CAS: 131543-23-2; (+)-Win 55212-2 Mesylate
该化合物是一家制药厂,主要以其作用为名,治疗勃起性机能障碍和肺动高血压;是一种硅酸盐,是一种五型磷酸酯(PDE5)选择性抑制剂;这种抑制导致循环guanosine 单磷酸酯(cGMP)水平的提高,导致血管传播和血液流改善; 盐可提高硅酸盐的溶性和生物利用率,使其更有效地用于治疗; 硅酸盐的特点是白色至非白晶状粉状,在水和有机溶剂中是溶液; 化合物经常通过口服,以相对快速的动作闻名而闻名; 其致癌性包括吸收,分配,主要在肝脏中的代谢和通过尿液排泄. 与任何药物一样,在开药或使用硅酸甲酸盐时,必须考虑潜在的副作用,反作用和与其他药物的相互作用.
- 英文名称(+)-Win 55212-2 Mesylate
- 中文名称WIN 55212-2 甲磺酸盐
- IUPAC名称[(3R)-2,3-dihydro-5-methyl-3-(4-morpholinylmethyl)pyrrolo[1,2,3-de]-1,4-benzoxazin-6-yl]-1-naphthalenyl-methanone, monomethanesulfonate
- 其它别名(R)-(+)-[2,3-DIHYDRO-5-METHYL-3-(4-MORPHOLINYLMETHYL)PYRROLO[1,2,3-DE]-1,4-BENZOXAZIN-6-YL]-1-NAPHTHALENYLMETHANONE MESYLATE; R(+)-[2,3-DIHYDRO-5-METHYL-3-[(MORPHOLINYL)METHYL]PYRROLO[1,2,3-DE]-1,4-BENZOXAZINYL]-(1-NAPHTHALENYL)METHANONE MESYLATE; (R)-(+)-(2,3-Dihydro-5-methyl-3-(4-morpholinylmethyl)pyrrolo[1.2.3-de]-1,4-benzoxazin-6-yl)-1-naphthalenylmethanonemesy
- CAS编号131543-23-2
- MFCD编号:MFCD00153882
- FDA UNII编号:2J851TP7VJ
- 分子式:C28H30N2O6S分子量:522.62
- 产品CID: 482290
- 同类组份化合物CAS131543-23-2 (mesylate)131543-22-1 (free base)
- 产品分类生物化工 → 生化试剂 → 激动剂抑制剂
- 相似结构搜索
- 产品信息参考
;;;; - InChIKey: FSGCSTPOPBJYSX-VEIFNGETSA-N
- FSGCSTPOPBJYSX-OZYVVJTJNA-N
- 计算化学: 氢键受体数7.0氢键供体数1.0可旋转键数4.0
物理性质
合成工艺路线路线简述
海关参考信息
- 2902902000-精萘
2905121000-正丙醇
2909110000-乙醚
2912110000-甲醛 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:US-2007287734-A1
优先权日:2006-06-09
标 题 :Preparation and utility of substituted pyrazole compounds with cannabinoid receptor activity
发明人：GANT THOMAS G; SARSHAR SEPEHR
权利人:AUSPEX PHARMACEUTICALS INC
摘要:The present disclosure is directed to modulators of CB-1 type receptors and pharmaceutically acceptable salts and prodrugs thereof, the chemical synthesis thereof, and the medical use of such compounds for the treatment and/or management of the severity and duration of obesity, metabolic syndrome, dyslipidemia, glucose imbalance, the inability to maintain weight loss, insulin resistance, a cardiovascular disorder, memory loss, drug dependence, a depressive disorder, a panic disorder, an obsessive-compulsive disorder, anxiety, post-traumatic stress syndrome, and any other condition in which it is beneficial to inhibit, inversely agonize or modulate a cannabinoid receptor are described.
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
主要参考文献
1: Rodríguez-Arias M, Roger-Sánchez C, Vilanova I, Revert N, Manzanedo C, Miñarro J, Aguilar MA. Effects of Cannabinoid Exposure during Adolescence on the Conditioned Rewarding Effects of WIN 55212-2 and Cocaine in Mice: Influence of the Novelty-Seeking Trait. Neural Plast. 2016;2016:6481862. doi: 10.1155/2016/6481862. Epub 2015 Dec 31.
2: Shabani M, Mahnam A, Sheibani V, Janahmadi M. Alterations in the intrinsic burst activity of Purkinje neurons in offspring maternally exposed to the CB1 cannabinoid agonist WIN 55212-2. J Membr Biol. 2014 Jan;247(1):63-72. doi: 10.1007/s00232-013-9612-1. Epub 2013 Nov 12. doi: 10.1016/j.exer.2013.02.009. Epub 2013 Feb 20.
5: Alonso-Alconada D, Alvarez A, Alvarez FJ, Martínez-Orgado JA, Hilario E. The cannabinoid WIN 55212-2 mitigates apoptosis and mitochondrial dysfunction after hypoxia ischemia. Neurochem Res. 2012 Jan;37(1):161-70. doi: 10.1007/s11064-011-0594-z. Epub 2011 Sep 11. doi: 10.1016/j.neulet.2010.10.067. Epub 2010 Nov 3.
合成参考文献
参考文献:10.1007/s002109900078
摘要:Akinshola BE, Taylor RE, Ogunseitan AB, Onaivi ES. Anandamide inhibition of recombinant AMPA receptor subunits in Xenopus oocytes is increased by forskolin and 8-bromo-cyclic AMP. Naunyn Schmiedebergs Arch Pharmacol. 1999 Sep;360(3):242–8. doi: 10.1007/s002109900078.
参考文献:10.1007/s00213-008-1190-z
摘要:Soderstrom K, Tian Q. CB(1) cannabinoid receptor activation dose dependently modulates neuronal activity within caudal but not rostral song control regions of adult zebra finch telencephalon. Psychopharmacology (Berl). 2008 Aug;199(2):265–73.
📝 需求与反馈
尽可能描述清楚需求与问题信息
