CAS: 175277-45-9; 2-Methoxy-5-(Trifluoromethyl)Pyridine

相似化合物

33252-63-0 121643-44-5 1552636-40-4

2-氯-5-碘吡啶置于potassium Fluoride,Copper(L) Iodide,1,10-菲罗啉,硼酸三甲酯,Sodium Hydride体系中,用 二甲基亚砜,N,N-二甲基甲酰胺 用作溶剂,化学反应 24.0H,反应生成2-甲氧基-5-三氟甲基吡啶
参考文献:铜催化烷氧基吡啶衍生物的三氟甲基化
标题:铜催化烷氧基吡啶衍生物的三氟甲基化
摘要:由于其药理学相关性,芳香和杂芳香核的三氟甲基化近年来引起了相当大的兴趣.我们研究了将简单的铜催化三氟甲基化方案扩展到烷氧基取代的碘代吡啶及其苯并类似物.三氟甲基化在所有情况下都顺利进行,所需的化合物被分离和表征.在 3-Iodo-4-甲氧基喹啉的三氟甲基化中,我们观测到伴随的 On 甲基迁移,导致三氟甲基化喹诺酮作为产物.总体而言,所描述的程序应有助于在药物化学中更广泛地使用铜催化的三氟甲基化.
Doi:10.3390/molecules25204766

专利信息

专利号:US-9163020-B2
优先权日:2013-07-17
标 题 :Azaindole compounds, synthesis thereof, and methods of using the same
发明人：SHIRUDE PRAVIN S; NAIK MARUTI N; SHINDE VIKAS NARAYAN; PEER MOHAMED SHAHUL HAMEED; CHATTERJI MONALISA; SHINDIL RADHA K
权利人:GLOBAL ALLIANCE FOR TB DRUG DEV; ASTRAZENECA AB; FOUNDATION FOR NEGLECTED DISEASE RES
摘要:The invention provides compounds of formula (I) and methods of treating a Mycobacterium infection or tuberculosis, or inhibiting DprE1 with the same.

专利号:EP-3021947-A1
优先权日:2013-07-17
标 题:Azaindole compounds, synthesis thereof, and methods of using the same

专利号:CA-2918487-A1
优先权日:2013-07-17
标 题 :Azaindole compounds, synthesis thereof, and methods of using the same

专利号:US-2015025087-A1
优先权日:2013-07-17
标题 :Azaindole compounds, synthesis thereof, and methods of using the same

专利号:CN-105636646-B
优先权日:2013-07-17
标题:Azaindole compounds, their synthesis and methods of use

专利号:CN-105636646-A
优先权日:2013-07-17
标 题 :Azaindole compounds, their synthesis and methods of use