CAS: 19746-37-3; S-(Acetamidomethyl)-N-(Tert-Butoxycarbonyl)-L-Cysteine

相似化合物

86060-81-3 168300-88-7 16947-82-3

上下游产品

N-(tert-butyloxycarbonyl) azide S-acetamidomethyl-L-cysteine S-(acetamidomethyl)-L-cysteine hydr°Chloride tert-butyl dicarbonatedi-tert-butyl dicarbonateB°C-L-Cys(Acm)-OSu B°CCys(Acm)OPfp B°C-Cys(Acm)-D-Phe-Pro-OEt -O--S-(acetamidomethyl)-L-cysteinyl-L-valyl>-D-seryl>-N-methyl-L-alanine 2,2,2-Trichloroethyl Ester-O-(tert-butyloxy)carbonyl-S-(acetamidomethyl)-L-cysteinyl-L-valyl-D-seryl-N-methyl-L-alanine 2,2,2-Trichloroethyl Ester

N,N'-双(叔丁氧羰基)-L-胱氨酸置于盐酸,三氟乙酸,锌体系中,用 二氯甲烷,水,乙酸乙酯 用作溶剂,化学反应 8.0H,反应生成S-乙酰胺基甲基-N-叔丁氧羰基-L-半胱氨酸
参考文献:Flemer,Stevenson,Protein And Peptide Letters,2014,Vol. 21,# 12,P. 1257-1264
标题:Flemer,Stevenson,Protein And Peptide Letters,2014,Vol. 21,# 12,P. 1257-1264

专利信息

专利号:US-2007179279-A1
优先权日:2005-12-30
标题:Methods for the synthesis of arginine-containing peptides
发明人：CHEN LIN; ROBERTS CHRISTOPHER R
权利人:CHEN LIN; ROBERTS CHRISTOPHER R
摘要:Methods for the synthesis of arginine-containing peptides are provided. The methods include a step that minimizes contact of side chain protected arginine with base prior to the coupling step.

专利号:US-7038037-B2
优先权日:2002-06-20
标题 :Method for sequential support-bound synthesis of conjugated oligomeric compounds
发明人：MAIER MARTIN A; GUZAEV ANDREI P; MANOHARAN MUTHIAH
权利人:ISIS PHARMACEUTICALS INC
摘要:A sequential support-bound synthesis method is disclosed for preparing a conjugated oligomeric compound, preferably a PNA-peptide conjugate or an oligonucleotide-peptide conjugate, using a bridging molecule having at least two N-protecting amino groups. A conjugated oligomeric compound for therapeutic or prophylactic delivery is also disclosed.

专利号:US-7674881-B2
优先权日:2005-10-07
标题:Convergent synthesis of proteins by kinetically controlled ligation
发明人：KENT STEPHEN; PENTELUTE BRAD; BANG DUHEE; JOHNSON ERIK; DUREK THOMAS
权利人:UNIV CHICAGO
摘要:The present invention concerns methods and compositions for synthesizing a polypeptide using kinetically controlled reactions involving fragments of the polypeptide for a fully convergent process. In more specific embodiments, a ligation involves reacting a first peptide having a protected cysteyl group at its N-terminal and a phenylthioester at its C-terminal with a second peptide having a cysteine residue at its N-termini and a thioester at its C-termini to form a ligation product. Subsequent reactions may involve deprotecting the cysteyl group of the resulting ligation product and/or converting the thioester into a thiophenylester.

专利号:US-2004110228-A1
优先权日:2002-04-01
标 题:Combinatorial organic synthesis of unique biologically active compounds
发明人：MCALPINE SHELLI R; TAYLOR RACHEL E; BOLLA MEGAN L; SEGALL ANCA M
摘要:The invention provides a method for making a combinatorial library of cyclic compounds, such as Holliday junction-trapping compounds, comprising the steps of (a) obtaining a plurality of trimers according to the generic structure X 1- X 2- X 3 , wherein X 1 , X 2 and X 3 can be independently any naturally or nonnaturally occurring amino acids or peptidomimetics thereof; (b) optionally coupling a spacer S to the trimer at either end; (c) cyclizing two trimers or trimer-spacer conjugates in a head-to-tail orientation; thereby obtaining a combinatorial library of compounds, wherein the library does not include an unmodifed or naturally occurring Holliday Junction-trapping compounds. The invention additionally provides methods macrocyclic compounds that are synergimycin derivatives.

专利号:US-3560521-A
优先权日:1967-08-07
标题:Blocking groups for cysteine containing peptides
发明人：MILKOWSKI JOHN D; VEBER DANIEL F; HIRSCHMANN RALPH F
权利人:MERCK & CO INC
摘要:NOVEL PROTECTING GROUPS FOR PEPTIDES CONTAINING A CRYSTEINE RESIDUE. PROCESS FOR THE SYNTHESIS OF PEPTIDES CONTAINING A CYSTEINE RESIDUE WHEREIN THE MERCAPTO FUNCTION OF THE CYSTEINE RESIDUE IS PROTECTED BY A LABILE BLOCKING GROUP. NOVEL INTERMEDIATES USEFUL IN PEPTIDE SYNTHESIS.

专利号:US-3770822-A
优先权日:1967-08-07
标 题 :S-lower alkanoyl- and acetonyl-amino-methylcysteine
发明人：MILKOWSKI J; VEBER D; HIRSCHMANN R
权利人:MERCK & CO INC
摘要:NOVEL PROTECTING GROUPS FOR PEPTIDES CONTAINING A CYTEINE RESIDUE. PROCESS FOR THE SYNTHESIS OF PEPTIDES CONTAINING A CYSTEINE RESIDUE WHEREIN THE MERCAPTO FUNCTION OF THE CYSTEINE RESIDUE IS PROTECTED BY A LABILE BLOCKING GROUP. NOVEL INTERMEDIATES USEFUL IN PEPTIDE SYNTHESIS.