,Bulletin De La Societe Chimique De France,1909,Vol. <4> 5,P. 1022

    海关参考信息

    专利信息


    专利号:US-8178712-B2
    优先权日:2006-06-23
    标 题:Process for the synthesis of Ibandronate sodium
    发明人:RAO DHARAMARAJ RAMCHANDRA; KANKAN RAJENDRA NARAYANRAO; GHAGARE MARUTI GANPATI
    权利人:RAO DHARAMARAJ RAMCHANDRA; KANKAN RAJENDRA NARAYANRAO; GHAGARE MARUTI GANPATI; CIPLA LTD
    摘要:The present invention relates to an improved process for the synthesis of Ibandronate sodium of formula (I). The present invention also provides novel processes for the synthesis of 3-[N-(methylpentyl)amino]propionic acid (III).

    专利号:US-2009143426-A1
    优先权日:2007-12-04
    标 题:Synthesis of 1,3,6-trisubstituted-2-carboxyquinol-4-ones as selective ET A antagonists and their use as medicaments
    发明人:STEPHANI RALPH ANTHONY; PATEL HARDIK JITENDRA; REZNIK SANDRA EVE; CANTOR JEROME OWEN
    权利人:STEPHANI RALPH ANTHONY; PATEL HARDIK JITENDRA; REZNIK SANDRA EVE; CANTOR JEROME OWEN
    摘要:The invention discloses the composition and preparation of various 1,3,6-trisubstituted-2-carboxy-quinol-4-ones of the formula 1 where R is H, alkyl, haloalkyl or hydroxyalkyl, R′ is alkyl, nitro, halogen or NR 2 ′″ where R′″ is alkyl or cycloalkyl, and R″ is H or alkyl. The composition of the invented compounds as methods of antagonizing the action of endothelin-1 to treat cardiovascular, pulmonary diseases and obstetric disorders and preterm labor and preeclampsia in mammals is disclosed.

    专利号:US-6262272-B1
    优先权日:1997-11-13
    标题 :Method of synthesis of pyrrole amides
    发明人:RAGAN JOHN ANTHONY; MAKOWSKI TERESA WOODALL; AM ENDE DAVID JON; CLIFFORD PAMELA JANE; YOUNG GREGORY RANDALL; CONRAD ALYSON KAY; EISENBEIS SHANE ALLEN; QUALLICH GEORGE JOSEPH; ALLEN DOUGLAS JOHN MELDRUM
    权利人:PFIZER
    摘要:A method for preparing pyrrole-carboxyamides which selectively bind to GABAa receptors; which comprises reacting 1,3-cycloakane-diones with bromoethylacetate followed by reaction of the resulting product with an acid halide followed by reaction with an aromatic amine and finally with an amonium source at an elevated temperature.

    专利号:US-2004220253-A1
    优先权日:2000-12-04
    标题 :Synthesis of pyrrole amides
    发明人:RAGAN JOHN A
    权利人:PFIZER
    摘要:A method for preparing particular pyrrole-carboxamides which selectively bind to GABAa receptors; which comprises reacting 1,3-cycloalkanediones with bromoethylacetate followed by reaction of the resulting product with an acid halide followed by reaction with an aromatic amine and finally with an amonium source at an elevated temperature.

    专利号:US-6005103-A
    优先权日:1993-11-19
    标题 :Pyrone derivatives as protease inhibitors and antiviral agents
    发明人:DOMAGALA JOHN MICHAEL; LUNNEY ELIZABETH; PARA KIMBERLY SUZANNE; PRASAD JOSYULA VENKATA NAGENDR; TAIT BRADLEY DEAN
    权利人:WARNER LAMBERT CO
    摘要:The present invention relates to novel tri- and tetrasubstituted pyrones and related structures which potently inhibit the HIV aspartyl protease blocking HIV infectivity. The pyrone derivatives are useful in the development of therapies for the treatment of bacterial and viral infections and diseases, including AIDS. The present invention is also directed to methods of synthesis of multifunctionalized pyrones and of related structures.

    专利号:WO-9925684-A1
    优先权日:1997-11-13
    标题 :Method of synthesis of pyrrole amides

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    📌 第三方产品分析报告

    ✅ COA系统入驻 | 共享模式

    主要参考文献

    [参考文献]: Y Morino, Et Al. Selective Inactivation Of Pyridoxamine Form Of Aspartate Aminotransferase By Iodoacetate. Carboxymethylation Of 4'-Amino Group Of Bound Pyridoxamine 5'-Phosphate. J Biol Chem. 1978 Sep 10;253(17):6026-30.

    合成参考文献


    摘要:Roy, K.-M., Science of Synthesis, (2007) 35, 370.
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