合成目标产物 D-Phenylalanine Methyl Ester Hydrochloride 主要起始原料 D-Phenylalanine And Acetyl Chloride
(文献来源)合成步骤主要原料 D-Phenylalanine 和 Acetyl Chloride
D-苯丙氨酸置于氯化亚砜体系中,用 甲醇 用作溶剂,以31.2 G (97%)的收率获得d-苯丙氨酸甲酯盐酸盐 参考文献:Heterocyclic Derivatives And Their Use As Antithrombotic Agents 标题:Heterocyclic Derivatives And Their Use As Antithrombotic Agents 摘要:本发明涉及抗血栓化合物,包括q基团,其中q具有化学式(I),其中亚结构(I)是从(A,B和c)中选定的结构,其中x为o或s;X'独立地为ch或n;M为0,1,2或3;其中基团q通过氧原子或可选择取代的氮或碳原子结合,或其药学上可接受的盐或前药.本发明的化合物具有治疗活性,特别是抗血栓作用剂.
专利号:US-7723539-B2 优先权日:2004-06-16 标题:Catalysts based on metal complexes for the synthesis of optically active chrysanthemic acid 发明人:CARLONI SILVIA; BORZATTA VALERIO; MORONI LENI; TANZI GIADA; SARTORI GIOVANNI; MAGGI RAIMONDO 权利人:ENDURA SPA 摘要:Catalysts are described based on metal complexes derived from optically active s compounds, chosen from the classes consisting of bisoxazolines and salicylaldimines supported on an organic or inorganic matrix and employed in particular for the synthesis of optically active chrysanthemic acid.
专利号:US-5002871-A 优先权日:1986-08-18 标 题:Enzymatic membrane method for the synthesis and separation of peptides 发明人:IACOBUCCI GUILLERMO A 权利人:COCA COLA CO 摘要:The present invention provides a membrane method for the enzymatic synthesis of peptides accomplished by shifting the chemical equilibrium that exists in a reaction mixture between charged or ionized reacting amino acids and uncharged or non-ionized peptide product in the presence of a proteolytic enzyme such as thermolysin. The equilibrium is shifted by diffusion of the unchanged peptide product across an ion-rejection membrane which removes the uncharged peptide from the reaction mixture and preferably the diffused uncharged peptide is quickly converted to a charged species that cannot back-diffuse into the reaction mixture so that the uncharged peptide is effectively 'pulled' across the membrane. An enzymatic conversion of the uncharged species utilizing an esterase having proteolytic activity such as aminoacylase I is disclosed. Copermeating reactants can be separated from the product mixture and returned to the reaction mixture. Also, the ion-rejection membrane can be utilized to resolve enantiomers of racemic carboxylic acids including D,L-amino acids.
专利号:US-10266503-B1 优先权日:2016-05-24 标 题 :Sulfoxide ligand metal catalyzed oxidation of olefins 发明人:WHITE M CHRISTINA; AMMANN STEPHEN E; LIU WEI; MA RULIN 权利人:UNIV ILLINOIS 摘要:The enantioselective synthesis of isochroman motifs has been accomplished via Pd(II)-catalyzed allylic C—H oxidation from terminal olefin precursors. Critical to the success of this goal was the development and utilization of a novel chiral aryl sulfoxide-oxazoline (ArSOX) ligand. The allylic C—H oxidation reaction proceeds with the broadest scope and highest levels asymmetric induction reported to date (avg. 92% ee, 13 examples ≥90% ee). Additionally, C(sp 3 )-N fragment coupling reaction between abundant terminal olefins and N-triflyl protected aliphatic and aromatic amines via Pd(II)/sulfoxide (SOX) catalyzed intermolecular allylic C—H amination is disclosed. A range of 52 allylic amines are furnished in good yields (avg. 76%) and excellent regio- and stereoselectivity (avg. >20:1 linear:branched, >20:1 E:Z). For the first time, a variety of singly activated aromatic and aliphatic nitrogen nucleophiles, including ones with stereochemical elements, can be used in fragment coupling stiochiometries for intermolecular C—H amination reactions.
专利号:US-2008021237-A1 优先权日:2004-06-16 标题:Catalysts Based on Metal Complexes for the Synthesis of Optically Active Chrysanthemic Acid
专利号:WO-2005123254-A1 优先权日:2004-06-16 标 题:Catalysts based on metal complexes for the synthesis of optically active chrysanthemic acid
专利号:CN-112979485-A 优先权日:2021-03-25 标题:Application of Type 3A Molecular Sieve in the Synthesis of N-(4-Acetylphenylcarbonyl) Amino Acid Ester
参考标题:Synthesis Of Combretastatin A-4 And 3′-Aminocombretastatin A-4 Derivatives With Aminoacid Containing Pendants And Study Of Their Interaction With Tubulin And As Downregulators Of The Vegf, Htert And C-Myc Gene Expression 作者:Raül Agut,Eva Falomir,Juan Murga,Celia Martín-Beltrán,Raquel Gil-Edo,Alberto Pla,Miguel Carda,J. Alberto Marco 摘要:Natural Product Combretastatin A-4 (Ca-4) And Its Nitrogenated Analogue 3′-Aminocombretastatin A-4 (Amca-4) Have Shown Promising Antitumor Activities. In This Study, A Range Of Ca-4 And Amca-4 Derivatives Containing Amino Acid Pendants Have Been Synthesized In Order To Compare Their Biological Actions With Those Of Their Parent Compounds. Thus, Inhibition Of Cell Proliferation On Tumor Cell Lines Ht-29
合成参考文献
摘要:Arimitsu, S.; Cahard, D., Science of Synthesis: Modern Strategies in Organofluorine Chemistry , (2024) 1, 15.