CAS: 6590-97-2; 2,3-Dichlorophenylisothiocyanate

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CAS号463-71-8 硫光气 | CAS号608-27-5 2,3-二氯苯胺 | CAS号41542-06-7 1-(2,3-二氯苯基)-2-硫脲

📜氯甲酸乙酯置于三乙胺体系中,化学反应生成 2,3-二氯苯基硫代异氰酸酯
参考文献:Compounds With Copper-Or Zinc-Activated Toxicity Against Microbial Infection
标题:Compounds With Copper-Or Zinc-Activated Toxicity Against Microbial Infection
摘要:具有新型吡唑硫酰胺基nnsn结构基元的杂环化合物,对微生物感染具有高效的锌或铜活化毒性,在微摩尔或纳摩尔最小抑制浓度(mic)下,以及制备和使用这些化合物的方法.

专利信息

专利号:US-6136984-A
优先权日:1996-04-22
标 题 :Solid phase and combinatorial synthesis of substituted thiophenes and of arrays of substituted thiophenes
发明人：DOERWALD FLORENCIO ZARAGOZA
权利人:NOVO NORDISK AS
摘要:A solid phase method for the synthesis of a plurality of differently substituted thiophenes with a wide variety of side-chain substituents as compounds of potential therapeutic interest is disclosed. The thiophenes are prepared by acylation of a substrate-bound primary or secondary amine with cyanoacetic acid and reaction of the resulting cyanoacetamide with an isothiocyanate in the presence of a base. Alkylation with an appropriate alkyl halide, followed by Thorpe-Ziegier-cyclization yields differently substituted, support-bound 3-aminothiophenes. These may be screened on the substrate or cleaved from the substrate and then screened in solution. Alternatively, the resin-bound 3-amino thiophenes or the synthetic intermediates can be subjected to further synthetic transformations (N-acylation, reduction) on the support, which permits the preparation of further therapeutically interesting compounds. The efficient synthesis of a wide variety of thiophenes using automated synthesis technology of the present method makes these compounds attractive candidates for the generation and rapid screening of diverse thiophene-based libraries. The method disclosed here provides an easy and fast access to highly diverse heterocyclic compounds of therapeutic interest, amenable to automatization.

专利号:WO-9700244-A1
优先权日:1995-06-19
标题 :Process for parallel synthesis of a non-peptide library
发明人：FRITZ JAMES E; KALDOR STEPHEN W
权利人:LILLY CO ELI; FRITZ JAMES E; KALDOR STEPHEN W
摘要:A process for the sequential preparation of a library of compounds having pharmaceutical usage. The process involves the sequential mixing of solution phase reagents, followed by scavenging of excess unreacted reagents with solid phase scavenging agents. The process is highly iterative and applicable for producing various ureas, thiureas, amides, carbonates and tertiary amines.

专利号:WO-9740034-A1
优先权日:1996-04-22
标题:Solid phase and combinatorial synthesis of substituted thiophenes and of arrays of substituted thiophenes

专利号:EP-1021435-A1
优先权日:1996-04-22
标题:Solid phase and combinatorial synthesis of substituted thiophenes and of arrays of substituted thiophenes

专利号:EP-1776367-A1
优先权日:2004-07-27
标题 :Synthesis of 6,7-dihydro-5h-imidazoý1,2-a¨imidazole-3-sulfonic acid amides

专利号:WO-2006014828-A1
优先权日:2004-07-27
标题 :Synthesis of 6,7-dihydro-5h-imidazo[1,2-a]imidazole-3-sulfonic acid amides