CAS: 106-47-8; 4-Chloroaniline

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CAS号106-39-8 对氯溴苯 | CAS号100-00-5 对硝基氯苯 | CAS号1679-18-1 4-氯苯硼酸 | CAS号106-40-1 对溴苯胺 | CAS号1602-00-2 4,4'-二氯偶氮苯 | CAS号3296-05-7 1-叠氮-4-氯苯 溶液 | CAS号637-87-6 对氯碘苯 | CAS号24889-00-7 2-(4-chlorophen... | CAS号932-98-9 1-chloro-4-nitr... | CAS号18437-66-6 4-氯-(N-B°C)苯胺 | CAS号105891-83-6 6-(4-chloroanil... | CAS号112182-50-0 6-chloro-2-phen... | CAS号110605-11-3 2-chloro-N-(4-c... | CAS号105949-65-3 (4-chlorophenyl... | CAS号1065275-50-4 1-(4-氯苯基)-7,7-二... | CAS号111870-31-6 5-chloro-N-(4-c... | CAS号110605-09-9 N-(4-chlorophen... | CAS号110605-10-2 N-(4-chlorophen... | CAS号105192-41-4 (2-氨基-5-氯苯基)-3-吡啶甲酮 | CAS号105207-76-9 2-(4-chlorophen...

4-溴苯胺置于copper(I) Oxide,四甲基氯化铵,L-脯氨酸体系中,用 乙醇 用作溶剂,化学反应 15.0H,以94%的收率获得对氯苯胺
参考文献:Copper-Catalyzed Conversion Of Aryl And Heteroaryl Bromides Into The Corresponding Chlorides
标题:Copper-Catalyzed Conversion Of Aryl And Heteroaryl Bromides Into The Corresponding Chlorides
摘要:描述了一种合成芳基和杂芳基氯化物的高效方法.在温和反应条件下,芳基和杂芳基溴化物与四甲基氨基氯化铵在铜催化剂存在下顺利反应,产生了相应的氯化物,产率令人满意至非常好.
Doi:10.1039/c2Cc34944B

专利信息

专利号:WO-2018019249-A1
优先权日:2016-07-27
标题 :Process for continuous flow synthesis of 4-chlorophenylhydrazine salt
发明人：MA BING; PAN SHUAI; PU DENGPAN
权利人:SHANGHAI HYBRID-CHEM TECH
摘要:The present invention provides a process for continuous flow synthesis of a 4-chlorophenylhydrazine salt; the three reaction steps of diazotization, reduction, and acidolysis salt formation are organically integrated in an innovative manner; using a 4-chloroaniline acidic stock solution, a diazotization reagent, a reducing agent, and acid as starting materials, continuously performing in sequence the three reaction steps of diazotization, reduction, and acidolysis salt formation to obtain a 4-chlorophenylhydrazine salt; the synthesis process is carried out in an integrated reactor and is an integrated solution. The reaction starting materials are added continuously via the material feed inlet of the integrated reactor; the three reaction steps of diazotization, reduction, and acidolysis salt formation are performed continuously in sequence in the integrated reactor; 4-chlorophenylhydrazine salt is obtained continuously from the material outlet of the integrated reactor; the total reaction time is ≤20 minutes. In comparison with conventional production processes, the total reaction time is greatly shortened and safety is significantly improved; furthermore, neither the reaction process nor the reaction product contain any reaction by-products (such as diazoamino compounds and reduction reaction intermediates); the described continuous flow process does not require an additional purification step and produces a high-purity product having a purity of 99% or higher, while also achieving a maximum yield of 99.5% or higher.

专利号:WO-2025134140-A1
优先权日:2023-12-19
标题:A method for the synthesis of substituted anthranilic amide compounds, intermediates and salts thereof
发明人：MALVIYA NITIN JAIKANT; SINGH VIPENDER; SHAH JIGARKUMAR HARKISHANDAS; KALE MANOJ GANPAT; KAVITAKE SANTOSH GIRIDHAR; BORHADE AJIT SAHEBRAO; KLAUSENER ALEXANDER G M
权利人:PI INDUSTRIES LTD
摘要:The present invention discloses a method for the synthesis of compounds of formula (I) or a salt thereof, wherein, R is selected from hydrogen, halogen, cyano, C1-C12 alkyl, C1-C12 haloalkyl, C1-C12 alkoxy, C1-C12 haloalkoxy, or C3-C8 cycloalkyl; R4 is selected from hydrogen, C1-C12 alkyl, C2-C12 alkenyl, C2-C12 alkynyl, C1-C12 haloalkyl, C2-C12 haloalkenyl, C2-C12 haloalkynyl, C1-C12 alkoxy, C1-C12 haloalkoxy, C3-C8 cycloalkyl, or C3-C8 cycloalkyl-C1-C10 alkyl; and n represents an integer selected from 0-4. The method further comprises the synthesis of an anthranilic diamide compound of formula (A).

专利号:US-2023339906-A1
优先权日:2020-09-26
标 题 :A process for the synthesis of anthranilic acid/amide compounds and intermediates thereof
发明人：SYTHANA SURESH KUMAR; NAGLE PRAMOD; KUMAR VIJAY KUMAR; KANAWADE SHRIKANT BHAUSAHEB; CHANDRE TUKARAM NIVRUTTI; THUBE VINAYAK KISAN; PATIL PRADEEP PRAKASH; SHUKLA SHALINI; SHENDE KANTILAL BALU; PATRA PRANAB KUMAR; KLAUSENER ALEXANDER G M
权利人:PI INDUSTRIES LTD; PI INDUSTRIES LTD
摘要:The present invention discloses a process for the synthesis of compound of formula (VII) or a salt thereof,wherein, R, R1, R2, R3, R4a and R4b are as defined in the detailed description. The process further comprises the synthesis of an anthranilic diamide compound of formula (I).

专利号:WO-2015198349-A1
优先权日:2014-06-25
标 题 :A one pot synthesis of 3-substituted quinoline carboxylates and its derivatives
发明人：GADAKH SUNITA KHANDERAO; SUDALAI ARUMUGAM
权利人:COUNCIL SCIENT IND RES
摘要:The present invention provides a one pot, simple, cost effective and industrially feasible catalytic synthesis of quinolines or substituted quinolines from anilines with yield >80% yield. The present invention also discloses a process for the synthesis of oxolinic acid using quinolines with yield > 45%.

专利号:US-6028237-A
优先权日:1996-12-16
标题:Synthesis of cyclopropylacetylene
发明人：PARSONS JR RODNEY LAWRENCE
权利人:DU PONT PHARM CO
摘要:The present invention relates generally to novel methods for the synthesis of cyclopropylacetylene which is a reagent in the asymmetric synthesis of (S)-6-chloro-4-cyclopropylethynyl-4-trifluoromethyl-1,4-dihydro-2H-3,1-benzoxazin-2-one which is a useful human immunodeficiency virus (HIV) reverse transcriptase inhibitor.

专利号:WO-2017089470-A1
优先权日:2015-11-27
标 题:Process for the synthesis of aryldiazonium salts using nitrogen oxides in oxygen-containing gas streams, especially from industrial waste gases
发明人：HOFMANN DAGMAR; HOFMANN JOSEFA; HEINRICH MARKUS
权利人:Friedrich-Alexander-Universität Erlangen-Nürnberg
摘要:The present invention relates to a process for the synthesis of aryldiazonium salts using nitrogen oxides in oxygen-containing gas streams, especially from industrial waste gases.