CAS: 183673-71-4; 4-Amino-1-(Tert-Butoxycarbonyl)Piperidine-4-Carboxylic Acid

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183673-66-7 288154-16-5 189321-65-1

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CAS号183673-68-9 2,4-二氧代-1,3,8-三... | CAS号24424-99-5 二碳酸二叔丁酯 | CAS号13625-39-3 1,3,8-三氮杂螺[4.5]... | CAS号40064-34-4 4,4-哌啶二醇盐酸盐 | CAS号79099-07-3 1-B°C-4-哌啶酮 | CAS号183673-70-3 8-B°C-2,4,8-三氮杂... | CAS号41979-39-9 4-氧代哌啶酮盐酸盐 | CAS号73390-11-1 4,4-哌啶二醇 | CAS号321997-89-1 1-B°C-4-氨基哌啶-4-甲酸甲酯 | CAS号183673-66-7 N-叔丁氧羰基4-(FM°C-... | CAS号189321-65-1 1-B°C-4-(B°C-氨基... | CAS号288154-16-5 4-苄氧基羰基氨基哌啶-1,4... | CAS号495414-58-9 4-烯丙基-哌啶-1,4-二羧酸叔丁酯

1-T-叔丁氧羰基-哌啶-4-螺-5'-[1',3'-二-T-叔丁氧羰基]海因置于水,Sodium Hydroxide体系中,用 四氢呋喃 用作溶剂,以52 %的收率获得n-Boc-4-氨基-4-羧酸哌啶
参考文献:通过用非蛋白氨基酸对抗菌肽进行结构修饰来增强化学稳定性
标题:通过用非蛋白氨基酸对抗菌肽进行结构修饰来增强化学稳定性
摘要:多重耐药细菌 (Mdrb) 仍然对人类构成重大威胁,每年导致超过 120 万人死亡.为了有效地解决这个问题,开发具有不同作用机制的治疗剂至关重要.抗菌肽 (Amp) 已成为对抗传染病(特别是 Mdrb)的有前途的下一代疗法.通过靶向微生物膜并诱导裂解,Amp 可以有效抑制微生物生长,使其不易产生耐药性.为了优化 Amp 的功效,我们取得了许多结构上的进步.此前,我们开发了 17Kkv-Aib,它是 Magainin 2 (Mag2) 肽的衍生物,通过掺入 α,α-二取代氨基酸 (Daa) 来调节其二级结构.17Kkv-Aib 对革兰氏阳性和革兰氏阴性细菌(包括多重耐药铜绿假单胞菌 (Mdrp))具有有效的抗菌活性,对人红细胞的溶血活性极小.然而,17Kkv-Aib 面临着对消化酶敏感性的挑战,阻碍了其作为抗菌剂的潜力.在本研究中,我们设计并合成了17Kkv-Aib的衍生物,用4-氨基哌啶-
Doi:10.3390/antibiotics12081326

专利信息

专利号:US-2025129021-A1
优先权日:2023-09-19
标 题:Small molecule protein synthesis modulators
发明人：GYGI DAVID; BAHMANYAR SOGOLE SAMI; HAMANN LAWRENCE
权利人:INTERDICT BIO INC
摘要:The present disclosure provides compounds of the formulae herein (e.g., Formula (I), Formula (V)), and pharmaceutically acceptable salts thereof, which are useful for modulating protein synthesis (e.g., modulating synthesis of BCL-2, MYC, CCND1, MCL-1, ALK, KRAS-G12D). The present disclosure also provides pharmaceutical compositions and kits comprising the compounds, or pharmaceutically acceptable salts thereof, and methods of treating or preventing diseases or disorders (e.g., diseases or disorders associated with BCL-2, MYC, CCND1, MCL-1, ALK, KRAS-G12D) by administering to a subject in need thereof the compounds, or pharmaceutically acceptable salts thereof, or pharmaceutical compositions thereof.

专利号:US-9574189-B2
优先权日:2005-12-01
标题:Enzymatic encoding methods for efficient synthesis of large libraries
发明人：FRANCH THOMAS; LUNDORF MIKKEL DYBRO; JACOBSEN SØREN NYBOE; OLSEN EVA KAMPMANN; ANDERSEN ANNE LEE; HOLTMANN ANETTE; HANSEN ANDERS HOLM; SØRENSEN ANDERS MALLING; GOLDBECH ANNE; DE LEON DAEN; KALDOR DITTE KIEVSMOSE; SLØK FRANK ABILDGAARD; HUSEMOEN GITTE NYSTRUP; DOLBERG JOHANNES; Jensen Kim Birkebæ; PEDERSEN LENE; NØRREGAARD-MADSEN MADS; GODSKESEN MICHAEL ANDERS; GLAD SANNE SCHRØDER; NEVE SØREN; THISTED THOMAS; KRONBORG TINE TITILOLA AKINLEMINU; SAMS CHRISTIAN KLARNER; FELDING JAKOB; FRESKGÃ…RD PER-OLA; GOULIAEV ALEX HAAHR; PEDERSEN HENRIK
权利人:FRANCH THOMAS; LUNDORF MIKKEL DYBRO; JACOBSEN SØREN NYBOE; OLSEN EVA KAMPMANN; ANDERSEN ANNE LEE; HOLTMANN ANETTE; HANSEN ANDERS HOLM; SØRENSEN ANDERS MALLING; GOLDBECH ANNE; DE LEON DAEN; KALDOR DITTE KIEVSMOSE; SLØK FRANK ABILDGAARD; HUSEMOEN GITTE NYSTRUP; DOLBERG JOHANNES; Jensen Kim Birkebæ; PEDERSEN LENE; NØRREGAARD-MADSEN MADS; GODSKESEN MICHAEL ANDERS; GLAD SANNE SCHRØDER; NEVE SØREN; THISTED THOMAS; KRONBORG TINE TITILOLA AKINLEMINU; SAMS CHRISTIAN KLARNER; FELDING JAKOB; FRESKGÃ…RD PER-OLA; GOULIAEV ALEX HAAHR; PEDERSEN HENRIK; NUEVOLUTION AS
摘要:Disclosed is a method for obtaining a bifunctional complex comprising a molecule linked to a single stranded identifier oligonucleotide, wherein a nascent bifunctional complex comprising a chemical reaction site and a priming site for enzymatic addition of a tag is a) reacted at the chemical reaction site with one or more reactants, and b) reacted enzymatically at the priming site with one or more tag(s) identifying the reactant(s).

专利号:US-11702652-B2
优先权日:2005-12-01
标题:Enzymatic encoding methods for efficient synthesis of large libraries

专利号:US-2009264300-A1
优先权日:2005-12-01
标题 :Enzymatic encoding methods for efficient synthesis of large libraries

专利号:US-2020216836-A1
优先权日:2005-12-01
标题 :Enzymatic encoding methods for efficient synthesis of large libraries

专利号:EP-1957644-B1
优先权日:2005-12-01
标 题 :Enzymatic encoding methods for efficient synthesis of large libraries