CAS: 1544-68-9; 4-Fluorophenylisothiocyanate

该化合物是一种有机化合物,其特征是含有氟原子和一个附于一个苯环的异硫氰酸盐功能组,其分子结构特征是相对于异硫酸盐组的准位置用氟原子替代的苯基组,该化合物一般是无色的,可粉色黄色液体,具有显眼的味道,表明其再活性;已知该化合物在有机合成中使用,特别是在各种制药和农用化学物的制作过程中.异硫氰酸盐功能组具有高度反应性,允许增加核生殖反应,使其在硫柳亚氨和其他衍生物的合成中具有价值.此外,4-氟异硫氰酸物质展示了生物活动,已在各种研究中加以探讨,包括其在生物化学学学鉴定中作为试剂的潜力.与许多异硫氰酸盐一样,应对该物质的处理应谨慎,因为其潜在的毒性和刺激性.

结构式图片

相似化合物

113028-75-4 38985-64-7 141106-52-7

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CAS号75-15-0 二硫化碳 | CAS号371-40-4 4-氟苯胺 | CAS号463-71-8 硫光气 | CAS号1005-56-7 氯化硫代甲酸苯酯 | CAS号1053660-69-7 N-((aminothio)c... | CAS号3296-02-4 1-Azido-4-fluor... | CAS号404-52-4 U19963 | CAS号108-24-7 乙酸酐 | CAS号330-94-9 4-(4-氟苯)-3-氨基硫脲 | CAS号387-27-9 3-(4-氟苯基)-2-硫亚基... | CAS号348-40-3 2-氨基-6-氟苯并噻唑 | CAS号14210-24-3 1,1-dichloro-N-... | CAS号141300-33-6 brn 4880030 | CAS号141300-23-4 5-amino-6-(4-fl... | CAS号459-05-2 4-氟苯硫脲 | CAS号1544-79-2 1-(4-fluorophen... | CAS号331-00-0 3-(4-fluorophen... | CAS号348-45-8 N-(4-氟苯基)苯并噻唑-2-胺

合成工艺路线路线简述

    N-((Aminothio)Carbonothioyl)-4-Fluoroaniline置于lead(II) Nitrate体系中,用 水 用作溶剂,化学反应 1.0H,反应生成4-氟苯基异硫氰酸酯
    参考文献:含氟吡啶并[2,3-D]嘧啶衍生物的新型合成
    标题:含氟吡啶并[2,3-D]嘧啶衍生物的新型合成
    摘要:通过2-氨基-3-氰基-4,6-的反应以高收率合成了絮凝的4-亚氨基-3,5,7-三取代-吡啶[2,3-D]嘧啶-2(1H)硫酮.双取代吡啶与各种芳基异硫氰酸酯.这些新型产品已通过元素分析,Ir,1 H和19 F NMR光谱研究进行了表征.
    Doi:10.1016/s0022-1139(00)81031-3

    专利信息


    专利号:US-7678789-B2
    优先权日:2005-02-11
    标 题 :[1,2,4]-dithiazoli(di)ne derivatives, inducers of gluthathione-S-transferase and NADPH quinone oxido-reductase, for prophylaxis and treatment of adverse conditions associated with cytotoxicity in general and apoptosis in particular
    发明人:FEENSTRA ROELOF W; KEIZER HISKIAS G; PRAS-RAVES MARIA L; VAN VLIET BERNARD J; VAN SCHARRENBURG GUSTAAF J M
    权利人:SOLVAY PHARM BV
    摘要:The present invention relates to 5-imino-5H-[1,2,4]-dithiazol-3-yl-amine and [1,2,4]-dithiazolidine-3,5-diylidene-diamine derivatives as inducers of gluthathione-S-transferase (GST) and NADPH quinone oxidoreductase (NQO), to methods for the preparation of these compounds and to novel intermediates useful for the synthesis of said [1,2,4]-dithiazoli(di)ne derivatives. The invention also relates to the use of a compound disclosed herein for the treatment of adverse conditions associated with cytotoxicity in general and apoptosis in particular. The invention relates to compounds of the general formula (I): n nwhereinn nwherein the symbols have the meanings given in the specification.

    专利号:EP-1851209-B1
    优先权日:2005-02-11
    标题:[1,2,4]-dithiazoli(di)ne derivatives, inducers of gluthathione-s-transferase and nadph quinone oxido-reductase, for prophylaxis and treatment of adverse conditions associated with cytotoxicity in general and apoptosis in particular
    发明人:FEENSTRA ROELOF W; KEIZER HISKIAS G; PRAS-RAVES MARIA L; VAN VLIET BERNARD J; VAN SCHARRENBURG GUSTAAF J
    权利人:ABBOTT HEALTHCARE PRODUCTS BV
    摘要:The present invention relates to 5-imino-5H-[1,2,4]-dithiazol-3-yl-amine and [1,2,4]- dithiazolidine-3,5-diylidene-diamine derivatives as inducers of glutha-thione-S- transferase (GST) and NADPH quinone oxidoreductase (NQO), to methods for the preparation of these compounds and to novel intermediates useful for the synthesis of said [1,2,4]-dithiazoli(di)ne derivatives. The invention also relates to the use of a compound disclosed herein for the manufacture of a medicament useful in the for prophylaxis and treatment of adverse conditions associated with cytotoxicity in general and apoptosis in particular. The invention relates to compounds of the general formula (I): wherein the symbols have the meanings given in the specification.

    专利号:US-2024215280-A1
    优先权日:2022-10-31
    标 题:In situ core/shell perovskite nanocrystal material, method of preparation thereof, and light emitting device comprising the same
    发明人:LEE TAE-WOO; KIM JOO SUNG
    权利人:SEOUL NAT UNIV R&DB FOUNDATION; PEROLED CO LTD
    摘要:The present inventive concept relates to an in situ core/shell perovskite nanocrystal film formed by an in situ nanocrystal synthesis process, a method for producing the same, and a light emitting device comprising the same as a light-emitting layer. The in situ core/shell perovskite nanocrystal film formed by the in situ nanocrystal synthesis process according to the present inventive concept exhibits a strong charge confinement effect by nanocrystal formation, and can simultaneously greatly improve the luminescence efficiency and lifetime by maintaining the fast charge transport capability of polycrystalline perovskite.

    专利号:US-7875707-B2
    优先权日:2002-05-03
    标 题:Disaccharides for drug discovery
    发明人:MEUTERMANS WIM; WEST MICHAEL; ADAMSON GEORGE; THANH LE GIANG; DRINNAN NICHOLAS B; ABBENANTE GIOVANNI; BECKER BERND; GRATHWOHL MATTHIAS; RAJARATNAM PREMRAJ; TOMETZKI GERALD
    权利人:ALCHEMIA LTD
    摘要:Methods are described for the preparation of combinatorial libraries of potentially biologically active disaccharide compounds. These compounds are variously functionalized, with a view to varying lipid solubility size, function an other properties, with the particular aim of discovering novel drug or drug-like compounds, or compounds with useful properties. The invention provides intermediates, processes and synthetic strategies for the solution or solid phase synthesis of disaccharides, variously functionalized about the sugar ring, including the addition of aromaticity and charge, and the placement of pharmaceutically useful groups and isosteres.

    专利号:CN-115515998-A
    优先权日:2020-05-06
    标题 :Synthesis of Polyurethanes by Chain Growth Copolymerization

    专利号:RU-2057129-C1
    优先权日:1989-05-31
    标题:Method of synthesis of pyranyl-cyanoguanidine derivatives
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    合成参考文献


    摘要:Koutentis, P. A.; Ioannidou, H. A., Science of Synthesis Knowledge Updates, (2010) 1, 268.
    摘要:Silva, V. L. M.; Pinto, D. C. G. A.; Santos, C. M. M.; Rocha, D. H. A., Science of Synthesis Knowledge Updates, (2022) 3, 419.
    摘要:Aitken, R. A., Science of Synthesis Knowledge Updates, (2018) 3, 355.
    摘要:Aggarwal, P.; Bebbington, M. W. P., Science of Synthesis Knowledge Updates, (2012) 2, 438.
    摘要:Braverman, S.; Cherkinsky, M., Science of Synthesis Knowledge Updates, (2014) 3, 288.
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