CAS: 11121-48-5; (3-Oxo-6-Oxido-2,4,5,7-Tetraiodo-3H-Xanthen-9-yl)-3,4,5,6-Tetrachlorobenzoate Sodium Salt

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ParaquatParaquat NAD

四氯荧光素置于碘,碘酸体系中,用 乙醇,水 用作溶剂,以43%的收率获得食用色素红色105号
参考文献:Rose Bengal Analogs And Vesicular Glutamate Transporters (Vgluts)
标题:Rose Bengal Analogs And Vesicular Glutamate Transporters (Vgluts)
摘要:Vesicular Glutamate Transporters (Vgluts) Allow The Loading Of Presynaptic Glutamate Vesicles And Thus Play A Critical Role In Glutamatergic Synaptic Transmission. Rose Bengal (Rb) Is The Most Potent Known Vglut Inhibitor (K-I 25 Nm); Therefore We Designed,Synthesized And Tested In Brain Preparations,A Series Of Analogs Based On This Scaffold. We Showed That Among The Two Tautomers Of Rb,The Carboxylic And Not The Lactonic Form Is Active Against Vgluts And Generated A Pharmacophore Model To Determine The Minimal Structure Requirements. We Also Tested Rb Specificity In Other Neurotransmitter Uptake Systems. Rb Proved To Potently Inhibit Vmat (K-I 64 Nm) But Weakly Vacht (K-I > 9.7 Mu M) And May Be A Useful Tool In Glutamate/acetylcholine Co-Transmission Studies. (C) 2010 Elsevier Ltd. All Rights Reserved.
Doi:10.1016/j.Bmc.2010.06.069

专利信息

专利号:US-11535703-B2
优先权日:2017-01-10
标 题:Methanesulfonic acid mediated solvent free synthesis of conjugated porous polymer networks
发明人：FANG LEI; Guo zi-hao; WANG CHENXU; ZHANG QIANG; ZHOU HONG-CAI
权利人:TEXAS A & M UNIV SYS
摘要:The present disclosure relates to synthesis of porous polymer networks and applications of such materials. The present disclosure relates to a method of fabricating of a porous polymer network comprising: (a) providing: (i) a first reactant comprising a plurality of compounds comprising at least one acetyl group, said plurality of compounds comprising at least one compound type, and (ii) a second reactant comprising an alkylsulfonic acid, and (b) creating a solution of said reactants, (c) casting said solution in a form, and (d) treating said solution under such conditions so as to produce a porous polymer network. In one embodiment, the invention relates to a porous polymer network which has a basic structure selected from the group consisting of

专利号:US-9731284-B1
优先权日:2014-03-24
标 题:Process for oxidation of amines in the synthesis of energetic materials
发明人：SANCHEZ PEGGY A; GRISWOLD KIMBERLY; GORUN SERGIU M; PATEL HEMANTBHAI H
权利人:US ARMY; SETON HALL UNIV
摘要:A process for use of composite catalysts for oxidation of amines during synthesis of energetic compounds. This method overcomes the safety concerns associated with dangerous reaction conditions for these energetic materials. The process requires exposing phthalocyanine conjugated to an inorganic substrate to the precursor reactant and activating the composite material to light and oxygen to covert amine groups into oxidized nitrogen species.

专利号:US-4190579-A
优先权日:1977-12-29
标题:Synthesis of beta-lactams from azetidine carboxylic acid esters
发明人：LIPSHUTZ BRUCE H; WASSERMAN HARRY H; WU JAMES S
权利人:RESEARCH CORP
摘要:Azetidine carboxylic acid esters are converted into enol silyl ethers which, as enamino ketene acetals, undergo ready oxidative cleavage of the ethylenically unsaturated double bond, e.g. by dye-sensitized photo-oxygenation, to form beta-lactams. The beta-lactams and substitution products thereof are useful intermediates in the synthesis of biologically active lactams.

专利号:US-6417380-B1
优先权日:1987-12-31
标 题 :Synthesis of 1,2-dioxetanes and intermediates therefor
发明人：BRONSTEIN IRENA Y; EDWARDS BROOKS
摘要:Compounds having the formula: n wherein T is a polycycloalkylidene group (e.g., adamant-2-ylidene); R is a C 1-20 alkyl, aralkyl or cycloalkyl group; and Y is a fluorescent chromophore (e.g., n m-phenylene), produced by reacting a compound having the formula: n with an R-ylating agent (e.g., R 2 SO 4 ) in the presence of an alkali metal alkoxide in a polar aprotic solvent. Also, compounds having the formula: n are produced by reacting a compound having the formula: n with n wherein X is an electronegative leaving group (e.g., a halogen anion such as chloride ion) in the presence of a Lewis base (e.g., a trialkyl-amine) dissolved in an aprotic organic solvent (e.g., benzene or toluene). Also, compounds having the formula n are produced by reacting a compound of the formula n with a tetra-O-acylated-O-hexopyranoside halide, then hydrolyzing off the protective acyl groups. The aforementioned compounds and procedures are useful in the synthesis of enzyme-cleavable 1,2-dioxetane ring systems that can serve as members of a binding pair employed, for example, in chemiluminescent immunoassays, DNA probe assays, and direct assays for an enzyme.

专利号:US-5763681-A
优先权日:1989-09-06
标 题 :Synthesis of stable, water-soluble chemiluminescent 1,2-dioxetanes and intermediates therefor
发明人：EDWARDS BROOKS; JUO RHOU-RONG
权利人:TROPIX INC
摘要:A novel synthesis of compound having the formula: ##STR1## wherein T is a stabilizing spiro-linked polycycloalkylidene group, R 3 is a C 1 -C 20 alkyl, aralkyl or heteroatom containing group, Y is an aromatic fluorescent chromophore, and Z is a cleavable group which, when cleaved, induces decomposition of the dioxetane ring and emission of optically detectable light, is disclosed. A tertiary phosphorous acid alkyl ester of the formula: n n (R.sup.1 O).sub.3 P n n wherein R 1 is a lower alkyl group, is reacted with an aryl dialkyl acetal produced by reacting a corresponding aryl aldehyde with an alcohol of the formula: n n R.sup.3 OH n n wherein R 3 is as defined above, to produce a 1-alkoxy-1-aryl-methane phosphonate ester of the formula: ##STR2## reacting the phosphonate with base to produce a phosphonate-stabilized carbanion, reacting the carbanion with a ketone of the formula: ##STR3## wherein T is as defined above, to produce an enol ether of the formula: ##STR4## then oxygenating the double bond in the enol ether to give the corresponding 1,2-dioxetane compound.

专利号:US-2025171493-A1
优先权日:2022-03-05
标题 :Processes for synthesis of withanolides and withaferins and analogs thereof
发明人：LOPCHUK JUSTIN MATTHEW
权利人:H LEE MOFFITT CANCER CT & RES
摘要:The present disclosure provides processes for the synthesis of withanolides such as Withanolide A and Withanolide D.