CAS: 1476-53-5; Sodium 4-((7-(((2R,3R,4S,5R)-4-(Carbamoyloxy)-3-Hydroxy-5-Methoxy-6,6-Dimethyltetrahydro-2H-Pyran-2-yl)Oxy)-4-Hydroxy-8-Methyl-2-Oxo-2H-Chromen-3-yl)Carbamoyl)-2-(3-Methylbut-2-En-1-yl)Phenolate
该化合物是一种新生物素钠盐,一种来自新链球菌的氨基氨基氨基甲氨基甲氨基磺酰胺抗生素,它作为细菌DNA甘蓝酶(二至多异构体酶)的强大抑制剂,有效针对包括植物素科菌种在内的抗淋阳性细菌,其机制涉及对亚太酶亚单位的陀螺酶,干扰DNA复制.新生物素钠因其在研究应用中的效用而特别突出,例如研究抗生素抗体抗体机制和细菌对异构酶功能.复合物在水溶性中表现出高溶性,促进了体外研究,还被用于细菌隔离的选择性介质中.稳定和纯度对于可复制的实验结果至关重要.
- 英文名称Sodium 4-((7-(((2R,3R,4S,5R)-4-(Carbamoyloxy)-3-Hydroxy-5-Methoxy-6,6-Dimethyltetrahydro-2H-Pyran-2-yl)Oxy)-4-Hydroxy-8-Methyl-2-Oxo-2H-Chromen-3-yl)Carbamoyl)-2-(3-Methylbut-2-En-1-yl)Phenolate
- 中文名称新生霉素纳
- IUPAC名称sodium 4-((7-(((2R,3R,4S,5R)-4-(carbamoyloxy)-3-hydroxy-5-methoxy-6,6-dimethyltetrahydro-2H-pyran-2-yl)oxy)-4-hydroxy-8-methyl-2-oxo-2H-chromen-3-yl)carbamoyl)-2-(3-methylbut-2-en-1-yl)phenolate
- 其它别名4-[[7-(4-Carbamoyloxy-3-Hydroxy-5-Methoxy-6,6-Dimethyloxan-2-yl)Oxy-4-Hydroxy-8-Methyl-2-Oxochromen-3-Yl]Carbamoyl]-2
- CAS编号1476-53-5
- MFCD编号:MFCD00066541
- EINECS号:216-023-6
- FDA UNII编号:Q9S9NQ5YIY
- 分子式:C31H35N2NaO11分子量:634.61
- 产品CID: 706136
- 同类组份化合物CAS303-81-1 (free base)1476-53-5 (Na)4309-70-0 (Ca)
- 产品分类原料药 → 抗生素类药物 → 其它抗生素类药
物理性质
MSDS等安全信息
欧盟法规
C&L通报REACH预注册合成工艺路线路线简述
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
主要参考文献
1: Mandler MD, Baidin V, Lee J, Pahil KS, Owens TW, Kahne D. Novobiocin Enhances Polymyxin Activity by Stimulating Lipopolysaccharide Transport. J Am Chem Soc. 2018 Jun 6;140(22):6749-6753. doi: 10.1021/jacs.8b02283. Epub 2018 May 16.
2: May JM, Owens TW, Mandler MD, Simpson BW, Lazarus MB, Sherman DJ, Davis RM, Okuda S, Massefski W, Ruiz N, Kahne D. The Antibiotic Novobiocin Binds and Activates the ATPase That Powers Lipopolysaccharide Transport. J Am Chem Soc. 2017 Dec 6;139(48):17221-17224. doi: 10.1021/jacs.7b07736. Epub 2017 Nov 22.
3: Dlugosz A, Janecka A. Novobiocin Analogs as Potential Anticancer Agents. Mini Rev Med Chem. 2017;17(9):728-733. doi: 10.2174/1389557516666161223155525. Review. doi: 10.1111/mmi.13346. Epub 2016 Mar 16. doi: 10.1016/j.ejmech.2014.06.067. Epub 2014 Jun 28.
合成参考文献
摘要:Compound: Benzamide, N-[7-[[3-O-(aminocarbonyl)-6-deoxy-5-C-methyl-4-O-methyl-α-L-lyxo-hexopyranosyl]oxy]-4-hydroxy-8-methyl-2-oxo-2H-1-benzopyran-3-yl]-4-hydroxy-3-(3-methyl-2-buten-1-yl)-, sodium salt (1: )
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