CAS: 968-21-8; Leucyltyrosine

该化合物是一种由氨酸液和铁合金组成的二极酸,通过浸渍物联结连接起来,该化合物具有生物化学和制药研究的兴趣,因为它是研究酶动能学,特别是小虫和蛋白质化验的基底,其稳定的peptide结构使它适合于调查代谢途径和蛋白相互作用.L-L-L-tyrosine还用于浸渍物合成和分析应用中的参考标准,其特点是高纯度和一贯质量,确保实验环境中的可靠性能.其明确界定的特性有利于科学研究取得准确和可复制的结果.

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上下游产品

N-((Ξ)-2-bromo-4-methyl-valeryl)-L-tyrosineN-((Ξ)-2-bromo-4-methyl-valeryl)-L-tyrosine N-(N-benzyloxycarbonyl-L-leucyl)-L-tyrosine benzyl esterN-(N-benzyloxycarbonyl-L-leucyl)-L-tyrosine benzyl ester L-tyrosine ethyl ester N-((Ξ)-2-bromo-4-methyl-valeryl)-L-tyrosine ethyl esterN-((Ξ)-2-bromo-4-methyl-valeryl)-L-tyrosine ethyl ester3-(4-hydroxybenzyl)-6-isobutylpiperazine-2,5-dione Z-Ile-Leu-Tyr-OH L-thyroxine B°C-Gly-Ser-Lys(Z)-Val-Ile-Tyr-OH

合成工艺路线路线简述

  • 92954-90-0 + 35661-60-0 = 968-21-8
    反应条件:1.1 Reagents: Diisopropylethylamine Solvents: Methanol,Dimethylformamide; 0.5 H,Rt1.2 Reagents: Piperidine1.3 Reagents: Diisopropylethylamine,1-[bis(Dimethylamino)Methylene]-1H-Benzotriazolium Hexafluorophosphate(1-) 3-Oxi...; 0.5 H,Rt1.4 Reagents: Trifluoroacetic Acid; 2 H,Rt
    标题:Preparation Of Oligopeptides And Pharmaceutical Application Thereof
    参考文献:China]

    = 968-21-8 [标题:Reaction Conditions
    标题:Modeling The Qsar Of Ace Inhibitory Peptides Based On Mlr
    作者:Liu,Jing; Peng,Jian-Qiu; Guan,Xiao
    参考文献:Fenxi Kexue Xuebao 日期:2012 卷标:28(1) 页码:16-22]

    = 968-21-8 [标题:Reaction Conditions
    标题:Preparation Of Dipeptide Ss Derived From Silkworm Chrysalis Protein Source As Angiotensin Converting Enzyme Inhibitor For Treatment Of Hypertension
    参考文献:China]

    = 968-21-8 [标题:Reaction Conditions
    标题:On The Use Of An O-Cyclohexyl Ether For Protection Of Tyrosine In Peptide Synthesis
    作者:Giralt,E.; Andreu,D.; Eritja,R.; Grandas,A.; Pedroso,E.
    参考文献:Anales De Quimica 日期:1983 卷标:79(3) 页码:390-1]

    = 968-21-8 [标题:Reaction Conditions
    标题:A Method Of Peptide Bond Formation
    作者:Yamashita,S.; Ishikawa,N.
    参考文献:Experientia 日期:1968 卷标:24(10) 页码:1079-80]

    92954-90-0 + 35661-60-0 = 968-21-8
    反应条件:1.1 Reagents: Dimethylformamide Solvents: Dimethylformamide,Dichloromethane; 60 Min,Rt1.2 Reagents: Piperidine1.3 Reagents: Diisopropylethylamine,1-[bis(Dimethylamino)Methylene]-1H-Benzotriazolium Hexafluorophosphate(1-) 3-Oxi...; 0.5 H,Rt1.4 Reagents: Trifluoroacetic Acid; 2 H,Rt
    标题:Preparation Of Oligopeptide Cd07 And Pharmaceutical Application Thereof
    参考文献:China]

    = 968-21-8 [标题:Reaction Conditions
    标题:Identification Of Antihyperuricemic Peptides In The Proteolytic Digest Of Shark Cartilage Water Extract Using In Vivo Activity-Guided Fractionation
    作者:Murota,Itsuki; Taguchi,Satoko; Sato,Nobuyuki; Park,Eun Young; Nakamura,Yasushi; Et Al
    参考文献:Journal Of Agricultural And Food Chemistry 日期:2014 卷标:62(11) 页码:2392-2397]

    = 968-21-8 [标题:Reaction Conditions
    标题:Green Coffee Bean Protein-Derived Tripeptide And Dipeptide And Hypotriglyceridemics Containing Them
    参考文献:Japan]

    = 968-21-8 [标题:Reaction Conditions
    标题:Preparation Of Peptide Angiotensin Converting Enzyme Inhibitors
    参考文献:European Patent Organization]

    = 968-21-8 [标题:Reaction Conditions
    标题:Resolution Of Amino Acids. Xii. Preparation Of L-2-Amino-5-Arylpentanoic Acids,Constituent Amino Acids In Am Toxins
    作者:Shimohigashi,Yasuyuki; Lee,Sannamu; Izumiya,Nobuo
    参考文献:Bulletin Of The Chemical Society Of Japan 日期:1976 卷标:49(11) 页码:3280-4
📜O-Benzyl-N-(N-Benzyloxycarbonyl-L-Leucyl)-L-Tyrosine置于1,4-二氧六环,钯,溶剂黄146体系中,化学反应生成 L-亮氨酰-L-酪氨酸
参考文献:Wuensch Et Al.,Chemische Berichte,1958,Vol. 91,P. 542,546
标题:Wuensch Et Al.,Chemische Berichte,1958,Vol. 91,P. 542,546

海关参考信息

专利信息


专利号:WO-9840489-A1
优先权日:1997-03-10
标 题 :Antisense base sequences
发明人：MARUTA YOSHIYUKI; SAITO HIDEAKI
权利人:JAPAN TOBACCO INC; MARUTA YOSHIYUKI; SAITO HIDEAKI
摘要:A novel technique for enhancing, in the techniques for inhibiting the synthesis of proteins, the inhibitory effects with the use of antisense base sequences. Specifically, antisense base sequences containing two or more sequences of desired structural genes or parts of the same consecutively linked in the antisense direction; expression vectors having the above antisense base sequences; products of transformation by the above expression vectors; and a method for inhibiting the expression of proteins by using the above antisense base sequences.

专利号:WO-2009056901-A1
优先权日:2007-10-31
标题:Cyclodipeptide synthases (cdss) and their use in the synthesis of linear dipeptides

专利号:WO-2013067523-A1
优先权日:2011-11-04
标题 :A prokaryote-based cell-free system for the synthesis of glycoproteins

专利号:FR-2985259-A1
优先权日:2012-01-03
标 题 :C-ALPHA-AMIDE PEPTIDES, PROCESSES FOR THEIR PREPARATION AND THEIR USES AS PRECURSORS OF C-ALPHA-THIOESTER PEPTIDES FOR THE SYNTHESIS OF PROTEINS

专利号:AU-726807-B2
优先权日:1997-04-11
标 题:Methods and compositions for synthesis of long chain polyunsaturated fatty acids

专利号:SG-191214-A1
优先权日:2010-12-17
标题:Synthetic pathway generating apparatus, synthesis pathway generating method, synthesis pathway generating program, and method of producing 3-hydroxypropionic acid, crotonyl alcohol and butadiene

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主要参考文献


1: Domingues P, Fonseca C, Reis A, Domingues MR. Identification of isomeric spin adducts of Leu-Tyr and Tyr-Leu free radicals using liquid chromatography-tandem mass spectrometry. Biomed Chromatogr. 2012 Jan;26(1):51-60. doi: 10.1002/bmc.1624. Epub 2011 Mar 23. doi: 10.1016/j.jmr.2011.06.021. Epub 2011 Jul 1.
4: Rajendran VM, Berteloot A, Ishikawa Y, Khan AH, Ramaswamy K. Transport of carnosine by mouse intestinal brush-border membrane vesicles. Biochim Biophys Acta. 1984 Dec 19;778(3):443-8. Epub 2006 Apr 21. doi: 10.1007/BF00552654.
10: Krause JA, Baures PW, Eggleston DS. Molecular structures of L-Leu-L-Tyr, Gly-D,L-Met.p-toluenesulfonate and L-His-L-Leu. Acta Crystallogr B. 1993 Feb 1;49 ( Pt 1):123-30. doi: 10.1002/jms.1543. Russian. Russian.

合成参考文献


摘要:T. Wieland and H. Bende. Chem. Ber. 98, 504 (1965).
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