CAS: 70-25-7; 1-Methyl-3-Nitro-1-Nitrosoguanidine

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CAS号4245-76-5 甲基硝基胍 | CAS号143969-73-7 N'-nitroimidazo... | CAS号4245-76-5 甲基硝基胍 | CAS号18264-75-0 1-氨基-3-硝基胍 | CAS号2835-61-2 油溶棕3 | CAS号35089-66-8 2-(2-methylprop... | CAS号35089-71-5 2-hexyl-1-nitro... | CAS号35091-64-6 Guanidine,N-nit... | CAS号153088-76-7 Z-L-天冬氨酸β-叔丁酯溴甲基酮 | CAS号16807-60-6 3-甲氧基环己-2-烯-1-酮 | CAS号138090-35-4 N'-nitrotriazol...

📜1-甲基-3-硝基胍置于硝酸,Sodium Nitrite体系中,化学反应生成 1-甲基-3-硝基-1-亚硝基胍
参考文献:Mckay; Wright,Journal Of The American Chemical Society,1947,Vol. 69,P. 3029
标题:Mckay; Wright,Journal Of The American Chemical Society,1947,Vol. 69,P. 3029

专利信息

专利号:US-7635579-B2
优先权日:1999-08-02
标 题:Metabolic engineering of amino acid production
发明人：RAYAPATI P JOHN; CRAFTON COREY M
权利人:ARCHER DANIELS MIDLAND CO
摘要:The present invention is directed towards the fermentative production of amino acids, providing microorganisms, methods and processes useful therefor. Microorganisms of the invention are capable of converting glucose to amino acids other than L-isoleucine, L-leucine and L-valine with greater efficiency than the parent strain. The efficiency of conversion may be quantified by the formula: [(g amino acid produced/g dextrose consumed)*100]=% Yield and expressed as yield from dextrose. The invention provides microorganisms that are made auxotrophic or bradytrophic for the synthesis of one or more branched chain amino acids by mutagenesis and selected for their ability to produce higher percent yields of the desired amino acid than the parental strain. Preferred microorganisms are Corynebacterium, Brevibacterium or Escherichia coli producing L-lysine. Mutagenesis is performed by classical techniques or through rDNA methodology. Methods of the invention are designed to increase the production of an amino acid by mutagenizing a parental strain, selecting cells auxotrophic or bradytrophic for the synthesis of one or more branched chain amino acids and selecting branched chain amino acid auxotrophs or bradytrophs that produce a higher percent yield from dextrose of the desired amino acid than the parental strain. Processes of the invention are designed for the production an amino acid comprising culturing in a medium a microorganism obtained by mutagenizing a parent strain to be auxotrophic or bradytrophic for branched chain amino acid synthesis and selecting variants that are capable of converting glucose to amino acids other than L-isoleucine, L-leucine and L-valine with greater efficiency than the parent strain.

专利号:US-8637280-B2
优先权日:2005-12-01
标题:Genes useful for the industrial production of citric acid
发明人：BAUWELEERS HUGO MARC KAREL; GROESENEKEN DOMINIQUE ROBERT; PEIJ NOEL NICOLAAS MARIA ELISABETH VAN
权利人:BAUWELEERS HUGO MARC KAREL; GROESENEKEN DOMINIQUE ROBERT; PEIJ NOEL NICOLAAS MARIA ELISABETH VAN; ADCURAM NUTRITION HOLDING GMBH
摘要:The present invention relates to newly identified genes that encode proteins that are involved in the (bio)synthesis of citric acid. The invention also features polynucleotides comprising the full-length polynucleotide sequences of the novel genes and fragments thereof, the novel polypeptides encoded by the polynucleotides and fragments thereof, as well as their functional equivalents. The present invention also relates to the use of said polynucleotides and polypeptides as biotechnological tools in the production of citric acid from microorganisms, whereby a modification of said polynucleotides and/or encoded polypeptides has a direct or indirect impact on yield, production, and/or efficiency of production of the fermentation product in said microorganism. Also included are methods/processes of using the polynucleotides and modified polynucleotide sequences to transform host microorganisms. The invention also relates to genetically engineered microorganisms and their use for production of citric acid.

专利号:US-2009311760-A1
优先权日:2006-05-17
标题:Host cells and uses thereof in the microbial production of hydroxylated aromatics
发明人：WERY JAN; WESTERHOF REGINA GERDA MAAIKE; NIJKAMP KARIN
权利人:SCHOEMAKERSTRAAT 97
摘要:The invention relates to the field of the microbial production of substituted aromatics. In particular, it relates to the production of hydroxylated aromatics from renewable carbon stocks, like sugars or glycerol, via the metabolic intermediate L-tyrosine. Provided is a microbial host cell capable of producing at least one hydroxylated aromatic from a renewable carbon source, wherein at least one enzyme of said host cell that is involved in the degradation of said at least one hydroxylated aromatic is disabled and wherein the de novo synthesis of L-phenylalanine (L-Phe) in said host cell is impeded. Also provided is a method for the microbial production of at least one hydroxylated aromatic from a renewable carbon source, comprising culturing a host cell in the presence of exogenous L-Phe and a renewable carbon source and allowing said host cell to produce said at least one hydroxylated aromatic.

专利号:US-5912151-A
优先权日:1987-04-14
标题 :Preparation of xanthan gum
发明人：POLLOCK THOMAS J; THORNE LINDA
权利人:SHINETSU CHEMICAL CO; SHINETSU BIO INC
摘要:A method of increasing xanthan gum production, comprising culturing a Xanthomonas campestris strain having a xanthan-increasing modification in a culture medium, wherein the modification is selected from the group consisting of (1) a mutation causing rifampicin-resistance; (2) a mutation causing bacitracin-resistance; or (3) exogenous genetic information controlling the synthesis of xanthan; and separating xanthan from the culture medium, is provided along with specific DNA sequences and Xanthomonas campestris strains showing increased xanthan gum production.

专利号:US-2011318792-A1
优先权日:2006-08-15
标题 :Novel method for utilization of microbial mutant
发明人：OHSUGA TOSHIO; FUSHIKIDA KUNI
权利人:OHSUGA TOSHIO; FUSHIKIDA KUNI; ISHIHARA SANGYO KAISHA
摘要:The object of the present invention is to provide a microbial mutant capable of producing S-adenosylmethionine (hereinafter referred to as SAM) in a large amount with no change in growth characteristics and a method of efficiently producing SAM by incubating the microbial mutant. n The method of producing S-adenosylmethionine comprises incubating a microorganism having a loss or a reduction in the function of an enzyme relating to synthesis of phosphatidylcholine and recovering S-adenosylmethionine accumulated in the culture.

专利号:US-8124376-B2
优先权日:2002-07-26
标 题:Methods for producing biological substances in pigment-deficient mutants of bacillus cells
发明人：TANG MARIA; SLOMA ALAN; NAGGIAR LEGAL REPRESENTATIVE LESLIE; STERNBERG DAVID; STERNBERG LEGAL REPRESENTATIVE LINDA; BEHR REGINE
权利人:TANG MARIA; SLOMA ALAN; NAGGIAR LEGAL REPRESENTATIVE LESLIE; STERNBERG DAVID; STERNBERG LEGAL REPRESENTATIVE LINDA; BEHR REGINE; NOVOZYMES INC
摘要:The present invention relates to methods of producing a heterologous biological substance, comprising: (a) cultivating a mutant of a parent Bacillus cell under conditions conducive for the production of the heterologous biological substance, wherein (i) the mutant cell comprises a first nucleic acid sequence directing synthesis of the heterologous biological substance and a second nucleic acid sequence comprising a modification of at least one of the genes cypX and yvmC, which are involved in the production of a red pigment, and (ii) the mutant cell is deficient in the production of the red pigment compared to the parent Bacillus cell when cultivated under the same conditions; and (b) recovering the heterologous biological substance from the cultivation medium. The present invention also relates to mutants of Bacillus cells and methods for producing the mutants.