专利号:US-7678789-B2 优先权日:2005-02-11 标 题 :[1,2,4]-dithiazoli(di)ne derivatives, inducers of gluthathione-S-transferase and NADPH quinone oxido-reductase, for prophylaxis and treatment of adverse conditions associated with cytotoxicity in general and apoptosis in particular 发明人:FEENSTRA ROELOF W; KEIZER HISKIAS G; PRAS-RAVES MARIA L; VAN VLIET BERNARD J; VAN SCHARRENBURG GUSTAAF J M 权利人:SOLVAY PHARM BV 摘要:The present invention relates to 5-imino-5H-[1,2,4]-dithiazol-3-yl-amine and [1,2,4]-dithiazolidine-3,5-diylidene-diamine derivatives as inducers of gluthathione-S-transferase (GST) and NADPH quinone oxidoreductase (NQO), to methods for the preparation of these compounds and to novel intermediates useful for the synthesis of said [1,2,4]-dithiazoli(di)ne derivatives. The invention also relates to the use of a compound disclosed herein for the treatment of adverse conditions associated with cytotoxicity in general and apoptosis in particular. The invention relates to compounds of the general formula (I): n nwhereinn nwherein the symbols have the meanings given in the specification.
专利号:EP-1851209-B1 优先权日:2005-02-11 标题:[1,2,4]-dithiazoli(di)ne derivatives, inducers of gluthathione-s-transferase and nadph quinone oxido-reductase, for prophylaxis and treatment of adverse conditions associated with cytotoxicity in general and apoptosis in particular 发明人:FEENSTRA ROELOF W; KEIZER HISKIAS G; PRAS-RAVES MARIA L; VAN VLIET BERNARD J; VAN SCHARRENBURG GUSTAAF J 权利人:ABBOTT HEALTHCARE PRODUCTS BV 摘要:The present invention relates to 5-imino-5H-[1,2,4]-dithiazol-3-yl-amine and [1,2,4]- dithiazolidine-3,5-diylidene-diamine derivatives as inducers of glutha-thione-S- transferase (GST) and NADPH quinone oxidoreductase (NQO), to methods for the preparation of these compounds and to novel intermediates useful for the synthesis of said [1,2,4]-dithiazoli(di)ne derivatives. The invention also relates to the use of a compound disclosed herein for the manufacture of a medicament useful in the for prophylaxis and treatment of adverse conditions associated with cytotoxicity in general and apoptosis in particular. The invention relates to compounds of the general formula (I): wherein the symbols have the meanings given in the specification.
专利号:US-2024215280-A1 优先权日:2022-10-31 标 题:In situ core/shell perovskite nanocrystal material, method of preparation thereof, and light emitting device comprising the same 发明人:LEE TAE-WOO; KIM JOO SUNG 权利人:SEOUL NAT UNIV R&DB FOUNDATION; PEROLED CO LTD 摘要:The present inventive concept relates to an in situ core/shell perovskite nanocrystal film formed by an in situ nanocrystal synthesis process, a method for producing the same, and a light emitting device comprising the same as a light-emitting layer. The in situ core/shell perovskite nanocrystal film formed by the in situ nanocrystal synthesis process according to the present inventive concept exhibits a strong charge confinement effect by nanocrystal formation, and can simultaneously greatly improve the luminescence efficiency and lifetime by maintaining the fast charge transport capability of polycrystalline perovskite.
专利号:US-7875707-B2 优先权日:2002-05-03 标 题:Disaccharides for drug discovery 发明人:MEUTERMANS WIM; WEST MICHAEL; ADAMSON GEORGE; THANH LE GIANG; DRINNAN NICHOLAS B; ABBENANTE GIOVANNI; BECKER BERND; GRATHWOHL MATTHIAS; RAJARATNAM PREMRAJ; TOMETZKI GERALD 权利人:ALCHEMIA LTD 摘要:Methods are described for the preparation of combinatorial libraries of potentially biologically active disaccharide compounds. These compounds are variously functionalized, with a view to varying lipid solubility size, function an other properties, with the particular aim of discovering novel drug or drug-like compounds, or compounds with useful properties. The invention provides intermediates, processes and synthetic strategies for the solution or solid phase synthesis of disaccharides, variously functionalized about the sugar ring, including the addition of aromaticity and charge, and the placement of pharmaceutically useful groups and isosteres.
专利号:CN-115515998-A 优先权日:2020-05-06 标题 :Synthesis of Polyurethanes by Chain Growth Copolymerization
专利号:RU-2057129-C1 优先权日:1989-05-31 标题:Method of synthesis of pyranyl-cyanoguanidine derivatives
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