CAS: 433-98-7; 2-Nitrobenzene-1-Sulfonyl Fluoride
该化合物是一种有机化合物,其特点是存在一个硝基化合物和附于苯环的全氟辛基磺酰氟功能组,该化合物一般是黄色的,以其反应性为名,特别是由于氟化磺组体的致命性,在核循环替代反应中尤为如此.该化合物经常被用作有机合成的试剂,特别是用于制备磺酰胺和其他磺酰氟衍生物.该硝基化合物有助于该化合物的电子抽取特性,增强其再活动性.此外,二硝基苯基氟化物在极有机溶剂中溶解,可适用于各种化学用途.然而,由于该化合物具有潜在的毒性,而且在与活性氟化合物打交道时需要采取适当的安全措施,因此应谨慎地加以处理.
物理性质
MSDS等安全信息
欧盟法规
ECHA物质C&L通报REACH预注册上下游产品
CAS号1694-92-4 邻硝基苯磺酰氯 | CAS号15898-45-0 Sodium o-nitrob...合成工艺路线路线简述
📜2-硝基苯磺酰胺置于potassium Fluoride,Pyrilium Tetrafluoroborate,Magnesium Chloride体系中,用 乙腈 作为反应溶剂,化学反应 2.0H,以59%的收率获得产物2-硝基苯磺酰氯
参考文献:从磺酰胺合成磺酰氟
标题:从磺酰胺合成磺酰氟
摘要:报道了一种从磺酰胺中简单实用地合成磺酰氟的方法.该方法利用 Pyry-Bf4 和 Mgcl2 反应形成磺酰氯,随后在 Kf 的存在下原位转化为更稳健和稳定的磺酰氟.该协议的温和条件和高化学选择性使磺酰氟从密集功能化分子的后期形成成为可能.由于其在化学生物学领域的成功活动,在其结构中带有磺酰氟的复杂有机分子的合成获得了巨大的动力.由于其独特的化学性质,几种磺酰氟已被用作化学生物学中的弹头,以靶向氨基酸残基并充当基于活性的探针(图 1).图1.功能化芳基磺酰氟作为活性探针的例子.文献中提供了多种磺酰氟的合成方法,从无数不同的起始材料开始.早期的合成可以从磺酰肼,硫代磺酸盐,磺酰氯,磺酸,磺酸盐等中找到(图 2A).然而,这些传统方法中的大多数在官能团兼容性方面受到限制,并且需要合成步骤才能获得起始材料.在最近的方法中,Willis,Bagley 和 Ball 独立解决了这些问题,并报告了使用简
DOI:10.1002/ejoc.202000022
专利信息
专利号:US-8034908-B2
优先权日:2003-02-14
标 题:Glycolipids and synthetic method thereof as well as their synthetic intermediates, and synthetic method thereof
发明人：ANNOURA HIROKAZU; MURATA KENJI; YAMAMURA TAKASHI
权利人:JAPAN GOVERNMENT
摘要:Novel glycolipid derivatives, where the substituent of the sphingosine base part is a short carbon chain alkyl group, substituted or unsubstituted cycloalkyl group, substituted or unsubstituted aryl group or substituted or unsubstituted aralkyl group and efficient synthetic methods for practical mass production of the same and intermediates useful for the synthesis of these compounds. n Glycolipids having the formula (I): n nwhere R 3 indicates a substituted or unsubstituted C 1 to C 7 linear alkyl group, substituted or unsubstituted cycloalkyl group, substituted or unsubstituted aryl group, or substituted or unsubstituted aralkyl group and R 8 indicates a substituted or unsubstituted C 1 to C 35 alkyl group, substituted or unsubstituted aryl group or substituted or unsubstituted aralkyl group are chemically synthesized.
专利号:EP-1619199-B1
优先权日:2003-02-14
标 题:Glycolipid derivatives, process for production of the same, intermediates for synthesis thereof, and process for production of the intermediates
专利号:US-2006074235-A1
优先权日:2003-02-14
标 题:Glycolipids derivatives, process for production of the same, intermediates for synthesis thereof, and process for production of the intermediates
专利号:EP-2343306-B1
优先权日:2003-02-14
标题:Glycolipid derivatives, process for production of the same, intermediates for synthesis thereof, and process for production of the intermediates
专利号:AU-2004210784-A1
优先权日:2003-02-14
标 题 :Glycolipid derivatives, process for production of the same, intermediates for synthesis thereof, and process for production of the intermediates
专利号:EP-2343306-A1
优先权日:2003-02-14
标 题:Glycolipid derivatives, process for production of the same, intermediates for synthesis thereof, and process for production of the intermediates
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
主要参考文献
参考标题:Metal‐free Visible‐light Synthesis Of Arylsulfonyl Fluorides: Scope And Mechanism作者:Dan Louvel,Aida Chelagha,Jean Rouillon,Pierre‐adrien Payard,Lhoussain Khrouz,Cyrille Monnereau,Anis Tlili |发布日期:2021.6.16
摘要:The First Metal-Free Procedure For The Synthesis Of Arylsulfonyl Fluorides Is Reported. Under Organo-Photoredox Conditions, Aryl Diazonium Salts React With A Readily Available So2 Source (Dabso) To Afford The Desired Product Through Simple Nucleophilic Fluorination. The Reaction Tolerates The Presence Of Both Electron-Rich And -Poor Aryls And Demonstrated A Broad Functional Group Tolerance. To Shed
合成参考文献
参考文献:10.1007/978-3-030-29430-4_8
摘要:Vogt N, Vogt J. Molecules with Six Carbon Atoms. 2019. In: Structure Data of Free Polyatomic Molecules.
📝 需求与反馈
尽可能描述清楚需求与问题信息
