CAS: 1851-09-8; 2-((4-Chlorophenyl)Sulfonyl)Acetonitrile

上下游产品

2,3-dichloroacrylonitrile sodium p-chlorobenzenesulphinate chloroacetonitrile 4-chlorophenylthioacetonitrile N-hydroxy-acetamidine2-(4-chloro-benzenesulfonyl)-N-hydroxy-acetamidine 2-(4-chloro-benzenesulfonyl)-thioacetamide dichloro-(4-chloro-benzenesulfonyl)-acetonitrile (4-chloro-benzenesulfonyl)-hydroxyimino-acetonitrile

📜(4-氯苯基硫)乙腈置于双氧水,溶剂黄146体系中,化学反应生成(4-氯苯磺酰)乙腈
参考文献:咪唑氮氧化物与氰乙酸乙酯的意外醛催化反应
标题:咪唑氮氧化物与氰乙酸乙酯的意外醛催化反应
摘要:2-未取代咪唑n-氧化物与氰基乙酸乙酯和芳香醛的反应导致形成2-氰基-2-(1,3-二氢-2H-咪唑-2-亚基)乙酸乙酯.该反应通过最初的 [3+2] 环加成反应进行,然后是环加合物的裂解和醛的再生,这基本上起催化作用.
Doi:10.1055/s-0039-1691527

专利信息

专利号:WO-9837078-A1
优先权日:1997-02-20
标题 :Solid phase and combinatorial synthesis of substituted thiophenes and of arrays of substituted thiophenes
发明人：DOERWALD FLORENCIO ZARAGOZA
权利人:NOVO NORDISK AS
摘要:A solid phase method for the synthesis of a plurality of differently substituted thiophenes with a wide variety of side-chain substituents as compounds of potential therapeutic interest. The thiophenes are prepared by reaction of a substrate-bound primary or secondary amine with a thiophosgene equivalent and reaction of the resulting intermediate with an acceptor-substituted acetonitrile in the presence of a base. Alkylation with an appropriate alkyl halide, followed by Thorpe-Ziegler-cyclization yields differently substituted, support-bound 3-aminothiophenes. These may be screened on the substrate or cleaved from the substrate and then screened in solution. Alternatively, the resin-bound 3-amino thiophenes or the synthetic intermediates can be subjected to further synthetic transformations (N-acylation, reduction) on the support, which permits the preparation of further therapeutically interesting compounds. The efficient synthesis of a wide variety of thiophenes using automated synthesis technology of the present method makes these compounds attractive candidates for the generation and rapid screening of diverse thiophene-based libraries. The method disclosed here provides an easy and fast access to highly diverse heterocyclic compounds of therapeutic interest, amenable to automatization.

专利号:US-9908846-B2
优先权日:2014-02-21
标题:Composition, synthesis, and use of new arylsulfonyl isonitriles
发明人：FLEMING FRASER FERGUSSON; LUJAN MONTELONGO JESUS ARMANDO
权利人:DUQUESNE UNIV OF THE HOLY GHOST; UNIV HOLY GHOST DUQUESNE
摘要:This invention relates to novel isonitriles, including arylsulfonyl isonitriles, and methods for their synthesis. The isonitriles include a conjugated ring system. The structure is designed with the flexibility to have multiple substitution patterns. The isonitriles may be used in applications including, but not limited to, pharmaceutical compositions.

专利号:US-2015239833-A1
优先权日:2014-02-21
标题:Composition, synthesis, and use of new arylsulfonyl isonitriles

专利号:CN-116768814-A
优先权日:2023-06-30
标 题 :A kind of synthesis method of 4-sulfonyl-2,5-bis(trifluoromethyl)oxazole compound

专利号:CN-110183379-B
优先权日:2019-06-22
标 题 :Synthesis method and application of copper-catalyzed one-pot method for preparing C-4-sulfonyl substituted isoquinolone compounds