CAS: 17804-35-2; Benomyl

该化合物是一种系统性杀真菌剂,属于苯并米达佐乐类,主要用于农业,以控制作物中各种真菌疾病;其化学结构具有苯并米达佐乐环,这对杀真菌活动至关重要;Bemunicols行为,它阻止真菌细胞分裂,具体针对管状素聚合,干扰微囊形成,最终导致细胞死亡;通常用作粉末或颗粒制剂,以其广泛频谱的功效来对抗微粒,叶点和根质腐烂等病原体;Bemomol在正常条件下相对稳定,但在接触强酸或碱时可降解;在虫害管理方面有效,但对环境的影响和潜在人类健康影响的关切导致对某些地区进行监管检查,导致对其使用的限制或禁止;适当处理和应用对于尽量减少农业做法中使用该物质的风险至关重要.

结构式图片

欧盟法规

统一分类与标签ECHA物质食品接触材料-禁用CMR物质ECHA物质工作场所安全标识要求C&L通报化妆品禁用物质清单REACH预注册废弃物危险特性清单

上下游产品

CAS号63059-33-6 5-丁基海因酸

合成工艺路线路线简述

  • 合成目标产物 Benomyl 主要起始原料 Carbamic Acid, (1,3-Dihydro-2H-Benzimidazol-2-Ylidene)-, Methyl Ester (9CI) And Butyl Isocyanate
  • (文献来源)合成步骤主要原料 Carbamic Acid, (1,3-Dihydro-2H-Benzimidazol-2-Ylidene)-, Methyl Ester (9Ci) 和 Butyl Isocyanate
2-氨基苯并咪唑 反应生成苯菌灵
参考文献:Martin,D.,Sitzungsber. Akad. Wiss. Ddr. Math.-Naturwiss.-Techn.,1983,N 2N,40-51
标题:Martin,D.,Sitzungsber. Akad. Wiss. Ddr. Math.-Naturwiss.-Techn.,1983,N 2N,40-51

海关参考信息

专利信息


专利号:WO-9217496-A1
优先权日:1991-03-18
标题 :Isolation and sequence of the acetyl coa:deacetylcephalosporin acetyltransferase gene
发明人:MATHISON LORILEE; SOLIDAY CHARLES L; RAMBOSEK JOHN A
权利人:PANLABS INC
摘要:The invention relates to a DNA sequence with a nucleotide sequence encoding a polypeptide in a host cell having Cephalosporin C synthetase (DAC acetyltransferase) activity which is the last enzyme in the synthesis of cephalosporins. Embodiments of the invention relate to methods and compositions for detecting the gene or its product, mutants and hybrids of the gene, replicative cloning and expression vectors, and processes for preparing recombinant DAC acetyltransferase polypeptide useful for host cell synthesis of, as well as cell-free synthesis of natural and synthetic cephalosporin antibiotics.

专利号:US-5662898-A
优先权日:1990-08-20
标 题 :Genes for the synthesis of antipathogenic substances
发明人:LIGON JAMES M; HILL DWIGHT STEVEN; LAM STEPHEN TING; HAMMER PHILIP E
权利人:CIBA GEIGY CORP
摘要:The present invention is directed to the production of an antipathogenic substance (APS) in a host via recombinant expression of the polypeptides needed to biologically synthesize the APS. Genes encoding polypeptides necessary to produce particular antipathogenic substances are provided, along with methods for identifying and isolating genes needed to recombinantly biosynthesize any desired APS. The cloned genes may be transformed and expressed in a desired host organisms to produce the APS according to the invention for a variety of purposes, including protecting the host from a pathogen, developing the host as a biocontrol agent, and producing large, uniform amounts of the APS.

专利号:US-7510852-B2
优先权日:2002-10-18
标题:Biosynthetic genes and host cells for the synthesis of polyketide antibiotics and method of use
发明人:ROYER MONIQUE; GABRIEL DEAN W; FRUTOS ROGER; ROTT PHILIPPE
权利人:CIRAD; UNIV FLORIDA
摘要:Three gene clusters that together encode albicidin biosynthesis, the complete gene DNA sequences, and the deduced protein sequences for the enzymes and methods for using the DNA sequences are disclosed and discussed as well as methods for plant protection and creating new antibiotics. The novel Albicidin family of antibiotics is disclosed and their structure deduced.

专利号:WO-2025056767-A1
优先权日:2023-09-15
标题 :Process for the preparation of enantiomerically enriched aliphatic amines
发明人:BOU HAMDAN FARHAN; GODINEAU EDOUARD; SMEJKAL TOMAS; DUMEUNIER RAPHAEL; BOUSSEMGHOUNE MOHAMED ABDELOUAHAB; BLUM MATHIAS
权利人:SYNGENTA CROP PROTECTION AG
摘要:The present invention relates to a process for the preparation of enantiomerically enriched cyclobutylamines of formula (I) from α-tertiary cyclobutanones and reacting said enantiomerically enriched cyclobutylamines to enantiomerically enriched cyclobutylamides. Such compounds are useful intermediates in the synthesis of microbiocidal thiazole compounds.

专利号:US-2016073631-A1
优先权日:2013-03-04
标 题 :Process for the preparation of dihydropyrrole derivatives
发明人:EL QACEMI MYRIEM; SMITS HELMARS; CASSAYRE JEROME YVES; MULHOLLAND NICHOLAS PHILLIP; RENOLD PETER; GODINEAU EDOUARD; PITTERNA THOMAS
权利人:SYNGENTA PARTICIPATIONS AG; SYNGENTA LTD
摘要:The present invention provides stereoselective processes for the preparation of compounds of formula (I) n n n n n n n n n n n n wherein n P is phenyl, naphthyl, a 6-membered heteroaryl group containing one or two nitrogen atoms as ring members, or a 10-membered bicyclic heteroaryl group containing one or two nitrogen atoms as ring members, and wherein the phenyl, naphthyl and heteroaryl groups are optionally substituted; n R 1 is chlorodifluoromethyl or trifluoromethyl; n R 2 is optionally substituted aryl or optionally substituted heteroaryl; n n is 0 or 1; n including the process comprising n (a-i) reacting a compound of formula II n n n n n n n n n n n n n n n n wherein P, R 1 and R 2 are as defined for the compound of formula I; n with nitromethane in the presence a chiral catalyst to give a compound of formula III n n n n n n n n n n n n n n n n wherein P, R 1 and R 2 are as defined for the compound of formula I; and n (a-ii) reductively cyclising the compound of formula III to give the compound of formula I. n n n n n The invention also provides intermediates useful for processes for the synthesis of compounds of formula (I).

专利号:US-7935704-B2
优先权日:2003-08-01
标 题 :Dehydrophenylahistins and analogs thereof and the synthesis of dehydrophenylahistins and analogs thereof
发明人:PALLADINO MICHAEL A; LLOYD GEORGE KENNETH; HAYASHI YOSHIO; NICHOLSON BENJAMIN
权利人:NEREUS PHARMACEUTICALS INC
摘要:Compounds represented by the following structure (I) are disclosed: n nas are methods for making such compounds, wherein said methods comprise reacting a diacyldiketopiperazine with a first aldehyde to produce an intermediate compound; and reacting the intermediate compound with a second aldehyde to produce the class of compounds with the generic structure, where the first aldehyde and the second aldehydes are selected from the group consisting of an oxazolecarboxaldeyhyde, imidazolecarboxaldehyde, a benzaldehyde, imidazolecarboxaldehyde derivatives, and benzaldehyde derivatives, thereby forming the above compound wherein R 1 , R 1 ′, R 1 ″, R 2 , R 3 , R 4 , R 5 , and R 6 , X 1 and X 2 , Y, Z, Z 1 , Z 2 , Z 3 , and Z 4 may each be separately defined in a manner consistent with the accompanying description. Compositions and methods for treating vascular proliferation are also disclosed.
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主要参考文献


1: Von Burg R. Benomyl. J Appl Toxicol. 1993 Sep-Oct;13(5):377-81. Review. Review. Review. Review. doi: 10.1093/carcin/bgv031. Review.
6: Van Gestel CA. Validation of earthworm toxicity tests by comparison with field studies: a review of benomyl, carbendazim, carbofuran, and carbaryl. Ecotoxicol Environ Saf. 1992 Apr;23(2):221-36. Review. doi: 10.4161/cc.19444. Epub 2012 May 1. Review.
8: Singh P, Rathinasamy K, Mohan R, Panda D. Microtubule assembly dynamics: an attractive target for anticancer drugs. IUBMB Life. 2008 Jun;60(6):368-75. doi: 10.1002/iub.42. Review. Review. Review. Review. Review. Review.

合成参考文献


参考文献:10.1080/19440049.2011.584069
摘要:Ribonnet L, van der Heiden E, Nobels I, Chaumont A, Remacle AS, De Saeger S, Schneider YJ, Scippo ML, Blust R, Pussemier L, Larondelle Y. Potential of an in vitro toolbox combined with exposure data as a first step for the risk assessment of dietary chemical contaminants. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2011 Sep;28(9):1136–58. doi: 10.1080/19440049.2011.584069.
参考文献:10.1007/s10653-011-9399-x
摘要:Srinivasulu M, Jaffer Mohiddin G, Subramanyam K, Rangaswamy V. Effect of insecticides alone and in combination with fungicides on nitrification and phosphatase activity in two groundnut (Arachis hypogeae L.) soils. Environ Geochem Health. 2012 Jun;34(3):365–74. doi: 10.1007/s10653-011-9399-x.
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