CAS: 19457-55-7; (8R,9S,10R,13S,14S)-10,13-Dimethyl-6-Methylidene-1,2,7,8,9,11,12,14,15,16-Decahydrocyclopenta[a]Phenanthrene-3,17-Dione

上下游产品

CAS号50-00-0 甲醛 | CAS号63-05-8 雄烯二酮 | CAS号462-95-3 二乙氧基甲烷 | CAS号57144-06-6 (8R,9S,10R,13S,... | CAS号53-43-0 去氢表雄酮 | CAS号905-30-6 3-pyrrolidin-1-... | CAS号107868-30-4 依西美坦

3-Methoxy-6-Hydroxymethyl-17-Oxo-Androstadien-(3,5)置于溶剂黄146体系中,化学反应生成依西美坦中间体
参考文献:修饰的类固醇激素-Xxxiii:甾体6-甲酰基-3-烷氧基-3,5-二烯及其一些转化
标题:修饰的类固醇激素-Xxxiii:甾体6-甲酰基-3-烷氧基-3,5-二烯及其一些转化
摘要:甾族3-烷氧基-3,5-二烯与vilsmeier试剂之间的反应导致相应的6-甲酰基衍生物的高产率.这些中间体被还原成3-烷氧基-6-羟甲基-3,5-二烯,其经酸脱水成6-亚甲基-4-En-3-One.
Doi:10.1016/s0040-4020(01)98622-3

专利信息

专利号:WO-2009034398-A1
优先权日:2007-09-11
标题:Process for the synthesis of 6-hydroxymethyl-l,4- androstadien-3.17-dione
发明人：HANTOS GABOR; HERINE BERTA MONIKA; TEGDES ANIKO; BARTHO ISTVAN; DEVENYI TAMAS; GALIK GYOERGY; PECSNE RAZSO AGNES; GANCSOS VALERIA; KOENCZOEL KALMAN; MAHO SANDOR
权利人:RICHTER GEDEON NYRT; HANTOS GABOR; HERINE BERTA MONIKA; TEGDES ANIKO; BARTHO ISTVAN; DEVENYI TAMAS; GALIK GYOERGY; PECSNE RAZSO AGNES; GANCSOS VALERIA; KOENCZOEL KALMAN; MAHO SANDOR
摘要:The invention relates to a novel process for the synthesis of 6-hydroxymethyl-l,4- androstadien-3,17-dione which means dehydrogenating 6-hydroxymethyl-4-androsten- 3,17-dione in the presence of a biocatalyst.

专利号:US-4990635-A
优先权日:1988-01-26
标 题:Synthesis of 6-methylene derivatives of androsta-1,4-diene-3,17-dione
发明人：LONGO ANTONIO; LOMBARDI PAOLO
权利人:ERBA CARLO SPA
摘要:The invention relates to a new process for the preparation of known aromatase inhibitors of the following formula (I) ##STR1## wherein each of R 1 and R 3 , independently, is hydrogen or C 1 -C 6 alkyl; n R 2 is hydrogen, halogen or C 1 -C 6 alkyl; and n R 4 is hydrogen or fluorine; n the process comprising submitting to Mannich reaction a compound of formula (II) ##STR2## wherein R 1 , R 2 , R 3 and R 4 are as defined above and R is a lower alkyl group, and then dehydrogenating the respective 6-methylene-3-oxo-Δ 4 -steroid derivative thus obtained, by methods known per se.

专利号:EP-0326340-B1
优先权日:1988-01-26
标 题 :Improvement in the synthesis of 6-methylene derivatives of androsta-1,4-diene-3,17-dione

专利号:CA-1319680-C
优先权日:1988-01-26
标 题:Synthesis of 6-methylene derivatives of androsta-1,4-diene-3,17-dione

专利号:AU-607565-B2
优先权日:1988-01-26
标 题:Improvement in the synthesis of 6-methylene derivatives of androsta-1, 4-diene-3,17-dione

专利号:EP-0326340-A2
优先权日:1988-01-26
标 题 :Improvement in the synthesis of 6-methylene derivatives of androsta-1,4-diene-3,17-dione