CAS: 4597-87-9; 2-(Methylamino)Pyridine

相似化合物

38427-94-0 45715-13-7 6935-27-9

上下游产品

CAS号89026-79-9 6-溴-2-甲氨基吡啶 | CAS号694-59-7 吡啶-N-氧化物 | CAS号74-89-5 氨基甲烷 | CAS号17624-36-1 2-pyridyllithium | CAS号436161-79-4 N-甲基-N-(吡啶-2-基)... | CAS号109-09-1 2-氯吡啶 | CAS号504-29-0 2-氨基吡啶 | CAS号64-18-6 甲酸 | CAS号82-38-2 1-(甲氨基)蒽醌 | CAS号84539-30-0 5-溴-2-(甲基氨基)吡啶 | CAS号5683-33-0 2-二甲氨基吡啶 | CAS号67242-59-5 N -甲基-N -(2-吡啶基)甲酰胺 | CAS号100868-76-6 N-甲基-N-(吡啶-2-基)甲烷磺酰胺 | CAS号1121-60-4 吡啶-2-甲醛 | CAS号1539-42-0 2,2'-二吡啶甲基胺 | CAS号16219-98-0 N-methyl-N-pyri... | CAS号161694-66-2 Carbamodithioic...

N-(2-吡啶基)甲酰胺置于盐酸,Sodium Hydride体系中,用 水,N,N-二甲基甲酰胺 作为反应溶剂,化学反应生成 2-(甲氨基)吡啶
参考文献:中离子吡啶并[1,2-A]嘧啶酮:一类抑制烟碱型乙酰胆碱受体的杀虫剂.
标题:中离子吡啶并[1,2-A]嘧啶酮:一类抑制烟碱型乙酰胆碱受体的杀虫剂.
摘要:已发现一类新型的中离子吡啶并[1,2-A]嘧啶酮类,具有优异的杀虫活性,可控制许多昆虫,特别是半翅目和鳞翅目.作用模式研究表明,它们主要作为抑制剂作用于烟碱乙酰胆碱受体(nachrs).在这里,我们报告这类化学的发现,演化和制备.还介绍了我们在结构-活性关系阐明和生物活性评估方面所做的努力.
DOI:10.1016/j.Bmcl.2016.10.031

专利信息

专利号:US-8735586-B2
优先权日:2007-06-26
标 题 :Regioselective copper catalyzed synthesis of benzimidazoles and azabenzimidazoles
发明人：ALONSO JORGE; LINDENSCHMIDT ANDREAS; NAZARÉ MARC; URMANN MATTHIAS; HALLAND NIS; RKYEK OMAR
权利人:ALONSO JORGE; LINDENSCHMIDT ANDREAS; NAZARÉ MARC; URMANN MATTHIAS; HALLAND NIS; RKYEK OMAR; SANOFI SA
摘要:The present invention relates to a process for the regioselective synthesis of compounds of the formula I, n nwherein R0; R1; R2; R3; R4; R5; A1; A2; A3; A4, Q and J have the meanings indicated in the claims. The present invention provides a direct copper catalyzed regioselective process to a wide variety of unsymmetrical, multifunctional N-substituted benzimidazoles or azabenzimidazoles of formula I starting from 2-halo-nitroarenes and N-substituted amides.

专利号:EP-2173747-B1
优先权日:2007-06-26
标 题:A regioselective metal catalyzed synthesis of annelated benzimidazoles and azabenzimidazoles
发明人：ALONSO JORGE; LINDENSCHMIDT ANDREAS; NAZARE MARC; R KYEN OMAR; URMANN MATHIAS; HALLAND NIS
权利人:SANOFI SA
摘要:The present invention relates to a process for the regioselective synthesis of compounds of the formula I, wherein R1; R2; R3; R4; J1; J2; J3; J4 and G have the meanings indicated in the claims. The present invention provides a direct metal, e.g. palladium or copper, catalyzed, regioselective process to a wide variety of unsymmetrical, multifunctional N-substituted benzimidazoles or azabenzimidazoles of formula I starting from 2-halo-nitroarenes and N-substituted amides.

专利号:WO-2019073011-A1
优先权日:2017-10-12
标题:ENZYMATIC SYNTHESIS OF LIPOLANTHIPEPTIDES
发明人：JUNGMANN NATALIA; MAINZ ANDI; WIEBACH VINCENT; SÃœSSMUTH RODERICH
权利人:DEINOVE SA
摘要:The present invention relates to methods of producing lipolanthipeptide compounds and in particular to the enzymatic activities involved in the synthesis of these compounds.

专利号:US-9221821-B2
优先权日:2012-06-05
标题:Methods for the synthesis of 1,3-substituted aminouracils and other xanthine-related compounds
发明人：DIEP NHUT; KALYAN YURIY B
权利人:FOREST LAB HOLDINGS LTD; FOREST LAB HOLDINGS LTD
摘要:Methods for the synthesis of disubstituted aminouracils and xanthine and/or xanthine-related compounds are provided.

专利号:US-12410131-B2
优先权日:2021-10-21
标题:Method for preparation of trans-n-benzyloxycarbonyl-(3-hydroxy-2-piperidinyl)-2-propanone as intermediate of halofuginone
发明人：FENG YU; XU HONG; WU JIAXUAN; SONG DANHUI; ZHONG WEIHUI; LING FEI; XU CHAO
权利人:CHENGDA PHARMACEUTICALS CO LTD
摘要:The present disclosure relates to the field of drug synthesis, and discloses a method for the preparation of trans-N-benzyloxycarbonyl-(3-hydroxy-2-piperidinyl)-2-propanone as an intermediate of halofuginone. In the preparation method according to the present disclosure, for the first time, trans-N-benzyloxycarbonyl-(3-hydroxy-2-piperidinyl)-2-propanone as shown in Formula I is obtained from amino-substituted pentanal and a thiazolyl sulfoxide compound as raw materials by Mislow-Evans rearrangement reaction and subsequent Lewis acid catalysis. The method for the preparation of trans-N-benzyloxycarbonyl-(3-hydroxy-2-piperidinyl)-2-propanone as an intermediate of halofuginone according to the present disclosure has high yields and stable qualities, provides a new reference route for the synthesis of trans-N-benzyloxycarbonyl-(3-hydroxy-2-piperidinyl)-2-propanone, avoids the reduction of pyridine, and overcomes the disadvantage of requiring the use of an expensive metal catalyst Rh/Al2O3.

专利号:EP-0389197-A1
优先权日:1989-03-20
标 题:Recovery of difluoro sugar
发明人：NAGARAJAN RAMAKRISHNAN
权利人:LILLY CO ELI
摘要:A process for recycling the difluoro sugar in the synthesis of 2,2-difluoronucleosides proceeds by removing the base moiety from α-difluoronucleosides by reduction and hydrolysis, followed by oxidation to put the difluoro sugar in a form conveniently recycled into the synthesis, and intermediates useful therefor.