CAS: 192203-60-4; Carboxypeptidase G2 (Cpg2) Inhibitor
该化合物是一种合成化合物,其特点是经硫酯功能组群改造的谷酸脊柱,其特征是存在一个甲基氧基组,该组群有助于其独特的化学特性和潜在的生物活动.硫酸联系增强了其反应性,使其对各种化学合成应用感兴趣.作为L-甘酸的衍生物,它保留氨酸的氨基碳球酸和矿物质功能,可以参与各种化学反应,包括聚氨基氨基氨基酸的粘合物粘合物粘合物的形成.甲基氧基化合物可影响该化合物的溶性和极性,影响其与生物系统的互动.
- 英文名称Carboxypeptidase G2 (Cpg2) Inhibitor
- 中文名称N-[[(4-甲氧基苯基)硫]羰基]-L-谷氨酸
- IUPAC名称(((4-methoxyphenyl)thio)carbonyl)-L-glutamic acid
- 其它别名N-[[(4-Methoxyphenyl)Thio]Carbonyl]-L-Glutamic Acid; Carboxypeptidase G2 (Cpg2) Inhibitor; Cpg2 Inhibitor; L-Glutamic Acid, N-[[(4-Methoxyphenyl)Thio]Carbonyl]-; Carboxypeptidase G2 Inhibitor; Cpg2 Inhibitor; L-Glutamic Acid; N-[[(4-Methoxyphenyl)Thio]Carbonyl]-; N-[[(4-Methoxyphenyl)Thio]Carbonyl]-; (2S)-2-[(4-Methoxyphenyl)Sulfanylcarbonylamino]Pentanedioicaci
- CAS编号192203-60-4
- MFCD编号:MFCD16039212
- 分子式:C13H15NO6S分子量:313.33
- 产品CID: 973010
- 产品分类生物化工 → 氨基酸及其衍生物 → 谷氨酸类衍生物
物理性质
MSDS等安全信息
- 警示词warning
- 危险描述H303 may be harmful by ingestion +h313 may be harmful by skin contact +h2413 may be harmful by inhalation
- 防范说明P264 wash thoroughly after treatmentp280 wear protective gloves / wear protective clothing / wear protective eye masks / wear protective masksp305 if in eyesp351 rinse carefully with water for a few minutesp338 remove contact lenses (if any) and easy to operate, continue rinsingp337 if eye irritation persistsp2393 get medical advice / care
- 安全声明H303 may be harmful by ingestion +h313 may be harmful by skin contact +h2413 may be harmful by inhalation
上下游产品
4-Methoxybenzenethiol L-glutamic acid di-tert-butyl ester hydr°Chloride carbonyl>-L-glutamatedi-tert-butyl (4-nitrophenyl)oxycarbonyl-L-glutamate合成工艺路线路线简述
📜L-谷氨酸二叔丁酯盐酸盐置于盐酸,三乙胺体系中,用 二氯甲烷 用作溶剂,化学反应 6.58H,反应生成N-[[(4-甲氧基苯基)硫]羰基]-L-谷氨酸
参考文献:Novel Inhibitors Of Carboxypeptidase G2 (Cpg2): Potential Use In Antibody-Directed Enzyme Prodrug Therapy
标题:Novel Inhibitors Of Carboxypeptidase G2 (Cpg2): Potential Use In Antibody-Directed Enzyme Prodrug Therapy
摘要:The Design And Synthesis Of Potent Thiocarbamate Inhibitors For Carboxypeptidase Ga Are Described. The Best Thiocarbamate Inhibitor N-(P-Methoxybenzenethiocarbonyl)Amino-L-Glutamic Acid 6D,Chosen For Preliminary Investigations Of In Vitro Antibody-Directed Enzyme Prodrug Therapy (Adept),Abrogated The Cytotoxicity Of A Combination Of A5B7-Carboxypeptidase G(2) Conjugate And Prodrug Pgp (N-P-{n,N-Bis (2-Chloroethyl)Amino}Phenoxycarbonyl-L-Glutamate) Toward Ls174T Cells. This Is The First Report Of A Small-Molecule Enzyme Inhibitor Proposed For Use In Conjunction With The Adept Approach.
Doi:10.1021/jm990004I
海关参考信息
- 2905121000-正丙醇
2905130000-正丁醇
2912110000-甲醛
2912120000-乙醛 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
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供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
合成参考文献
参考文献:10.1021/jm990004i
摘要:Khan TH, Eno-Amooquaye EA, Searle F, Browne PJ, Osborn HMI, Burke PJ. Novel Inhibitors of Carboxypeptidase G2 (CPG2): Potential Use in Antibody-Directed Enzyme Prodrug Therapy. J. Med. Chem. 1999 Mar 01;42(6):951–6. doi: 10.1021/jm990004i.
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