CAS: 356-42-3; 2,2,3,3,3-Pentafluoropropanoyl 2,2,3,3,3-Pentafluoropropanoate

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CAS号422-59-3 五氟丙酰氯 | CAS号422-64-0 五氟丙酸 | CAS号59239-87-1 bis(trifluorome... | CAS号422-64-0 五氟丙酸 | CAS号356-45-6 bis(pentafluoro... | CAS号141334-26-1 2,2,3,3,3-penta... | CAS号2002-94-0 3-(五氟苯基)丙酸 | CAS号71735-32-5 1-(五氟丙酰基)咪唑 | CAS号345901-60-2 2,2,3,3,3-penta... | CAS号718-66-1 2,2,3,3,3-penta... | CAS号755-76-0 2,2,3,3,3-penta... | CAS号80242-51-9 2,2,3,3,3-penta... | CAS号891-87-2 2,5-bis(1,1,2,2...

五氟丙酸置于phosphorus Pentoxide体系中,用80%的收率获得产物五氟丙酸酐
参考文献:吲哚的亲电取代.的部分环化18. ñ-Acyltryptamines
标题:吲哚的亲电取代.的部分环化18. ñ-Acyltryptamines
摘要:用三氟乙酸酐或五氟丙酸酐将n B-乙酰色胺8环化,可得到几乎定量的14和15型螺环二氢吲哚.反应的机制涉及通过环化本位在吲哚核的3-位-Attack,以形成螺环3 ħ-Indoles 12和13,其随后经历添加酸酐与的3 1,2-双键h-吲哚.通过转化3 H-吲哚-3-螺环戊烷16已确定了后者反应的一般性.和亚苄基苯胺18分别加入到酸酐加合物17A和19中.螺环二氢吲哚加合物14A,14B,15A,15B和17A被稀氨水迅速水解成羟基螺环二氢吲哚20A,20B,21A,21B和17B.
DOI:10.1039/p19920000461

专利信息

专利号:US-12435086-B2
优先权日:2020-04-29
标题:Synthesis of heterocyclic compounds
发明人：LIN JACK; WALTERS JASON
权利人:PLEXXIKON INC
摘要:Provided herein are intermediates and processes useful for facile synthesis of compounds of Formula 2:wherein R1 is C(O)R2; R2 is alkyl optionally substituted with 1-5 halogens; G is phenyl or a 5-6 membered heteroaryl optionally substituted with 1-2 R3; and each R3 is independently C1-C6 alkyl, CN, C1-C6 alkyl-CN, 3-6 membered cycloalkyl, or 4-6 membered heterocycloalkyl.

专利号:US-7592448-B2
优先权日:2003-02-28
标题:Mono amine and diamine derivatives of CL-20
发明人：GOLDING PETER; MACCUISH ALISTAIR J; BELLAMY ANTHONY JOHN
权利人:SECR DEFENCE BRIT
摘要:The invention describes the synthesis of novel mono-amine and di-amine derivatives of hexa-nitro-hexaazaisohexawurtzitane (CL-20). The synthesis is affected by the novel use of fluoroacylating compounds to protect the secondary amine groups of acylated precursors to CL-20 against nitrolysis. In so doing the mono-amine and di-amine derivatives of CL-20 are rendered and which in turn may be subsequently utilized as intermediates to generate further novel derivatives with differing physical and chemical properties to the parent compound. Formula (I), wherein: —Xâ•?H, and Yâ•?H or NO 2 .

专利号:US-2023357257-A1
优先权日:2020-12-28
标 题 :Novel process for the synthesis of noroxymorphone from morphine
发明人：GORBACHEV DMITRY; LAM HON WAI; SAXENA AAKARSH; SAXENA NAVIN SATYAPAL
权利人:NAVIN SAXENA RESEARCH & TECH PVT LTD
摘要:The present invention relates to a novel, efficient, pot- and atom-economical, and industrially applicable process for converting morphine to noroxymorphone using reagents and solvents of lesser toxicity and lower cost with respect to those used in the prior art.

专利号:US-4255594-A
优先权日:1979-09-18
标题 :Hydrogenation of halogen-containing carboxylic anhydrides
发明人：NOVOTNY MIROSLAV
权利人:ALLIED CHEM
摘要:A process is described for the heterogeneous hydrogenation of haloalkyl, halocycloalkyl or haloaryl carboxylic anhydrides to the corresponding primary alcohols. In the haloalkyl or halocycloalkyl carboxylic anhydrides at least one halogen is in the alpha-position relative to the carboxylic anhydride grouping. The hydrogenation can be carried out in the liquid or vapor phase in the presence of a supported or unsupported catalyst comprising a member of the group consisting of rhodium, iridium, metal oxides thereof, or mixtures thereof. In the liquid phase, the hydrogenation can be carried out batchwise under mild conditions of temperature and pressure, preferably at about 50°-150° C. and about 5-15 atmospheres, in an atmosphere containing hydrogen gas. A preferred embodiment is the hydrogenation of trifluoroacetic anhydride in the liquid phase to 2,2,2-trifluoroethanol, said alcohol being useful as an intermediate in the synthesis of the anesthetic, isoflurane, CF 3 CHClOCHF 2 .

专利号:US-7105637-B2
优先权日:2002-02-15
标题 :Dehydro-estriol (8-DHE3) and dehydro-pregnanetriol (7-DHPT), methods of their synthesis
发明人：SHACKLETON CEDRIC; GUO LI-WEI; WILSON WILLIAM K
权利人:CHILDRENS HOSP & RES CT OAK
摘要:The invention provides isolated dehydro-estriol (8-DHE 3 ) and dehydro-pregnanetriol (7-DHPT), and methods of their synthesis. These compounds are useful in diagnosis of Smith-Lemli-Optiz syndrome (SLOS).

专利号:US-12187735-B2
优先权日:2018-09-17
标 题:Matter of composition, synthesis, formulation and application of FL118 platform positions 7 and 9-derived analogues for treatment of human disease
发明人：LING XIANG; LI QINGYONG; LI FENGZHI
权利人:CANGET BIOTEKPHARMA LLC
摘要:Described herein, are the chemical synthesis, matter of compositions, formulation, function, methods and uses of the FL118 platform Positions 7 and/or 9-derived analogues for treating cancer or other human diseases. Compounds derived from chemical modifications of the FL118 platform are employed alone or in combination with other anti-cancer agents to preclude, eliminate or reverse cancer phenotypes. This invention intends to realize unique personalized cancer treatment (personalized precision medicine) through application of a series of structural relevant individual FL118 platform-derived analogues, which target multiple cellular human disease-relevant proteins and their signaling pathways.