CAS: 21075-83-2; 1-Boc-1-Methylhydrazine

相似化合物

1073-62-7 20570-96-1 302-15-8

上下游产品

肼基甲酸叔丁酯 T-Butoxycarbonylhydrazine 870-46-2

📜Tert-Butyl (1,3-Dioxoisoindolin-2-yl)(Methyl)Carbamate置于甲基肼体系中,用 四氢呋喃 用作溶剂,以65%的收率获得1-Boc-1-甲基肼
参考文献:使用mitsunobu协议通过n-酰基或n-烷氧基羰基氨基邻苯二甲酰亚胺的烷基化反应合成1,1取代的肼.
标题:使用mitsunobu协议通过n-酰基或n-烷氧基羰基氨基邻苯二甲酰亚胺的烷基化反应合成1,1取代的肼.
摘要:N-酰基和n-烷氧基羰基氨基邻苯二甲酰亚胺使用方便的反应制备,并有效地用作mitsunobu反应中的酸伙伴.该反应使它们被伯,仲或苄基烷基化.这些n-取代的氨基邻苯二甲酰亚胺的反应性和pk(a)值的比较表明,在这种情况下,Mitsunobu反应的成功似乎更多地取决于空间而不是电子效应.最终的脱邻苯二甲酰化步骤导致制备1,1-取代肼的有效方法.
Doi:10.1021/jo000225S

专利信息

专利号:US-8026375-B2
优先权日:2007-04-13
标题:Transition metal catalyzed synthesis of N-aminoindoles
发明人：HALLAND NIS; NAZARE MARC; LINDENSCHMIDT ANDREAS; RKYEK OMAR; URMANN MATTHIAS; ALONSO JORGE
权利人:SANOFI AVENTIS
摘要:The present invention relates to a process for the regioselective synthesis of compounds of the formula I, n nwherein R0; R1; R2; R3; R4; R5; R6; A1; A2; A3; A4, Q, T and J have the meanings indicated in the claims. The present invention provides a direct transition metal catalyzed process to a wide variety of multifunctional N-aminoindole or N-amino-azaindoles of the formula I from 2-halo-phenylacetylenes or (2-sulfonato)phenyl-acetylenes and N,N-disubstituted hydrazines, useful for the production of pharmaceuticals, diagnostic agents, liquid crystals, polymers, herbicides, fungicidals, nematicidals, parasiticides, insecticides, acaricides and arthropodicides.

专利号:US-5602231-A
优先权日:1991-06-14
标题 :Process for making peptides
发明人：COTTON RONALD; GILES MICHAEL B
权利人:ZENECA LTD
摘要:A process for the solid phase synthesis of peptides containing a C-terminal aza-amino acid, for example the decapeptide goserelin, which comprises: (i) reacting an active ester or imidazolide of an N-protected aza-amino acid either with an appropriate reactive solid support in the case of the synthesis of a peptide containing a C-terminal aza-amino acid, or with a peptide which is attached to a solid support in the case of the synthesis of a peptide containing a non-C-terminal aza-amino acid; (ii) carrying out further conventional solid phase peptide synthesis steps to add sequentially further amino acids, to form a peptide with the required amino acid sequence bound to the solid support; (iii) cleaving the peptide from the solid support, and optionally (iv) reacting the product so formed with hydrazine to remove any acyl groups which have been formed on serine, arginine, tyrosine, threonine or hydroxyproline during the synthesis.

专利号:US-11377359-B2
优先权日:2018-10-11
标题:Process for producing liquid polysilanes and isomer enriched higher silanes
发明人：NIKIFOROV GRIGORY; HUSSON GUILLAUME; ITOV GENNADIY; WANG YANG
权利人:AIR LIQUIDE; AIR LIQUIDE AMERICAN
摘要:Synthesis of silanes with more than three silicon atoms are disclosed (i.e., SinH(2n+2) with n=4-100). More particularly, the disclosed synthesis methods tune and optimize the isomer ratio by selection of process parameters such as temperature, residence time, and the relative amount of starting compounds, as well as selection of proper catalyst. The disclosed synthesis methods allow facile preparation of silanes containing more than three silicon atoms and particularly, the silanes containing preferably one major isomer. The pure isomers and isomer enriched mixtures are prepared by catalytic transformation of silane (SiH4), disilane (Si2H6), trisilane (Si3H8), and mixtures thereof.

专利号:AU-2008238379-A1
优先权日:2007-04-13
标题:A transition metal catalyzed synthesis of N-aminoindoles

专利号:EP-2134682-A1
优先权日:2007-04-13
标题 :A transition metal catalyzed synthesis of n-aminoindoles

专利号:CA-2683578-A1
优先权日:2007-04-13
标题:A transition metal catalyzed synthesis of n-aminoindoles