CAS: 4068-76-2; Methyl 5-Bromo-2-Hydroxybenzoate

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CAS号67-56-1 甲醇 | CAS号89-55-4 5-溴水杨酸 | CAS号119-36-8 水杨酸甲酯 | CAS号69-72-7 水杨酸 | CAS号7726-95-6 溴素 | CAS号39635-10-4 5-溴-2-羟基苯并肼 | CAS号18071-51-7 5-溴-2-羟基-3-碘苯羧酸甲酯 | CAS号91983-31-2 5-溴-2-羟基-3-硝基苯甲酸甲酯 | CAS号35354-74-6 和厚朴酚 | CAS号84437-12-7 5-氰基-2-羟基苯甲酸甲酯 | CAS号89-55-4 5-溴水杨酸 | CAS号7120-41-4 5-溴-2-甲氧基苯甲酸甲酯 | CAS号56341-31-2 2-溴-9h-占吨醇-9-酮 | CAS号141761-85-5 6-溴-3-氧代-3,4-二氢... | CAS号141761-82-2 3-氨基-5-溴-2-羟基苯甲酸甲酯

水杨酸甲酯置于1,4-Dioxane Dibromide体系中,化学反应 0.5H,以85%的收率获得产物5-溴水杨酸甲酯
参考文献:无溶剂条件下二恶烷二溴化物的区域选择性芳香亲电溴化
标题:无溶剂条件下二恶烷二溴化物的区域选择性芳香亲电溴化
摘要:摘要 在无溶剂条件下使用二恶烷二溴化物 (Dd) 以高产率和高纯度实现了芳香族化合物的高区域选择性环溴化.该方法的显着特点包括操作简单,反应快速,对溴化程度的出色控制以及反应过程中各种官能团的耐受性.
DOI:10.1080/00397910601055081

专利信息

专利号:US-8952042-B2
优先权日:2009-08-19
标 题 :FXR (NR1H4) binding and activity modulating compounds
发明人：KREMOSER CLAUS; ABEL ULRICH; STEENECK CHRISTOPH; KINZEL OLAF
权利人:KREMOSER CLAUS; ABEL ULRICH; STEENECK CHRISTOPH; KINZEL OLAF; PHENEX PHARMACEUTICALS AG
摘要:The present invention relates to compounds of formula (1): n nwhere R, A, Q and Z are defined herein, or an enantiomer, diastereomer, tautomer, solvate, prodrug or pharmaceutical acceptable salt thereof. These compounds bind to the NR1H4 receptor (FXR) and act as agonists of the NR1H4 receptor (FXR). The invention further relates to the use of the compounds for the preparation of a medicament for the treatment of diseases and/or conditions through binding of said nuclear receptor by said compounds, and to a process for the synthesis of said compounds.

专利号:CN-103864735-A
优先权日:2012-12-07
标 题:Synthesis of a novel 5-bromo-3(2H)-benzofuranone derivative and its application as an antitumor drug

专利号:US-8178559-B2
优先权日:2004-12-30
标 题:Organic compounds
发明人：BREITENSTEIN WERNER; EHARA TAKERU; EHRHARDT CLAUS; GROSCHE PHILIPP; HITOMI YUKO; IWAKI YUKI; KANAZAWA TAKANORI; KONISHI KAZUHIDE; MAIBAUM JUERGEN KLAUS; MASUYA KEIICHI; IWASAKI ATSUKO; OSTERMANN NILS; SUZUKI MASAKI; TOYAO ATSUSHI; YOKOKAWA FUMIAKI
权利人:BREITENSTEIN WERNER; EHARA TAKERU; EHRHARDT CLAUS; GROSCHE PHILIPP; HITOMI YUKO; IWAKI YUKI; KANAZAWA TAKANORI; KONISHI KAZUHIDE; MAIBAUM JUERGEN KLAUS; MASUYA KEIICHI; IWASAKI ATSUKO; OSTERMANN NILS; SUZUKI MASAKI; TOYAO ATSUSHI; YOKOKAWA FUMIAKI; NOVARTIS AG
摘要:3,4-substituted piperidine compounds, these compounds for use in the diagnostic and therapeutic treatment of a warm-blooded animal, especially for the treatment of a disease (=disorder) that depends on activity of renin; the use of a compound of that class for the preparation of a pharmaceutical formulation for the treatment of a disease that depends on activity of renin; the use of a compound of that class in the treatment of a disease that depends on activity of renin; pharmaceutical formulations comprising a 3,4-substituted piperidine compound, and/or a method of treatment comprising administering a 3,4substituted piperidine compound, a method for the manufacture of a 3,4-substituted piperidine compound, and novel intermediates and partial steps for their synthesis are disclosed. The 3,4-disubstituted piperidine compounds have the formula (I), wherein the symbols have the meanings defined in the specification.

专利号:US-9856241-B2
优先权日:2013-07-03
标 题:Substituted benzofuranyl and benzoxazolyl compounds and uses thereof
发明人：BALOGLU ERKAN; SHACHAM SHARON; SENAPEDIS WILLIAM; MCCAULEY DILARA; LANDESMAN YOSEF; GOLAN GALI; KALID ORI; SHECHTER SHARON
权利人:KARYOPHARM THERAPEUTICS INC
摘要:The invention generally relates to substituted benzofuranyl and substituted benzoxazolyl compounds, and more particularly to a compound represented by Structural Formula (A): or a pharmaceutically acceptable salt thereof, wherein the variables are as defined and described herein. The invention also includes the synthesis and use of a compound of Structural Formula (A), or a pharmaceutically acceptable salt or composition thereof, e.g., in the treatment of cancer (e.g., mantle cell lymphoma), and other diseases and disorders.

专利号:CN-119490422-A
优先权日:2023-08-15
标 题:Synthesis method of 2-fluoro-3-aminobenzoic acid and ester compound thereof