CAS: 42248-31-7; 6-Chloro-4-Oxo-4H-Chromene-3-Carbaldehyde

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CAS号1450-74-4 2-羟基-5-氯苯乙酮 | CAS号68-12-2 N,N-二甲基甲酰胺 | CAS号1163120-28-2 6-chloro-3-(1-h... | CAS号876-27-7 乙酸-4-氯苯酯 | CAS号106-48-9 对氯苯酚 | CAS号861296-77-7 3-(5-chloro-2-h... | CAS号33533-99-2 6-氯色酮 | CAS号50743-20-9 6-氯色酮-3-腈 | CAS号68100-95-8 4-(5-CHLORO-2-H... | CAS号88021-73-2 6-chloro-3-(1,3... | CAS号88021-78-7 1-(5-chloro-2-h... | CAS号80031-01-2 1-(5-chloro-2-h... | CAS号918306-97-5 6-(5-chloro-2-h... | CAS号42059-70-1 (2E)-3-(6-chlor... | CAS号1263273-24-0 5-hydroxy-9-chl...

📜乙酸-4-氯苯酯置于aluminum (Iii) Chloride,三氯氧磷体系中,化学反应生成 6-氯-3-甲酰基色酮
参考文献:3-Formylchromone Based Topoisomerase Iiα Inhibitors: Discovery Of Potent Leads
标题:3-Formylchromone Based Topoisomerase Iiα Inhibitors: Discovery Of Potent Leads
摘要:取代的3-甲醛吡喃酮被合成并评价为人类dna拓扑异构酶iiα(htopo-Iiα)酶的抑制剂.脱连环,松弛和dna嵌插实验的结果显示,这些化合物(11B,12A,12B,12D,12E,13A和13B)对htopo-Iiα酶显示出强大的抑制活性,并且是非嵌插剂.这些化合物还表现出显著的体外细胞毒性(lc50范围为0.5至8.6 μm),对前列腺(pc-3)癌细胞系的毒性可与标准药物依托泊苷相比.为了进一步探究3-甲醛吡喃酮衍生物的可能作用机制,还进行了分子对接研究,结果显示,所研究的化合物很好地适应htopo-Iiα酶的atp结合口袋,具有非常好的对接分数,并与催化位点的关键残基形成非键相互作用.
DOI:10.1039/c3Md00125C

专利信息

专利号:WO-0053313-A2
优先权日:1999-03-09
标 题:Lanthanide catalysts for synthesis of compounds and combinatorial libraries

专利号:US-3984441-A
优先权日:1971-06-21
标 题:Chromonealdehyde compounds and process for the production thereof
发明人：NOHARA AKIRA; UMETANI TOMONOBU; MIYATA YOSHIBUMI; SANNO YASUSHI
权利人:TAKEDA CHEMICAL INDUSTRIES LTD
摘要:There are provided compounds of the general formula ##SPC1## n Wherein R is a hydroxy, alkyl, acyloxy, halogen, nitro, substituted or unsubstituted amino, alkoxy, carboxy or a group derived from a carboxy group and m is 0, 1 or 2 except where m is 2, the two R groups are both hydroxy groups. n The present invention is also concerned with a process for preparing the chromonealdehyde compounds. The chromonealdehyde compounds are characterized by antiallergic properties and are therefore useful as prophylactic and therapeutic agents for allergic asthma, allergic dermatitis and other allergic diseases and also are valuable as intermediates for the synthesis of other pharmaceutical compounds having the chromone nucleus.

专利号:US-2012316192-A1
优先权日:2011-06-09
标题:Substituted indolo [2,3-a] quinolizines
发明人：WALDMANN HERBERT; KUMAR KAMAL; HUEBEL KATJA; PRIES VERENA; DUECKERT HEIKO; MENNINGER SASCHA; ZIEGLER SLAVA; BRUSS HANNA; KHEDKAR VIVEK; ESCHENBRENNER VINCENT
权利人:WALDMANN HERBERT; KUMAR KAMAL; HUEBEL KATJA; PRIES VERENA; DUECKERT HEIKO; MENNINGER SASCHA; ZIEGLER SLAVA; BRUSS HANNA; KHEDKAR VIVEK; ESCHENBRENNER VINCENT
摘要:The present invention relates to novel substituted indolo[2,3-a]quinolizines and stereoisomeric forms thereof and/or pharmaceutically acceptable salts of these compounds as well as pharmaceutical compositions containing at least one of these substituted indolo[2,3-a]quinolizines together with pharmaceutically acceptable carrier, excipient and/or diluents. Said novel substituted indolo[2,3-a]quinolizines have been identified as useful for the prophylaxis and treatment of cancer by the induction of strong mitotic delays, chromosomal misalignments and mitotic tri- and multipolarization leading to cell cycle stop and apoptosis. Furthermore a synthesis for preparation of the substituted indolo[2,3-a]quinolizines is disclosed in the present invention.

专利号:CN-115819431-B
优先权日:2022-11-04
标题:Synthesis method and application of benzopyrone-fused hydroindole compounds