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📜1-(4-硝基苯基)丁烷-1-酮置于吡啶,2,6-二叔丁基-4-甲基苯酚,盐酸羟胺,Sodium Acetate,Potassium Carbonate,2-(4,5-二氢-4,4-二甲基-2-恶唑基)吡啶,四(3,5-二(三氟甲基)苯基)硼酸钠,三[3,4-双(三氟甲基)苯基]膦,Palladium Dichloride体系中,用 乙醇,二氯甲烷,1,2-二氯乙烷 用作溶剂,化学反应 12.0H,反应生成4-硝基苯硼酸频哪醇酯
参考文献:通过配体促进的cc键活化来转化芳基酮.
标题:通过配体促进的cc键活化来转化芳基酮.
摘要:芳族亲电试剂(芳基卤化物,芳基醚,芳基酸,芳基腈等)与亲核试剂的偶联是合成芳基化合物的核心方法.由于芳基酮的丰度,通过碳-碳键活化以类似方式进行芳基酮的转化可大大扩展合成芳基化合物的工具箱.这种方法的探索性研究通常基于环应变释放和螯合辅助引发的碳-碳裂解,并且产物也仅限于特定的结构基序.在这里,我们报告了一种配体促进β-碳消除的策略,以激活碳-碳键,这导致芳基酮发生一系列转化,从而生成有用的芳基硼酸酯,以及联芳基,芳基腈和芳基烯烃.吡啶-恶唑啉配体的使用对于这种催化转化至关重要.据报道,通过简单的一锅操作,芳基酮的克级硼酸酯化反应.该策略的潜在效用还通过丙磺舒,阿达帕林和脱氧雌酮,芬芳类香囊素和载脂蛋白的天然产物的晚期药物分子多样化而得到证明.
Doi:10.1002/anie.202006740

专利信息

专利号:US-7250510-B2
优先权日:2005-08-24
标 题:Transition metal complexes of N-heterocyclic carbenes, method of preparation and use in transition metal catalyzed organic transformations
发明人：ORGAN MICHAEL G; O'BRIEN CHRISTOPHER J; KANTCHEV ASSAM ERIC B
权利人:TOTAL SYNTHESIS LTD
摘要:The present invention relates to catalysts of transition metal complexes of N-heterocyclic carbenes, their methods of preparation and their use in chemical synthesis. The synthesis, ease-of-use, and activity of the compounds of the present invention are substantial improvements over in situ catalyst generation. Further, the transition metal complexes of N-heterocyclic carbenes of the present invention may be used as precatalysts in metal-catalyzed cross-coupling reactions.

专利号:US-7122694-B2
优先权日:1998-11-06
标 题 :Hydroboronation process
发明人：MARCUCCIO SEBASTIAN MARIO; RODOPOULOS MARY; WEIGOLD HELMUT
权利人:BORON MOLECULAR PTY LTD
摘要:The invention relates to processes for the synthesis of aryl or alkene borates which comprises reacting: (i) an olefinic compound having a halogen or halogen-like substituent in a vinylic substitution position, or (ii) an aromatic ring having a halogen or halogen-like substituent in a ring substitution position, with a disubstituted monohydroborane in the presence of a Group 8-11 metal catalyst. The invention also relates to the use of these borates in coupling reactions. The invention further relates to certain disubstituted monohydroboranes and aryl or alkene borates.