专利号:US-6121487-A 优先权日:1998-07-28 标题 :Method of producing amino acids and amino-acid derivatives 发明人:VOGT ANNEGRET; ALTENBACH HANS-JOSEF; KIRSCHBAUM MICHAEL; HAHN MICHAEL-GOTTFRIED; MATTHAUS MIKE SIEGFRIED PAUL; HERMANN ANDREAS RAINER 权利人:DEGUSSA 摘要:The present invention is relative to a chemical method of producing compounds of the general formula (I) starting from compounds of the general formula (II) and (III) under radical conditions. Products I are used as intermediates in the synthesis of bioactive substances.
专利号:US-2012267111-A1 优先权日:2009-12-30 标题 :Synthesis of Degradable Polymers Downhole for Oilfield Applications 发明人:KHLESTKIN VADIM KAMIL EVICH 权利人:KHLESTKIN VADIM KAMIL EVICH 摘要:A method is given for polymerizing monomers downhole to create well treatment polymers. The monomers each contain two polymerizable groups and a degradable group or groups which allow the polymer to degrade under downhole conditions, for example by hydrolysis. Polymerization downhole allows easier, more precise, placement of polymer. Polymer obtained from monomers pumped downhole may be used, for example, for fluid diversion plugs, isolation plugs, formation consolidation, flowback control, and fluid loss control. Synthesized polymer may form gels, films, solids or other structure in treated wellbores, fractures, and/or formations. After the desired effect is achieved, the deposited polymer degrades and the polymer degradation products dissolve, leaving the wellbore, fracture and/or formation clean, with no damage that might have decreased fluid flow.
专利号:US-12187735-B2 优先权日:2018-09-17 标 题:Matter of composition, synthesis, formulation and application of FL118 platform positions 7 and 9-derived analogues for treatment of human disease 发明人:LING XIANG; LI QINGYONG; LI FENGZHI 权利人:CANGET BIOTEKPHARMA LLC 摘要:Described herein, are the chemical synthesis, matter of compositions, formulation, function, methods and uses of the FL118 platform Positions 7 and/or 9-derived analogues for treating cancer or other human diseases. Compounds derived from chemical modifications of the FL118 platform are employed alone or in combination with other anti-cancer agents to preclude, eliminate or reverse cancer phenotypes. This invention intends to realize unique personalized cancer treatment (personalized precision medicine) through application of a series of structural relevant individual FL118 platform-derived analogues, which target multiple cellular human disease-relevant proteins and their signaling pathways.
专利号:US-2025092058-A1 优先权日:2018-09-17 标 题 :Matter of composition, synthesis, formulation and application of fl 118 platform positions 7 and 9-derived analogues for treatment of human disease 发明人:LING XIANG; LI QINGYONG; LI FENGZHI 权利人:CANGET BIOTEKPHARMA LLC 摘要:Described herein, are the chemical synthesis, compounds, methods and uses of the fluoroaryl-substituted derivatives at the FL118 position 7, which target multiple cellular human disease-relevant proteins and their signaling pathways.
专利号:EP-1682546-B1 优先权日:2003-10-30 标题:Peptidomimetic compounds, stereoselective process for their preparation, their use as biologically active synthetic intermediates 发明人:SCOLASTICO CARLO; MANZONI LEONARDO; COLOMBO MATTEO; BRACCI ANTONIO 权利人:CISI SCARL 摘要:The invention relates to novel cyclic peptidomimetic compounds having an azabicycloalkane structure, useful as intermediates in the preparation of alphaVBeta3 and alphaVBeta5 integrin antagonists, intended, for example, for the treatment of altered angiogenic phenomena; the invention also concerns a process for the stereoselective synthesis of said cyclic peptidomimetic compounds and biologically active derivatives thereof. Formula (I) wherein: n is 1 or 2, R1 is H, (C1-C4)alkyl,benzyl or a protective group; R2 is H or a protective group; R3 is H or heteroalkyl or a protective group; Their salts, racemic mixtures,individual enantiomers ,individual diastereoisomers and mixtures thereof in any proportion.
专利号:JP-2005239646-A 优先权日:2004-02-27 标题:Stereoselective synthesis of pyrrolidine derivatives
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合成参考文献
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