CAS: 104901-43-1; Methyl 3-Bromo-4-Methylbenzoate

相似化合物

7697-26-9 36276-24-1 68120-35-4

上下游产品

4-methyl-benzoic acid methyl ester methanol 3-bromo-4-methylbenzoic acid dimethyl sulfate2-(3-bromo-4-bromomethylbenzyloxy)tetrahydropyran 3-bromo-4-(bromomethyl)benzoic acid methyl ester [3-bromo-4-(bromomethyl)phenyl]methanol methyl 4-methyl-3-methoxybenzoate

对甲基苯甲酸甲酯置于三氯化铝,溴体系中,用46%的收率获得3-溴-4-甲基苯甲酸甲酯
参考文献:(C5Me5)Rh(Pme3)(R)H中烷烃和芳烃碳氢键活化的机理和热力学
标题:(C5Me5)Rh(Pme3)(R)H中烷烃和芳烃碳氢键活化的机理和热力学
摘要:使用整体激活参数反应生成C 6/h 6/ 和 (C 5/me 5/)Rh(Pme 3/)(C 6/d 5/)D Delta H +/-30.5 +/-0.8 Kcal/mol 和 ..Delta..S +/-14.9+/-2.5 Eu.烷基和芳基氢化物复合物也可以通过在烷烃存在下从 (C 5/me 5/)Rh(Pme 3/)H 2/ 光化学挤出 H 2/ 产生或芳烃溶剂.在竞争实验中,苯对环戊烷的选择性为 5.4:1,在-35 0/c 时表现出.在-45 0/c 的甲苯溶剂中辐照产生的产物中,观测到甲苯的所有可能 Ch 键的活化增加了 57% » 间位,36% 对位,7% 邻位和 <1% 苄基.苯和甲苯,间二甲苯,邻二甲苯或对二甲苯的活化之间的热力学控制竞争显示出对苯的偏好为
Doi:10.1021/ja00318A018

专利信息

专利号:US-2024400552-A1
优先权日:2016-11-11
标题 :Heterocyclic modulators of lipid synthesis
发明人：BUCKLEY DOUGLAS I; DUKE GREGORY; WAGMAN ALLAN S; EVANCHIK MARC; MCDOWELL ROBERT S
权利人:SAGIMET BIOSCIENCES INC
摘要:Compounds that are fatty acid synthesis modulators are provided. The compounds may be used to treat disorders characterized by dysregulation of the fatty acid synthase function by modulating the function and/or the fatty acid synthase pathway. Methods are provided for treating such disorders including viral infections, such as hepatitis C infection, cancer and metabolic disorders, such as non-alcoholic steatohepatitis (NASH).

专利号:US-11622968-B2
优先权日:2011-03-08
标 题:Heterocyclic modulators of lipid synthesis
发明人：BUCKLEY DOUGLAS; DUKE GREGORY; WAGMAN ALLAN S; EVANCHIK MARC; MCDOWELL ROBERT S
权利人:SAGIMET BIOSCIENCES INC
摘要:Compounds that are fatty acid synthesis modulators are provided. The compounds may be used to treat disorders characterized by disregulation of the fatty acid synthase function by modulating the function and/or the fatty acid synthase pathway. Methods are provided for treating such disorders including viral infections, such as hepatitis C infection, cancer and metabolic disorders, such as non-alcoholic steatohepatitis (NASH).

专利号:US-11034690-B2
优先权日:2016-11-11
标 题:Heterocyclic modulators of lipid synthesis
发明人：BUCKLEY DOUGLAS I; DUKE GREGORY; WAGMAN ALLAN S; EVANCHIK MARC; MCDOWELL ROBERT S
权利人:SAGIMET BIOSCIENCES INC; SAGINIET BIOSCIENCES INC
摘要:Compounds that are fatty acid synthesis modulators are provided. The compounds may be used to treat disorders characterized by disregulation of the fatty acid synthase function by modulating the function and/or the fatty acid synthase pathway. Methods are provided for treating such disorders including viral infections, such as hepatitis C infection, cancer and metabolic disorders, such as non-alcoholic steatohepatitis (NASH).

专利号:US-9809591-B2
优先权日:2011-03-08
标题 :Heterocyclic modulators of lipid synthesis
发明人：OSLOB JOHAN D; MCDOWELL ROBERT S; JOHNSON RUSSELL; YANG HANBIAO; EVANCHIK MARC; ZAHARIA CRISTIANA A; CAI HAIYING; HU LILY W
权利人:3-V BIOSCIENCES INC
摘要:Compounds that are fatty acid synthesis modulators are provided. The compounds may be used to treat disorders characterized by disregulation of the fatty acid synthase function by modulating the function and/or the fatty acid synthase pathway. Methods are provided for treating such disorders including viral infections, such as hepatitis C infection, cancer and metabolic disorders.

专利号:US-12227528-B2
优先权日:2017-11-09
标 题:Glucose-sensitive albumin-binding derivatives
发明人：KRUSE THOMAS; KOFOD-HANSEN MIKAEL; MUENZEL MARTIN WERNER BORCHSENIUS; THOEGERSEN HENNING; SAUERBERG PER; EWALD JAKOB; BEHRENS CARSTEN; HOEG-JENSEN THOMAS; BALSANEK VOJTECH; DROBNAKOVA ZUZANA; DROZ LADISLAV; HAVRANEK MIROSLAV; KOTEK VLADISLAV; STENGL MILAN; SNAJDR IVAN; DRUSANOVA HANA
权利人:NOVO NORDISK AS
摘要:This invention relates to glucose-sensitive albumin-binding diboron conjugates. More particularly the invention provides novel diboron compounds, and in particular diboronate or diboroxole compounds, useful as intermediate compounds for the synthesis of diboron conjugates.

专利号:US-2019308969-A1
优先权日:2016-11-11
标 题 :Heterocyclic modulators of lipid synthesis