CAS: 184351-56-2; Potassium 2,3,3-Trimethyl-3H-Indole-5-Sulfonate

对氨基苯磺酸置于溶剂黄146,Potassium Hydroxide体系中,用 甲醇,异丙醇 用作溶剂,化学反应 6.0H,反应生成2,3,3-三甲基吲哚-5-磺酸钾盐
参考文献:一种季铵盐修饰的花菁类荧光染料及其合成方法和应用
标题:一种季铵盐修饰的花菁类荧光染料及其合成方法和应用
摘要:本发明公开了一种季铵盐修饰的花菁类荧光染料及其合成方法和应用.其中,一种季铵盐修饰的花菁类荧光染料,具有如下结构通式i: 在传统五甲川菁染料结构基础上引入磺酸基团和季铵盐修饰后得到的新结构染料,具有更好的水溶性.水溶性的提升避免了染料的自淬灭发生,增加了染料的实用性,使得该染料展示出较好的水溶性,生物相容性和较小的生物毒性.该染料具有近红外吸收和高荧光量子产率,可用于细胞成像,蛋白标记,抗体的特异性识别,核酸标记以及dna测序等方面的应用.

专利信息

专利号:US-8624035-B2
优先权日:2008-10-22
标题 :Functionalized cyanine having a silane linker arm, a method of preparing thereof and uses thereof
发明人：CAPUTO GIUSEPPE; MILETTO IVANA; BERTOLINO CHIARA ALESSANDRA; MARTRA GIANMARIO; COLUCCIA SALVATORE
权利人:CAPUTO GIUSEPPE; MILETTO IVANA; BERTOLINO CHIARA ALESSANDRA; MARTRA GIANMARIO; COLUCCIA SALVATORE; UNIV DEGLI STUDI TORINO
摘要:A silane-modified cyanine of Formula (I) includes the valence tautomers thereof: wherein R 1 is a linear, saturated or unsaturated alkyl chain, having 1 to 30 carbon atoms, wherein one or more carbon atoms are optionally substituted by a 4-, 5- or 6-membered aromatic or non aromatic cyclic grouping of carbon atoms; R 8 and R 9 are independently selected from the group consisting of —OCH 3 , —OCH 2 CH 3 , —OCH 2 CH 2 CH 3 , —OCH(CH 3 ) 2 , —OCH 2 CH 2 OCH 3 , —Cl, —Br, —I, Formula (II), Formula (III), —N(CH 3 ) 2 , Formula (IV), Formula (V), methyl, ethyl, propyl, isopropyl. The synthesis method and the use as a fluorescent marker are for inorganic solid supports, for example silica nanoparticles, and/or for biomolecules such as peptides, antibodies, DNA, RNA, etc.

专利号:US-7892297-B2
优先权日:2003-08-12
标题 :Cyanin-type compounds having an alkynyl linker arm
发明人：CAPUTO GIUSEPPE
权利人:CYANINE TECHNOLOGIES S P A
摘要:Cyanine-type fluorescent dyes modified with an alkynyl linker arm of formula (I), suitable for the conjugation of biomolecules, such as for example nucleosides, nucleotides, oligonucleotides, nucleic acids, proteins, peptides, vitamins and hormones. A method and intermediates for the synthesis of the alkynyl cyanines of the invention are also described, as well as alkynyl cyanine-biomolecule conjugates and methods for preparing thereof. The alkynyl cyanines can be advantageously used as markers for biomolecules or as quenchers.

专利号:US-8044203-B2
优先权日:2002-05-10
标 题 :Chiral indole intermediates and their fluorescent cyanine dyes containing functional groups
发明人：MUJUMDAR RATNAKER B; WEST RICHARD MARTIN
权利人:UNIV CARNEGIE MELLON; GE HEALTHCARE UK LTD
摘要:This invention relates to the functionalized cyanine dyes and more particularly, to the synthesis of chiral 3-substituted 2,3′-dimethyl-3H-indole and its derivatives as intermediates for preparation of cyanine dyes, to methods of preparing these dyes and the dyes so prepared.

专利号:US-9110069-B2
优先权日:2009-01-15
标题:Luminescent compounds
发明人：TERPETSCHNIG EWALD A; PATSENKER LEONID D; MARKOVA LARYSA; FEDYUNYAEVA IRYNA A; KOLOSOVA OLGA S; OBUKHOVA OLENA M; TATARETS ANATOLIY
权利人:SETA BIOMEDICALS LLC
摘要:Dyes and photoluminescent compounds based on polymethine dyes that contain at least one alkyl-phosphonate or substituted alkyl-phosphonate group, including the synthetic precursors, methods of synthesis, and applications thereof. Certain embodiments include heterocyclic ring systems and polymethine linkages selected such that the resulting polymethine dye is a cyanine dye, a merocyanine dye or a styryl dye.

专利号:CN-116239893-A
优先权日:2023-03-21
标 题 :A kind of cyanine fluorescent dye modified by quaternary ammonium salt and its synthesis method and application

专利号:CN-113248940-A
优先权日:2021-05-12
标 题:A kind of heptacyanine dye with high selective red light absorption and its synthesis method and application