CAS: 300-38-9; H-Tyr(3,5-Dibr)-Oh

上下游产品

CAS号60-18-4 L-酪氨酸 | CAS号7726-95-6 溴素 | CAS号64-19-7 冰醋酸 | CAS号105189-44-4 3,5-二溴酪氨酸三氟乙酰胺甲酯 | CAS号17194-82-0 对羟基苯乙酰胺 | CAS号58960-71-7 叔丁氧羰基-3,5-二溴-L-酪氨酸 | CAS号556-02-5 D-酪氨酸 | CAS号537-24-6 3,5-DIBROMOTYROSINE

📜L-酪氨酸置于bromoisocyanuric Acid Monosodium Salt,硫酸体系中,化学反应 1.5H,以71%的收率获得3,5-二溴-L-酪氨酸
参考文献:水溶液中未保护氨基酸的化学性质:在强酸性条件下,用溴异氰尿酸钠盐直接溴化芳香族氨基酸.
标题:水溶液中未保护氨基酸的化学性质:在强酸性条件下,用溴异氰尿酸钠盐直接溴化芳香族氨基酸.
摘要:在60%的水溶液中,用溴异氰尿酸单钠盐(bica-Na)溴化未保护的芳香族氨基酸,例如苯丙氨酸,酪氨酸和甘氨酸.H(2)so(4)在0摄氏度下以高收率得到单溴化产物的混合物.出乎意料的是,获得了间溴苯甘氨酸作为主要产物,同时伴随有邻位和对位取代的产物,而苯丙氨酸仅给出了邻位和对位取代的产物.2-苯基乙胺或苄胺的溴化显示出与相应氨基酸相似的趋势.
Doi:10.1248/cpb.54.1715

专利信息

专利号:US-4242256-A
优先权日:1977-03-15
标 题 :Synthesis of peptide analogues
发明人：SHARPE ROBERT; SZELKE MICHAEL
权利人:SHARPE ROBERT; SZELKE MICHAEL
摘要:Compounds being analogues of a dipeptide in which the nitrogen atom of the linking amide group of the dipeptide is replaced by trivalent group ##STR1## and in which, optionally, the carbonyl function of this linking group is replaced by the divalent group --CH 2 -- are of value in the synthesis of isosterically modified peptides.

专利号:US-10087221-B2
优先权日:2013-03-21
标题 :Synthesis of hydantoin containing peptide products
发明人：HENKEL BERND
权利人:SANOFI AVENTIS DEUTSCHLAND
摘要:The present invention relates to a method of synthesizing a peptide product comprising at least one hydantoin group. The peptide product may be used as a reference material for the quality control of pharmaceutical peptides, particularly for the quality control of exendin peptides. Further, the invention relates to hydantoin building blocks, a method for manufacturing such building blocks and their use for the synthesis of peptide products.

专利号:US-7452701-B2
优先权日:1998-11-24
标 题:Methods for the preparation of β-amino acids
发明人：FREY PERRY A; RUZICKA FRANK J
权利人:WISCONSIN ALUMNI RES FOUND
摘要:Purified β-amino acids are of considerable interest in the preparation of pharmacologically active compounds and industrial precursors. Although enantiomerically pure β-amino acids can be produced by standard chemical synthesis, this traditional approach is time consuming, requires expensive starting materials, and results in a racemic mixture which must be purified further. However, DNA molecules encoding lysine 2,3-aminomutase can be used to prepare β-amino acids by methods that avoid the pitfalls of chemical synthesis. The present invention provides a method of producing enantiomerically pure β-amino acids from α-amino acids comprising catalyzing the conversion of an α-amino acid to a corresponding β-amino acid by utilizing a lysine 2,3-aminomutase as the catalyst.

专利号:US-6482921-B1
优先权日:1999-01-28
标题:Uridyl peptide antibiotic (UPA) derivatives, their synthesis and use
发明人：BOOJAMRA CONSTANTINE G; LEMOINE REMY C; HECKER SCOTT; LEE VING J; LEGER ROGER
权利人:ESSENTIAL THERAPEUTICS INC
摘要:The present invention relates to dihydro derivatives of the uridyl peptide antibiotics mureidomycin, pacidimycin and napsamycin which have antibiotic activity against a number of bacterial strains including strains resistant to current therapeutic antibiotics.

专利号:US-3957760-A
优先权日:1970-12-16
标 题:Amino acid derivatives
发明人：BODANSZKY MIKLOS
权利人:SQUIBB & SONS INC
摘要:New lactone intermediates useful in the synthesis of peptides are prepared by reacting an α-amino acid with an active carbonyl compound which forms a Schiff's base. The latter is treated with a condensing agent so that cyclization occurs and a lactone is formed from which a peptide may be produced by reaction with an amino acid ester and removal of the protecting groups.

专利号:US-4960881-A
优先权日:1984-02-16
标 题 :α-chlorinated carbonates, their method of manufacture and application in the protection of the amine functions of amino acids
发明人：BARCELO GERARD; SENET JEAN-PIERRE; SENNYEY GERARD
权利人:POUDRES & EXPLOSIFS STE NALE
摘要:The invention relates to carbonates of formula: ##STR1## in which X is a fluorine, chlorine or bromine atom and R 1 is different from the ##STR2## group and represents: a substituted or non-substituted, saturated or unsaturated, aliphatic, araliphatic, primary, secondary, tertiary or cycloaliphatic radical. These α-chlorinated carbonates are prepared by the action of a compound of formula R 1 OH on a chloroformate of formula: ##STR3## in a solvent medium in the presence of an acid scavenger which is added after the two preceding compounds. They are used to block the amine function of amino acids. The α-chlorinated carbonate and amino acid are reacted in a solvent medium at a temperature of -5° to 100° C. in the presence of an acid scavenger. Blocked amines are very useful in peptide synthesis.